2014年10月
Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis
JOURNAL OF VETERINARY MEDICAL SCIENCE
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- 巻
- 76
- 号
- 10
- 開始ページ
- 1407
- 終了ページ
- 1410
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1292/jvms.13-0635
- 出版者・発行元
- JAPAN SOC VET SCI
Lymphocytic-plasmacytic colitis (LPC) is a common form of inflammatory bowel disease (IBD) affecting the canine large intestine. Cytokines are thought to be involved in the pathogenesis of IBD. However, to date, few studies have investigated cytokine mRNA expression in dogs with LPC. In this study, we investigated mRNA transcription levels of T helper cell cytokines, such as IFN-gamma, IL-4, IL-17 and IL-10 and pro-inflammatory cytokines, such as IL-1 beta, IL-6, TNF-alpha., IL-8, IL-12 and IL-23, in colonic mucosa from LPC dogs by quantitative real-time RT-PCR. No significant differences were detected in cytokine mRNA expressions between dogs with LPC and controls, except for IL-23p19. Dogs with LPC failed to express a predominant cytokine profile in inflamed colonic mucosa as opposed to human IBD.
- リンク情報
- ID情報
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- DOI : 10.1292/jvms.13-0635
- ISSN : 0916-7250
- eISSN : 1347-7439
- PubMed ID : 24976586
- Web of Science ID : WOS:000343784200015