論文

査読有り
2013年12月

Spatial Distribution of Selection Pressure on a Protein Based on the Hierarchical Bayesian Model

MOLECULAR BIOLOGY AND EVOLUTION
  • Teruaki Watabe
  • ,
  • Hirohisa Kishino

30
12
開始ページ
2714
終了ページ
2722
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/molbev/mst151
出版者・発行元
OXFORD UNIV PRESS

Proteins adapt to novel environments and/or gain function by substitution in amino acid sequences. Therefore, mutations in protein-coding genes are subject to selection pressure. The strength and character of selection pressure may vary among the regions of the protein. Thus, the spatial distribution of selection pressure provides information on the adaptive evolution of the protein. We developed a hierarchical Bayesian model that detects the spatial distribution of selection pressure on a protein. We expressed selection pressure by the substitution rate ratio of nonsynonymous to synonymous substitutions in the DNA sequence. The Potts model describes the prior distribution of spatial aggregation of selection pressure. The hyperparameters that define the strength and range of spatial clustering are estimated by maximizing the marginal likelihood. Because our prior distribution is un-normalized, we calculated the log marginal likelihood by "thermodynamic integration." We applied the method to historical data on the influenza hemagglutinin protein, comparing the estimated spatial distribution of the substitution rate ratio with that of antigenic sites A-E. The amino acid residues with higher substitution rate ratios, representing diversifying selection pressure, overlapped the antigenic sites.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1093/molbev/mst151
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000327793000017&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/molbev/mst151
  • ISSN : 0737-4038
  • eISSN : 1537-1719
  • Web of Science ID : WOS:000327793000017

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