2020年9月
Epithelial TRPV1 channels: Expression, function, and pathogenicity in the oral cavity
JOURNAL OF ORAL BIOSCIENCES
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- 巻
- 62
- 号
- 3
- 開始ページ
- 235
- 終了ページ
- 241
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.job.2020.05.005
- 出版者・発行元
- ELSEVIER
Background: The oral cavity serves as an entrance to the body and is therefore exposed to various exogenous stimuli, including mechanical forces, chemical agents, and bacterial components. The oral mucosa responds to these stimuli to maintain homeostasis and good oral health. The transient receptor potential vanilloid 1 (TRPV1) ion channel functions as an environment-sensing protein and is involved in a wide variety of cellular responses. Recent studies have revealed that epithelial TRPV1 ion channels in the oral cavity play pivotal roles in several pathophysiological conditions. In this review, we summarize the features of epithelial TRPV1 channels in the oral cavity and focus on their cellular function and pathogenicity with reference to related findings in other organs and tissues.Highlight: TRPV1 channels are widely expressed in epithelial cells in the oral cavity and play pivotal roles in fundamental cellular processes and disease progression.Conclusion: This review suggests that oral epithelial TRPV1 contributes to several cellular functions such as cell proliferation, barrier function, and inflammation. Further understanding of the characteristics of epithelial TRPV1 in the oral cavity may provide new insights into the prevention or treatment of diseases. (C) 2020 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.job.2020.05.005
- ISSN : 1349-0079
- eISSN : 1880-3865
- PubMed ID : 32544616
- Web of Science ID : WOS:000572657700003