2014年5月
Palladium(0)-Catalyzed Carbon-Hydrogen Bond Functionalization for the Synthesis of Indoloquinazolinones
ADVANCED SYNTHESIS & CATALYSIS
- ,
- ,
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- 巻
- 356
- 号
- 7
- 開始ページ
- 1533
- 終了ページ
- 1538
- 記述言語
- 英語
- 掲載種別
- 研究発表ペーパー・要旨(国際会議)
- DOI
- 10.1002/adsc.201400078
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
The indoloquinazolinone ring system has attracted considerable attention as a pharmacophore, because it shows various biological activities. The reported synthetic methods for the compound are simple and direct, but are not effective for the direct synthesis of indoloquinazolinone with a methylene group at the C-6 position. A palladium(0)-catalyzed cyclization of chloroquinazolinone via CH functionalization was developed for a concise synthesis of indoloquinazolinone derivatives. The presence of a substituent at the C-6 position is important for obtaining the product in good yield. The conformation of the reaction intermediate, in particular the NCPd bond angle, is important for the regioselectivity of the reaction.
- リンク情報
- ID情報
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- DOI : 10.1002/adsc.201400078
- ISSN : 1615-4150
- eISSN : 1615-4169
- Web of Science ID : WOS:000336505000016