論文

査読有り
2010年7月

Bone Destruction by Invading Oral Squamous Carcinoma Cells Mediated by the Transforming Growth Factor-beta Signalling Pathway

ANTICANCER RESEARCH
  • Takeshi Goda
  • ,
  • Tsuyoshi Shimo
  • ,
  • Yasuto Yoshihama
  • ,
  • Nur Mohammad Monsur Hassan
  • ,
  • Soichiro Ibaragi
  • ,
  • Naito Kurio
  • ,
  • Tatsuo Okui
  • ,
  • Tatsuki Honami
  • ,
  • Koji Kishimoto
  • ,
  • Akira Sasaki

30
7
開始ページ
2615
終了ページ
2623
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
INT INST ANTICANCER RESEARCH

Background: Gingival squamous cell carcinoma (SCC) cells frequently invade mandibular bone, and this destruction is associated with a worse prognosis. However, the relationship between bone destruction and associated factors is unclear. In this study, the role and diagnostic utility of transforming growth factor-beta (TGF-beta) type I receptor (T beta RI) in bone destruction of the mandible was investigated. Patients and Methods: The expression of T beta RI was explored by using an immunohistochemical method on paraffin-embedded tissues from 21 cases of mandibular SCC. An inhibitor of the kinase activity of the T beta RI (T beta RI-I) was used to assess the role of T beta RI in bone destruction by a human oral SCC cell line (HSC-2) that highly expresses,T beta RI. Results: T beta RI-positive signals were closely associated with destructive invasion of the mandible by oral SCC cells. Consistent with these results, T beta RI-I greatly reduced HSC-2 cell-induced bone destruction and osteoclast formation in vivo and in vitro. T beta RI-I treatment reduced the expression of TNF-alpha, RANKL and connective tissue growth factor (CTGF/CCN2), all of which were up-regulated by TGF-beta in HSC-2 cells. Conclusion: These data demonstrated an important role for TGF-beta signalling in bone invasion by oral SCC cells, and suggest that the bone destruction is mediated by RANKL, TNF-alpha and CCN2.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20682990
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000280796400019&DestApp=WOS_CPL
ID情報
  • ISSN : 0250-7005
  • PubMed ID : 20682990
  • Web of Science ID : WOS:000280796400019

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