We investigated changes in the microstructure and mechanical properties of biomedical Co20Cr15W10Ni alloys (mass%) containing 8 mass% Mn and 03 mass% Si due to hot forging, solution treatment, cold swaging, and static recrystallization. The ©-phase (M XM X type cubic structure, M: metallic elements, X: C and/or N, space group: Fd-3m (227)) and CoWSi type Laves phase (C14 MgZn2 type hexagonal structure, space group: P63/mmc (194)) were confirmed as precipitates in the as-cast and as-forged alloys. To the best of our knowledge, this is the first report that reveals the formation of CoWSi type Laves phase precipitates in CoCrWNi-based alloys. The addition of Si promoted the formation of precipitates of both ©-phase and CoWSi type Laves phase. The solution-treated 8Mn+(0, 1)Si-added alloys exhibited TWIP-like plastic deformation behavior with an increasing work-hardening rate during the early to middle stages of plastic deformation. This plastic deformation behavior is effective in achieving both the low yield stress and high strength required to develop a high-performance balloon-expandable stent. The 8Mn+2Si-added alloy retained the CoWSi type Laves phase even after solution treatment, such that the ductility decreased but the strength improved. Additions of Mn and Si are effective in improving the ductility and strength of the CoCrWNi alloy, respectively. 6 12