2012年4月
Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
JOURNAL OF NEUROENDOCRINOLOGY
- ,
- ,
- 巻
- 24
- 号
- 4
- 開始ページ
- 587
- 終了ページ
- 598
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1111/j.1365-2826.2012.02300.x
- 出版者・発行元
- WILEY-BLACKWELL
Oxytocin neurones are activated by stressful stimuli, food intake and social attachment. Activation of oxytocin neurones in response to stressful stimuli or food intake is mediated, at least in part, by noradrenaline/prolactin-releasing peptide (PrRP) neurones in the nucleus tractus solitarius, whereas oxytocin neurones are activated after social stimuli via medial amygdala neurones. Activation of oxytocin neurones induces the release of oxytocin not only from their axon terminals, but also from their dendrites. Oxytocin acts locally where released or diffuses and acts on remote oxytocin receptors widely distributed within the brain, resulting in anxiolytic, anorexic and pro-social actions. The action sites of oxytocin appear to be multiple. Oxytocin shows anxiolytic actions, at least in part, via serotoninergic neurones in the median raphe nucleus, has anorexic actions via pro-opiomelanocortin neurones in the nucleus tractus solitarius and facilitates social recognition via the medial amygdala. Stress, obesity and social isolation are major risk factors for mortality in humans. Thus, the oxytocinoxytocin receptor system is a therapeutic target for the promotion of human health.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1365-2826.2012.02300.x
- ISSN : 0953-8194
- PubMed ID : 22353547
- Web of Science ID : WOS:000301925100007