Papers

Peer-reviewed
Jun, 2019

Appropriate echo time selection for quantitative susceptibility mapping.

Radiological physics and technology
  • Yuki Kanazawa
  • ,
  • Yuki Matsumoto
  • ,
  • Masafumi Harada
  • ,
  • Hiroaki Hayashi
  • ,
  • Tsuyoshi Matsuda
  • ,
  • Hideki Otsuka

Volume
12
Number
2
First page
185
Last page
193
Language
English
Publishing type
DOI
10.1007/s12194-019-00513-x

The purpose of our study was to clarify the dependence of quantitative susceptibility mapping (QSM) on echo time (TE). We constructed a phantom consisting of six tubes; three tubes were filled with different concentrations (0.5, 1.0, and 2.5 mM) of gadopentetate dimeglumine (Gd-DTPA), and three were filled with different concentrations (100, 200, and 350 mg/mL) of calcium hydroxyapatite. Real and imaginary images from multi-echo spoiled gradient-echo data (12 echoes) were acquired. We then used four datasets with three serial echoes. The QSM procedure consists of four steps: field map estimation, phase unwrapping, background removal, and dipole inversion. For each sample, we compared the measured mean susceptibility value with the theoretical susceptibility value and conducted a linear regression analysis. Accordingly, the relationship between the measured susceptibility and concentration of Gd-DTPA was shown to agree well with the theoretical values (TEs = 16.4, 20.8, and 25.2 ms; slope = 0.24, R2 = 1.00). Furthermore, the relationship between the measured susceptibility and concentration of hydroxyapatite also showed good linearity (TEs = 16.4, 20.8, and 25.2 ms; slope = - 0.00121, R2 = 1.00). In conclusion, the optimization of the TE in QSM makes it possible to obtain more detailed information regarding the susceptibility of biomaterials.

Link information
DOI
https://doi.org/10.1007/s12194-019-00513-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30980255
ID information
  • DOI : 10.1007/s12194-019-00513-x
  • ISSN : 1865-0333
  • Pubmed ID : 30980255

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