和久剛 (Tsuyoshi Waku) - マイポータル

基本情報

所属: 同志社大学生命医科学部医生命システム学科准教授

学位: 博士（理学）(大阪大学)

J-GLOBAL ID: 201501018057203547
researchmap会員ID: 7000012226

研究キーワード

研究分野

経歴

2021年4月 - 現在

同志社大学, 生命医科学部, 准教授
2015年4月 - 2021年3月

同志社大学, 生命医科学部, 助教
2012年4月 - 2015年3月

東京大学大学院, 薬学研究科, 日本学術振興会特別研究員
2011年4月 - 2012年3月

筑波大学, 生命領域学際研究センター, 博士研究員
2009年4月 - 2011年3月

大阪大学, 蛋白質研究所, 博士研究員

学歴

論文

Localization of p210 <scp>BCR</scp> ‐ <scp>ABL</scp> to the Mitochondria Promotes Chronic Myeloid Leukemia Cell Proliferation Through c <scp>IAP</scp> Signaling

Aoi Ikegami, Miho Watanabe‐Takahashi, Kentaro Shimasaki, Yuta Okuda, Masaya Choda, Tsuyoshi Waku, Yoshiro Maru, Atsuko Deguchi, Yuri Nishino, Atsuo Miyazawa …

The FASEB Journal 40(11) 2026年5月30日査読有り
Clustered peptide regulating the multivalent interaction between RANK and TRAF6 inhibits osteoclastogenesis by fine-tuning signals

Masataka Anzai, Miho Watanabe-Takahashi, Hiroshi Kawabata, Yuri Masuda, Aoi Ikegami, Yuta Okuda, Tsuyoshi Waku, Hiroaki Sakurai, Keizo Nishikawa, Jun-ichiro Inoue …

Communications Biology 8(1) 2025年4月22日査読有り
The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis.

Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, Akira Kobayashi

Scientific reports 13(1) 14405-14405 2023年9月1日査読有り
NRF3 activates mTORC1 arginine-dependently for cancer cell viability

Shuuhei Hirose, Tsuyoshi Waku, Misato Tani, Haruka Masuda, Keiko Endo, Sanae Ashitani, Iori Aketa, Hina Kitano, Sota Nakada, Ayaka Wada …

iScience 26(2) 106045-106045 2023年2月査読有り責任著者
The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation

Tsuyoshi Waku, Sota Nakada, Haruka Masuda, Haruna Sumi, Ayaka Wada, Shuuhei Hirose, Iori Aketa, Akira Kobayashi

Cell Reports 42(1) 111906 2023年1月査読有り筆頭著者責任著者
Nrf3 Functions Reversely as a Tumorigenic to an Antitumorigenic Transcription Factor in Obese Mice

Tsuyoshi Waku, Takuya Iwami, Haruka Masuda, Shuuhei Hirose, Iori Aketa, Akira Kobayashi

The Tohoku Journal of Experimental Medicine 259(1) 1-8 2022年12月査読有り筆頭著者
Pathophysiological Potentials of NRF3-Regulated Transcriptional Axes in Protein and Lipid Homeostasis

Tsuyoshi Waku, Akira Kobayashi

International Journal of Molecular Sciences 22(23) 12686-12686 2021年11月24日査読有り筆頭著者
NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition

Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi …

iScience 24(10) 103180 2021年10月査読有り筆頭著者
NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression

Tsuyoshi Waku, Hiroyuki Katayama, Miyako Hiraoka, Atsushi Hatanaka, Nanami Nakamura, Yuya Tanaka, Natsuko Tamura, Akira Watanabe, Akira Kobayashi

Molecular and Cellular Biology 40(14) e00010-20 2020年6月29日査読有り筆頭著者
NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein

Tsuyoshi Waku, Nanami Nakamura, Misaki Koji, Hidenori Watanabe, Hiroki Katoh, Chika Tatsumi, Natsuko Tamura, Atsushi Hatanaka, Shuuhei Hirose, Hiroyuki Katayama …

