論文

査読有り 筆頭著者 責任著者 国際誌
2020年11月

Spatial Patterns of Amyloid Deposition in Patients with Chronic Focal or Diffuse Traumatic Brain Injury Using 18F-FPYBF-2 PET</p>

Neuropsychiatric Disease and Treatment
  • Shiho Ubukata
  • Naoya Oishi
  • Tatsuya Higashi
  • Shinya Kagawa
  • Hiroshi Yamauchi
  • Chio Okuyama
  • Hiroyuki Watanabe
  • Masahiro Ono
  • Hideo Saji
  • Toshihiko Aso
  • Toshiya Murai
  • Keita Ueda
  • 全て表示

Volume 16
開始ページ
2719
終了ページ
2732
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2147/ndt.s268504
出版者・発行元
Informa UK Limited

Aim: Amyloid-β (Aβ) accumulation, accelerated by traumatic brain injury (TBI), may play a crucial role in neurodegeneration in chronic-stage TBI. The injury type could influence Aβ dynamics because of TBI's complex, heterogeneous nature. We, therefore, investigated spatial patterns of amyloid deposition according to injury type after TBI using 5-(5-(2-(2-(2-[F]-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylpyridin-2-amine (18F-FPYBF-2) positron emission tomography (PET). Methods: Altogether, 20 patients with chronic TBI [12 with focal injury, 8 with diffuse axonal injury (DAI)] underwent 18F-FPYBF-2 PET, structural magnetic resonance imaging (MRI), and neuropsychological examination. Additionally, 50 healthy controls underwent either 18F-FPYBF-2 PET (n=30) or structural MRI (n=20). Results: Standardized uptake value ratio (SUVR) on PET images and regional brain volumes were measured in four cortical (frontal, parietal, occipital, temporal) and subcortical (combined caudate, putamen, pallidum, thalamus) regions. Patients with DAI showed significantly increased (compared with controls) SUVR in occipital and temporal cortices and decreased brain volume in occipital cortex (corrected p < 0.05). Although patients with focal injury showed decreased SUVR in all regions except occipital cortex, there were no significant differences (compared with controls) in the SUVR in any regions. There were no significant correlations between increased SUVR and neuropsychological impairments in patients with DAI. Conclusion: Varying spatial patterns of amyloid deposition suggest amyloid pathology diversity depending on the injury type in chronic-TBI patients.

リンク情報
DOI
https://doi.org/10.2147/ndt.s268504
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33209027
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669502
URL
https://www.dovepress.com/getfile.php?fileID=63652
ID情報
  • DOI : 10.2147/ndt.s268504
  • eISSN : 1178-2021
  • PubMed ID : 33209027
  • PubMed Central 記事ID : PMC7669502

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