Motokazu Uchigashima

Profile Information

Affiliation: Brain Research Institute Basic Neuroscience Branch Department of Cellular Neurobiology, Niigata University

Degree: 博士（医学）(北海道大学)

Researcher number: 10614662
J-GLOBAL ID: 201101093735172136
researchmap Member ID: B000003320

Research Interests

Research Areas

Research History

Oct, 2021 - Present

Affiliated Faculty, International Research Center for Neurointelligence, The University of Tokyo Institutes for Advanced Study
Mar, 2019 - Present

Brain Research Institute, Niigata University
Apr, 2017 - Feb, 2019

Hokkaido University
Feb, 2016 - Mar, 2018

Visiting Scholar, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School
Apr, 2011 - Mar, 2017

Graduate School of Medicine, Hokkaido University
Apr, 2001 - Mar, 2007

School of Medicine, Hokkaido University

Awards

Sep, 2022

新潟大学学長賞（若手教員研究奨励）, 新潟大学
Feb, 2022

フラテ研究奨励賞, 北海道大学医学部同窓会
Dec, 2021

新潟大学優秀論文表彰, 新潟大学
Aug, 2021

新潟大学学長賞, 新潟大学
Dec, 2020

エクセレントティーチャー優秀賞, 北海道大学医学部
Sep, 2018

ベストプレゼンテーション賞, 孤束核・分界条床核投射系のノルアドレナリン/グルタミン酸共放出ニューロンがもたらすユニークな神経伝達の分子形態学的基盤, 第64回日本解剖学会東北・北海道連合支部学術集会

内ヶ島基政
Feb, 2017

優秀論文賞, Dopamine synapse is a neuroligin-2–mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures, 北海道大学大学院医学研究科

内ヶ島基政
Dec, 2015

若手優秀発表賞, Stratal dopamine synapses are neuroligin-2-mediated heterologous contacts between dopaminergic pre synapse and GABAergic post synapse, 包括脳ネットワーク

内ヶ島基政
2014

優秀教員賞, 北海道大学医学部

内ヶ島基政
Feb, 2010

第15回グリアクラブ賞, Molecular-anatomical architecture of 2-arachidonoyl-glycerol-mediated retrograde signaling in the mossy cell-recipient dentate molecular layer

内ヶ島基政
Dec, 2007

奨励賞, マウス線条体における内因性カンナビノイド 2-アラキドノイルグリセロールを介した逆行性伝達抑制の分子機構, 日本顕微鏡学会北海道支部

内ヶ島基政
2006

音羽博次奨学基金, 北海道大学大学院医学研究科

内ヶ島基政

Papers

General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process.

Kenjiro Hanaoka, Shimpei Iwaki, Kiyoshi Yagi, Takuya Myochin, Takayuki Ikeno, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Motokazu Uchigashima …

Journal of the American Chemical Society, 144(43) 19778-19790, Oct 3, 2022 Peer-reviewed
Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction

Motokazu Uchigashima, Amy Cheung, Kensuke Futai

Frontiers in Molecular Neuroscience, 14 749164-749164, Oct 6, 2021 Peer-reviewedInvitedLead authorCorresponding author
Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus.

Motokazu Uchigashima, Kohtarou Konno, Emily Demchak, Amy Cheung, Takuya Watanabe, David G Keener, Manabu Abe, Timmy Le, Kenji Sakimura, Toshikuni Sasaoka …

eLife, 9, Dec 23, 2020 Peer-reviewedLead author
Enhanced Retrieval of Taste Associative Memory by Chemogenetic Activation of Locus Coeruleus Norepinephrine Neurons.

Ryoji Fukabori, Yoshio Iguchi, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Shingo Tsuji, Akihiro Hazama, Motokazu Uchigashima, Masahiko Watanabe, Hiroshi Mizuma …

The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(43) 8367-8385, Oct 21, 2020 Peer-reviewed
Neuroligin3 splice isoforms shape inhibitory synaptic function in the mouse hippocampus.

Motokazu Uchigashima, Ming Leung, Takuya Watanabe, Amy Cheung, Timmy Le, Sabine Pallat, Alexandre Luis Marques Dinis, Masahiko Watanabe, Yuka Imamura Kawasawa, Kensuke Futai

The Journal of biological chemistry, 295(25) 8589-8595, Jun 19, 2020 Peer-reviewedLead author
Methodological approaches to understand the molecular mechanism of structural plasticity of dendritic spines.

Takayasu Mikuni, Motokazu Uchigashima

The European journal of neuroscience, 54(8) 6902-6911, Apr 5, 2020 Invited
Differential expression of neurexin genes in the mouse brain.