Molecular and Cellular Biology 40(10) e00597-19 2020年4月28日査読有り筆頭著者
The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection

Jumpei Omi, Miho Watanabe-Takahashi, Katsura Igai, Eiko Shimizu, Ching-Yi Tseng, Tomohiro Miyasaka, Tsuyoshi Waku, Shinichiro Hama, Rieka Nakanishi, Yuki Goto …

Nature Communications 11(1) 2020年1月9日査読有り
New addiction to the NRF2‐related factor NRF3 in cancer cells: Ubiquitin‐independent proteolysis through the 20S proteasome

Akira Kobayashi, Tsuyoshi Waku

Cancer Science 111(1) 6-14 2020年1月査読有り招待有り
β-Catenin/TCF4 Complex-Mediated Induction of the NRF3 (NFE2L3) Gene in Cancer Cells

Shiori Aono, Ayari Hatanaka, Atsushi Hatanaka, Yue Gao, Yoshitaka Hippo, Makoto Mark Taketo, Tsuyoshi Waku, Akira Kobayashi

International Journal of Molecular Sciences 20(13) 3344-3344 2019年7月8日査読有り
Klf5 suppresses ERK signaling in mouse pluripotent stem cells

Takuya Azami, Ken Matsumoto, Hyojung Jeon, Tsuyoshi Waku, Masafumi Muratani, Hitoshi Niwa, Satoru Takahashi, Masatsugu Ema

PLOS ONE 13(11) e0207321-e0207321 2018年11月19日査読有り
Solution exploration using multi-objective genetic algorithm for determining experiment candidate.

Lorenzo Perino, Akihiro Fujii, Tsuyoshi Waku, Akira Kobayashi, Satoru Hiwa, Tomoyuki Hiroyasu

Proceedings of the Genetic and Evolutionary Computation Conference Companion, GECCO 2018, Kyoto, Japan, July 15-19, 2018 1584-1589 2018年査読有り
Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation

A. M. Masudul Azad Chowdhury, Hiroki Katoh, Atsushi Hatanaka, Hiroko Iwanari, Nanami Nakamura, Takao Hamakubo, Tohru Natsume, Tsuyoshi Waku, Akira Kobayashi

Scientific Reports 7(1) 12494 2017年10月2日査読有り
Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes

Hiroaki Taniguchi, Shota Okamuro, Misaki Koji, Tsuyoshi Waku, Kaori Kubo, Atsushi Hatanaka, Yimeng Sun, A.M. Masudul Azad Chowdhury, Akiyoshi Fukamizu, Akira Kobayashi

Biochemical and Biophysical Research Communications 484(1) 176-183 2017年2月査読有り
Klf5 maintains the balance of primitive endoderm to epiblast specification during mouse embryonic development by suppression of Fgf4

Takuya Azami, Tsuyoshi Waku, Ken Matsumoto, Hyojung Jeon, Masafumi Muratani, Akihiro Kawashima, Jun Yanagisawa, Ichiro Manabe, Ryozo Nagai, Tilo Kunath …

Development 144(20) 3706-3718 2017年1月1日査読有り
Hypermethylation of the CaSR and VDR genes in the parathyroid glands in chronic kidney disease rats with high-phosphate diet

Taketo Uchiyama, Norifumi Tatsumi, Sahoko Kamejima, Tsuyoshi Waku, Ichiro Ohkido, Keitaro Yokoyama, Takashi Yokoo, Masataka Okabe

Human Cell 29(4) 155-161 2016年10月査読有り
Regulation of the vitamin D receptor by vitamin D lactam derivatives

Lisa Asano, Tsuyoshi Waku, Rumi Abe, Naoyuki Kuwabara, Ichiaki Ito, Junn Yanagisawa, Kazuo Nagasawa, Toshiyuki Shimizu

FEBS Letters 590(18) 3270-3279 2016年9月査読有り筆頭著者