2014年2月
Asymmetric Synthesis of (-)-Aurantioclavine via Palladium-Catalyzed Intramolecular Allylic Amination
ORGANIC LETTERS
- ,
- ,
- ,
- 巻
- 16
- 号
- 3
- 開始ページ
- 996
- 終了ページ
- 999
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/ol4037314
- 出版者・発行元
- AMER CHEMICAL SOC
The total synthesis of (-)-aurantioclavine (1) was accomplished based on an intramolecular asymmetric amination of allyl carbonate 3 containing a p-tosylamide group. The reaction using tris(dibenzylideneacetone)dipalladium(0), tBu-phosphinooxazoline, and Bu4NCl in CH2Cl2 gave azepane 2 in 77% yield with 9596 enantiomeric excess. The obtained azepane 2 was also converted to a substructure of communesin F.
- リンク情報
- ID情報
-
- DOI : 10.1021/ol4037314
- ISSN : 1523-7060
- eISSN : 1523-7052
- ORCIDのPut Code : 21836931
- PubMed ID : 24460216
- Web of Science ID : WOS:000331163900090
- ORCIDで取得されたその他外部ID : a:1:{i:0;a:1:{s:8:"other-id";s:19:"WOS:000331163900090";}}