Motokazu Uchigashima, Amy Cheung, Julie Suh, Masahiko Watanabe, Kensuke Futai

The Journal of comparative neurology, 527(12) 1940-1965, Aug 15, 2019 Peer-reviewedLead authorCorresponding author
Endocannabinoid and nitric oxide systems of the hypothalamic paraventricular nucleus mediate effects of NPY on energy expenditure.

Zoltán Péterfi, Imre Farkas, Raphael G P Denis, Erzsébet Farkas, Motokazu Uchigashima, Tamás Füzesi, Masahiko Watanabe, Ronald M Lechan, Zsolt Liposits, Serge Luquet …

Molecular metabolism, 18 120-133, Dec, 2018 Peer-reviewed
Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways.

Satoshi Nonomura, Kayo Nishizawa, Yutaka Sakai, Yasuo Kawaguchi, Shigeki Kato, Motokazu Uchigashima, Masahiko Watanabe, Ko Yamanaka, Kazuki Enomoto, Satomi Chiken …

Neuron, 99(6) 1302-1314, Sep 19, 2018 Peer-reviewed
Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1

Wenjie Mao, Anna C. Salzberg, Motokazu Uchigashima, Yuto Hasegawa, Hanno Hock, Masahiko Watanabe, Schahram Akbarian, Yuka Imamura Kawasawa, Kensuke Futai

Cell Reports, 23(11) 3209-3222, Jun 12, 2018 Peer-reviewed
Endocytosis following dopamine D-2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFR beta signaling in striatopallidal medium spiny neurons

N. Shioda, Y. Yabuki, Y. Wang, M. Uchigashima, T. Hikida, T. Sasaoka, H. Mori, M. Watanabe, M. Sasahara, K. Fukunaga

MOLECULAR PSYCHIATRY, 22(8) 1205-1222, Aug, 2017 Peer-reviewed
LUsing a novel PV-Cre rat model to characterize pallidonigral cells and their terminations

Yoon-Mi Oh, Fuyuki Karube, Susumu Takahashi, Kenta Kobayashi, Masahiko Takada, Motokazu Uchigashima, Masahiko Watanabe, Kayo Nishizawa, Kazuto Kobayashi, Fumino Fujiyama

BRAIN STRUCTURE & FUNCTION, 222(5) 2359-2378, Jul, 2017 Peer-reviewed
Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, Goal-Directed Behavior Independently of D1 and D2 Selectivity

Akiyo Natsubori, Iku Tsutsui-Kimura, Hiroshi Nishida, Youcef Bouchekioua, Hiroshi Sekiya, Motokazu Uchigashima, Masahiko Watanabe, Alban de Kerchove d'Exaerde, Masaru Mimura, Norio Takata …

JOURNAL OF NEUROSCIENCE, 37(10) 2723-2733, Mar, 2017 Peer-reviewed
Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation

Iku Tsutsui-Kimura, Hiroyuki Takiue, Keitaro Yoshida, Ming Xu, Ryutaro Yano, Hiroyuki Ohta, Hiroshi Nishida, Youcef Bouchekioua, Hideyuki Okano, Motokazu Uchigashima …

Nature Communications, 8 14304, Feb, 2017 Peer-reviewed
The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus

Madoka Narushima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata …

NEURON, 91(5) 1097-1109, Sep, 2016 Peer-reviewed
Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures

Yuki Sugaya, Maya Yamazaki, Motokazu Uchigashima, Kenta Kobayashi, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano

CELL REPORTS, 16(5) 1405-1415, Aug, 2016 Peer-reviewed
Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins

Keiko Matsuda, Timotheus Budisantoso, Nikolaos Mitakidis, Yuki Sugaya, Eriko Miura, Wataru Kakegawa, Miwako Yamasaki, Kohtarou Konno, Motokazu Uchigashima, Manabu Abe …

NEURON, 90(4) 752-767, May, 2016 Peer-reviewed
Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures

Motokazu Uchigashima, Toshihisa Ohtsuka, Kazuto Kobayashi, Masahiko Watanabe

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(15) 4206-4211, Apr, 2016 Peer-reviewed
Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo

Taku Nagai, Shinichi Nakamuta, Keisuke Kuroda, Sakura Nakauchi, Tomoki Nishioka, Tetsuya Takano, Xinjian Zhang, Daisuke Tsuboi, Yasuhiro Funahashi, Takashi Nakano …

NEURON, 89(3) 550-565, Feb, 2016 Peer-reviewed
Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination

Ryoichi Ichikawa, Kouichi Hashimoto, Taisuke Miyazaki, Motokazu Uchigashima, Miwako Yamasaki, Atsu Aiba, Masanobu Kano, Masahiko Watanabe

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(8) 2282-2287, Feb, 2016 Peer-reviewed

Misc.

