論文

査読有り 国際誌
2019年

Simplified Dynamic Phantom for Pediatric Renography: A Description of Instrument and its Performance.

Asia Oceania journal of nuclear medicine & biology
  • Takashi Kamiya
  • Tadashi Watabe
  • Koichi Fujino
  • Romanov Victor
  • Yoshiki Kawamura
  • Kayako Isohashi
  • Keiko Matsunaga
  • Mitsuaki Tatsumi
  • Hiroki Kato
  • Eku Shimosegawa
  • Jun Hatazawa
  • 全て表示

7
1
開始ページ
38
終了ページ
48
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.22038/AOJNMB.2018.11803

Objectives: Renography is used for the diagnostic evaluation of pediatric patients with a suspected obstruction of urinary tract or impaired renal function. The recommended dose for children have been released by the European Association of Nuclear Medicine, Society of Nuclear Medicine and Molecular Imaging, and Japanese Society of Nuclear Medicine. Since acquisition counts in dynamic scintigraphy are affected by the administered doses and sensitivity of the scintillation camera, the scan procedure should be determined independently. In this study, we constructed simplified dynamic phantom imitating pediatric renography and tested its performance. Methods: Simplified dynamic phantom consisted of three components (i.e., infusion, imitated kidney, and drainage sections). The infusion rates (mL/min) were determined by comparing the time activity curves obtained from patients with normal renal function. The time-points of the maximum counts (Tmax), as well as the two-thirds and one-half of the maximum counts (T2/3 and T1/2) were measured in different doses using the phantom with the best-match infusion rate and duration, and low-energy general-purpose (LEGP) or low-energy high-resolution (LEHR) collimators and applying different attenuations. Results: The best-match infusion rates of the phantom to imitate the time activity curve of the normal renal function were 42.0, 1.0, 0.6, and 0.3 mL/min in the arterial, secretory, early-excretory, and late-excretory phases, respectively. When 30 MBq, LEHR collimator and non-water-equivalent phantom were applied, Tmax, T2/3, and T1/2 were 242±15.3, 220±10.0 and 317±25.2 seconds, respectively. Using LEGP collimator and (3 MBq of activity) 5-cm water-equivalent phantom, Tmax, T2/3, and T1/2 values were estimated as 242±5.8, 213±11.5, and 310±17.3 sec, respectively. Conclusion: Our simplified dynamic phantom for pediatric renography could imitate the time activity curves obtained from patients with normal renal function. Tmax, T2/3, and T1/2 could be measured under various settings of dose, collimator, and tissue attenuation.

リンク情報
DOI
https://doi.org/10.22038/AOJNMB.2018.11803
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30705910
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352048
ID情報
  • DOI : 10.22038/AOJNMB.2018.11803
  • ISSN : 2322-5718
  • PubMed ID : 30705910
  • PubMed Central 記事ID : PMC6352048

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