2017年11月
Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma
ANTICANCER RESEARCH
- 巻
- 37
- 号
- 11
- 開始ページ
- 6119
- 終了ページ
- 6123
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.21873/anticanres.12060
- 出版者・発行元
- INT INST ANTICANCER RESEARCH
Background/Aim: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. Materials and Methods: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. Results: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. Conclusion: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.
- リンク情報
- ID情報
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- DOI : 10.21873/anticanres.12060
- ISSN : 0250-7005
- eISSN : 1791-7530
- PubMed ID : 29061792
- Web of Science ID : WOS:000416143900024