青斑核ノルアドレナリン神経細胞の活動亢進による情動記憶の想起の促進新規神経活動活性化ツールによる検討

井口善生, 深堀良二, 加藤成樹, 高橋和巳, 永福智志, 辻真伍, 挾間章博, 内ヶ島基政, 渡辺雅彦, 水間広 …

日本生理学雑誌, 83(2) 39-39, May, 2021
Enhanced emotional memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons

Fukabori, R, Iguchi, Y, Kato, S, Takahashi, K, Eifuku, S, Tsuji, S, Hazama, A, Uchigashima, M, Watanabe, M, Mizuma, H …

Mendeley Data, Nov, 2019
Requirement of mGluR1 for Experience-Dependent Remodeling of Mouse Retinogeniculate Synapses

M. Kano, M. Narushima, M. Uchigashima, M. Watanabe, A. Aiba, M. Miyata

CURRENT NEUROPHARMACOLOGY, 12 30-31, 2014
Lack of Molecular-Anatomical Evidence for GABAergic Influence on Axon Initial Segment of Cerebellar Purkinje Cells by the Pinceau Formation

87(6) 273-273, Nov 1, 2012
Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus

87(2) 72-72, Apr 1, 2012
Unique inhibitory Synapse with Particularly Rich Endocannabinoid Signaling Machinery on Pyramidal Neurons in Basal Amygdaloid Nucleus

T. Yoshida, M. Uchigashima, M. Yamasaki, I. Katona, M. Yamazaki, K. Sakimura, M. Kano, M. Yoshioka, M. Watanabe

CURRENT NEUROPHARMACOLOGY, 9 68-68, Sep, 2011
Synapse "non-specific" degradation of the endocannabinoid 2-arachidonoylglycerol mediating depolarization-induced retrograde synaptic suppression in cerebellar Purkinje cells

Asami Tanimura, Maya Yamazaki, Motokazu Uchigashima, Naofumi Uesaka, Takayasu Mikuni, Kouichi Hashimoto, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano

NEUROSCIENCE RESEARCH, 71 E56-E56, 2011
Behavioral role of thalamostriatal neural pathway in conditional discrimination paradigm

Shigeki Kato, Masahito Kuramochi, Kenta Kobayashi, Ryoji Fukabori, Motokazu Uchigashima, Masahiko Watanabe, Yuji Tsutsui, Kazuto Kobayashi

NEUROSCIENCE RESEARCH, 71 E280-E280, 2011
Immunohistochemical characterization of dopaminergic synapses in the mouse striatum

Motokazu Uchigashima, Masahiko Watanabe

NEUROSCIENCE RESEARCH, 71 E111-E111, 2011
Striatal direct pathway modulates response time in execution of conditional discrimination

Ryoji Fukabori, Kana Okada, Kayo Nishizawa, Nobuyuki Kai, Kenta Kobayashi, Motokazu Uchigashima, Masahiko Watanabe, Yuji Tsutsui, Kazuto Kobayashi

NEUROSCIENCE RESEARCH, 71 E379-E380, 2011
2-Arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission in the CNS

Asami Tanimura, Maya Yamazaki, Yuki Hashimotodani, Motokazu Uchigashima, Shinya Kawata, Manabu Abe, Yoshihiro Kita, Kouichi Hashimoto, Takao Shimizu, Masahiko Watanabe …

NEUROSCIENCE RESEARCH, 68 E88-E88, 2010
Role of the striatonigral neurons in basal ganglia in the performance of conditional discrimination task

Ryoji Fukabori, Kana Okada, Nobuyuki Kai, Kenta Kobayashi, Yuji Tsutsui, Motokazu Uchigashima, Masahiko Watanebe, Kazuto Kobayashi

NEUROSCIENCE RESEARCH, 68 E185-E185, 2010
Molecular-anatomical basis for the spread of endocannabinoid 2-arachidonoylglycerol at mossy cell-granule cell synapses in the dentate gyrus

Motokazu Uchigashima, Masahiko Watanabe

NEUROSCIENCE RESEARCH, 68 E55-E55, 2010
Molecular mechanism of endocannabinoid-mediated retrograde signaling in basolateral amygdala

Takayuki Yoshida, Motokazu Uchigashima, Hiroki Shikanai, Takashi Izumi, Taku Yamaguchi, Masahiko Watanabe, Mitsuhiro Yoshioka

