論文

査読有り
2008年4月

Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system

JOURNAL OF PHARMACOLOGICAL SCIENCES
  • Shigekazu Watanabe
  • ,
  • Jun Yamakami
  • ,
  • Masao Tsuchiya
  • ,
  • Tomoko Terajima
  • ,
  • Junko Kizu
  • ,
  • Seiji Hori

106
4
開始ページ
566
終了ページ
570
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1254/jphs.FP0071816
出版者・発行元
JAPANESE PHARMACOLOGICAL SOC

Although theophylline has been suggested to have an anti-inflammatory effect, there have been few reports to show the in vivo effect and the mechanism of anti-inflammatory activity of theophylline experimentally. To reveal the anti-inflammatory activity of theophylline, we studied the effect of theophylline and its metabolites on carrageenan-induced edema in rat foot pad. Subcutaneous injection of theophylline (5-100 mg/kg) inhibited carrageenan-induced edema dose-dependently. Theophylline metabolites, that is, 1-methylxanthine, 3-methylxanthine, I-methyluric acid, and 1,3-dimethyluric acid (equimolar dose to 50 mg/kg of theophylline), did not inhibit the edema significantly. The inhibitory effect of theophylline on carrageenan-induced edema disappeared by pretreatment with aminoglutethimide, an inhibitor of glucocorticoid synthesis and with mefepristone, an antagonist of the glucocorticoid receptor. These results suggest that theophylline itself has anti-inflammatory activity and the glucocorticoid-glucocorticoid receptor system is involved in the anti-inflammatory activity of theophylline.

リンク情報
DOI
https://doi.org/10.1254/jphs.FP0071816
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18391482
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000255308300008&DestApp=WOS_CPL
ID情報
  • DOI : 10.1254/jphs.FP0071816
  • ISSN : 1347-8613
  • PubMed ID : 18391482
  • Web of Science ID : WOS:000255308300008

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