2010年7月
Bone Destruction by Invading Oral Squamous Carcinoma Cells Mediated by the Transforming Growth Factor-beta Signalling Pathway
ANTICANCER RESEARCH
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- 巻
- 30
- 号
- 7
- 開始ページ
- 2615
- 終了ページ
- 2623
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- INT INST ANTICANCER RESEARCH
Background: Gingival squamous cell carcinoma (SCC) cells frequently invade mandibular bone, and this destruction is associated with a worse prognosis. However, the relationship between bone destruction and associated factors is unclear. In this study, the role and diagnostic utility of transforming growth factor-beta (TGF-beta) type I receptor (T beta RI) in bone destruction of the mandible was investigated. Patients and Methods: The expression of T beta RI was explored by using an immunohistochemical method on paraffin-embedded tissues from 21 cases of mandibular SCC. An inhibitor of the kinase activity of the T beta RI (T beta RI-I) was used to assess the role of T beta RI in bone destruction by a human oral SCC cell line (HSC-2) that highly expresses,T beta RI. Results: T beta RI-positive signals were closely associated with destructive invasion of the mandible by oral SCC cells. Consistent with these results, T beta RI-I greatly reduced HSC-2 cell-induced bone destruction and osteoclast formation in vivo and in vitro. T beta RI-I treatment reduced the expression of TNF-alpha, RANKL and connective tissue growth factor (CTGF/CCN2), all of which were up-regulated by TGF-beta in HSC-2 cells. Conclusion: These data demonstrated an important role for TGF-beta signalling in bone invasion by oral SCC cells, and suggest that the bone destruction is mediated by RANKL, TNF-alpha and CCN2.
- リンク情報
- ID情報
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- ISSN : 0250-7005
- PubMed ID : 20682990
- Web of Science ID : WOS:000280796400019