論文

査読有り 筆頭著者 国際誌
2008年8月1日

Dynactin is essential for growth cone advance.

Biochemical and biophysical research communications
  • Takako K Abe
  • ,
  • Takao Honda
  • ,
  • Kohtaro Takei
  • ,
  • Katsuhiko Mikoshiba
  • ,
  • Diane Hoffman-Kim
  • ,
  • Daniel G Jay
  • ,
  • Ryozo Kuwano

372
3
開始ページ
418
終了ページ
22
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2008.05.008

Dynactin is a multi-subunit complex that serves as a critical cofactor of the microtubule motor cytoplasmic dynein. We previously identified dynactin in the nerve growth cone. However, the function of dynactin in the growth cone is still unclear. Here we show that dynactin in the growth cone is required for constant forward movement of the growth cone. Chromophore-assisted laser inactivation (CALI) of dynamitin, a dynactin subunit, within the growth cone markedly decreases the rate of growth cone advance. CALI of dynamitin in vitro dissociates another dynactin subunit, p150(Glued), from dynamitin. These results indicate that dynactin, especially the interaction between dynamitin and p150(Glued), plays an essential role in growth cone advance.

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2008.05.008
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18477476
ID情報
  • DOI : 10.1016/j.bbrc.2008.05.008
  • PubMed ID : 18477476

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