2016年5月
Event- and time-dependent decline of outcome information in the primate prefrontal cortex
SCIENTIFIC REPORTS
- ,
- ,
- 巻
- 6
- 号
- 開始ページ
- 25622
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/srep25622
- 出版者・発行元
- NATURE PUBLISHING GROUP
The prefrontal cortex (PF) is involved in outcome-based flexible adaptation in a dynamically changing environment. The outcome signal dissipates gradually over time, but the temporal dynamics of this dissipation remains unknown. To examine this issue, we analyzed the outcome-related activity of PF neurons in 2 monkeys in a distance discrimination task. The initial prestimulus period of this task varied in duration, allowing us to dissociate the effects of time and event on the decline in previous outcome-related activity-previous correct versus previous error. We observed 2 types of decline in previous outcome representation: PF neurons that ceased to encode the previous outcome as time passed (time-dependent) and neurons that maintained their signal but it decreased rapidly after the occurrence of a new external event (event-dependent). Although the time-dependent dynamics explained the decline in a greater proportion of neurons, the event-dependent decline was also observed in a significant population of neurons.
- リンク情報
- ID情報
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- DOI : 10.1038/srep25622
- ISSN : 2045-2322
- PubMed ID : 27162060
- Web of Science ID : WOS:000375446500001