Papers

Peer-reviewed
Feb, 2002

Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor

NMR IN BIOMEDICINE
  • M Harada
  • ,
  • M Uno
  • ,
  • F Hong
  • ,
  • S Hisaoka
  • ,
  • H Nishitani
  • ,
  • T Matsuda

Volume
15
Number
1
First page
69
Last page
74
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1002/nbm.759
Publisher
JOHN WILEY & SONS LTD

The apparent diffusion coefficients (ADCs) of water and brain metabolites were determined by proton MR spectroscopy on a clinical MR scanner for healthy volunteers and for pathological changes in cases of acute cerebral infarction and brain tumor. The ADCs of N-acetyl aspartate (NAA) and creatines in tissue involved in acute infarction were decreased compared to normal control values, while in tumors they showed increased values. Since NAA is a neuronal marker, these findings suggest that neuronal cell viscosity changes according to the pathological status of the tissue. The lactate ADC was significantly larger than the values for other major metabolites in cases of ischemia and tumor, suggesting that lactate is present in a different compartment. These results indicate that metabolite diffusion data can be used to reveal changes in the intracellular environment depending on the pathological status. Copyright (C) 2001 John Wiley Sons, Ltd.

Link information
DOI
https://doi.org/10.1002/nbm.759
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11840555
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000174025700009&DestApp=WOS_CPL
ID information
  • DOI : 10.1002/nbm.759
  • ISSN : 0952-3480
  • Pubmed ID : 11840555
  • Web of Science ID : WOS:000174025700009

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