JOURNAL OF PHARMACOLOGICAL SCIENCES, 112 62P-62P, 2010
Endocannabinoid and serotonin modulate GABAergic and glutamatergic transmission in the basolateral amygdala

Takayuki Yoshida, Motokazu Uchigashima, Takeshi Izumi, Taku Yamaguchi, Masanobu Kano, Masahiko Watanabe, Mitsuhiro Yoshioka

NEUROSCIENCE RESEARCH, 68 E229-E229, 2010
Role of the striatopallidal neurons in basal ganglia in the performance of conditional discrimination task

Kayo Nishizawa, Ryoji Fukabori, Nobuyuki Kai, Yuji Tsutsui, Motokazu Uchigashima, Masahiko Watanebe, Akira Shiota, Masatsugu Ueda, Kazuto Kobayashi

NEUROSCIENCE RESEARCH, 68 E185-E185, 2010
The role of dopamine D-2 receptor-expressing neurons in the nucleus accumbens core in operant matching

Nobuyuki Kai, Ryoji Fukabori, Yuji Tsutsui, Motokazu Uchigashima, Masahiko Watanebe, Akira Shiota, Masatsugu Ueda, Kazuto Kobayashi

NEUROSCIENCE RESEARCH, 68 E289-E290, 2010
Retrograde signalling is induced by endocannabinoids in the basolateral amygdala

Takayuki Yoshida, Motokazu Uchigashima, Hiroki Shikanai, Takashi Izumi, Taku Yamaguchi, Masahiko Watanabe, Mitsuhiro Yoshioka

JOURNAL OF PHARMACOLOGICAL SCIENCES, 109 220P-220P, 2009
IMMUNOHISTOCHEMICAL LOCALIZATION OF MOLECULES FOR 2-ARACHIDONOYLGLYCEROL-MEDIATED RETROGRADE SIGNALING IN THE MOUSE DENTATE GYRUS

Motokazu Uchigashima, Masahiko Watanabe

JOURNAL OF PHYSIOLOGICAL SCIENCES, 59 146-146, 2009
Involvement of type 1 metabotoropic glutamate receptor in developmental synapse elimination in the lateral geniculate nucleus

Madoka Narushima, Uchigashima Motokazu, Asami Tanimura, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Masanobu Kano

NEUROSCIENCE RESEARCH, 61 S57-S57, 2008

Teaching Experience

Research Projects

Inducing lifelong plasticity (iPlasticity) by brain rejuvenation: elucidation and manipulation of critical period mechanisms

Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A), Grant-in-Aid for Transformative Research Areas (A), Japan Society for the Promotion of Science, Nov, 2020 - Mar, 2025
Analysis of Molecular Dynamics for Structural Spine Plasticity during the Critical Period

Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A), Grant-in-Aid for Transformative Research Areas (A), Japan Society for the Promotion of Science, Nov, 2020 - Mar, 2025
線条体中型有棘ニューロンにおけるドーパミン伝達の時空間的統合過程の理解

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

内ヶ島基政
Development of a novel method for analyzing the distribution of endogenous proteins in mammalian brain tissues

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Uchigashima Motokazu
ドーパミンシナプスの生細胞イメージングを介したドーパミン神経伝達の理解

研究助成, 興和生命科学振興財団, Jan, 2020 - Dec, 2020

内ヶ島基政
ドーパミンシナプスの構造的可塑性に関する研究

若手研究者研究加速事業, 北海道大学, 2018

内ヶ島基政
Molecular-anatomical research on multi-modal regulation of synaptic transmission in higher brain regions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2012 - Mar, 2017

WATANABE MASAHIKO, Yamasaki Miwako, Miyazaki Taisuke, Konno Kohtarou, Uchigashima Motokazu, Kano Masanobu, Shigemoto Ryuichi, Kobayashi Kazuto
Study of the molecular-anatomical basis common to neuromodulatory synapses

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2015 - 2017

Uchigashima Motokazu
Histological study of functional molecules involved in acquirement of developmental function for eating

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

TAKASAKI Chihiro, UCHIGASHIMA Motokazu, WATANABE Masahiko
Functional morphology of dopamine synapses in the mouse striatum

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2013 - 2014

UCHIGASHIMA Motokazu
Analysis for endocannabinoid signaling in the epileptogenic circuit

Grants-in-Aid for Scientific Research(研究活動スタート支援), 研究活動スタート支援, 研究活動スタート支援, Ministry of Education, Culture, Sports, Science and Technology, 2011 - 2012

Motokazu UCHIGASHIMA

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