Takashi Umehara

J-GLOBAL         Last updated: May 1, 2019 at 00:00
 
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Name
Takashi Umehara
E-mail
takashi.umeharariken.jp
URL
http://www.riken.jp/en/research/labs/bdr/epigen_drug_discov/
Affiliation
RIKEN
Section
Laboratory for Epigenetics Drug Discovery
Job title
Team Leader
Degree
Ph.D.(The University of Tokyo)

Research Areas

 
 

Academic & Professional Experience

 
2019
 - 
Today
Team Leader, RIKEN
 
2013
 - 
2019
Unit Leader, RIKEN
 
2007
 - 
2013
Senior Scientist, RIKEN
 
2005
 - 
2007
Research Scientist, RIKEN
 
2003
 - 
2005
Research Associate, RIKEN
 
2001
 - 
2003
Research Manager, Japan Science and Technology Agency
 
1999
 - 
2001
Research Fellow, Japan Science and Technology Agency
 

Education

 
1994
 - 
1999
Graduate School of Pharmaceutical Sciences, The University of Tokyo
 
1990
 - 
1994
Faculty of Pharmaceutical Sciences, The University of Tokyo
 

Awards & Honors

 
2011
Young Investigator Award, The Japanese Society for Epigenetics
 

Published Papers

 
Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H
Journal of Medicinal Chemistry   62(7) 3407-3427   Apr 2019   [Refereed]
Saito S, Kikuchi J, Koyama D, Sato S, Koyama H, Osada N, Kuroda Y, Akahane K, Inukai T, Umehara T, Furukawa Y
Clinical Cancer Research   25(5) 1601-1611   Mar 2019   [Refereed]
Umezawa N, Tsuji K, Sato S, Kikuchi M, Watanabe H, Horai Y, Yamaguchi M, Hisamatsu Y, Umehara T, Higuchi T
RSC Advances   8(64) 36895-36902   Oct 2018   [Refereed]
Tsusaka T, Kikuchi M, Shimazu T, Suzuki T, Sohtome Y, Akakabe M, Sodeoka M, Dohmae N, Umehara T, Shinkai Y
Epigenetics & Chromatin   11(1) 56   Oct 2018   [Refereed]
Handoko L, Kaczkowski B, Hon CC, Lizio M, Wakamori M, Matsuda T, Ito T, Jeyamohan P, Sato Y, Sakamoto K, Yokoyama S, Kimura H, Minoda A, Umehara T
Epigenetics   13(4) 410-431   Aug 2018   [Refereed]
Hirano T, Fujiwara T, Niwa H, Hirano M, Ohira K, Okazaki Y, Sato S, Umehara T, Maemoto Y, Ito A, Yoshida M, Kagechika H
ChemMedChem   13(15) 1530-1540   Jun 2018   [Refereed]
Niwa H, Sato S, Hashimoto T, Matsuno K, Umehara T
Molecules   23(7) 1538   Jun 2018   [Refereed]
Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI
eLife   7 32893   Apr 2018   [Refereed]
Osada N, Kikuchi J, Umehara T, Sato S, Urabe M, Abe T, Hayashi N, Sugitani M, Hanazono Y, Furukawa Y
Oncotarget   9(5) 6450-6462   Jan 2018   [Refereed]
Shinohara Y, Koyama YM, Ukai-Tadenuma M, Hirokawa T, Kikuchi M, Yamada RG, Ukai H, Fujishima H, Umehara T, Tainaka K, Ueda HR
Molecular Cell   67(5) 783-798   Sep 2017   [Refereed]
Niwa H, Umehara T
Epigenetics   12(5) 340-352   May 2017   [Refereed]
Amano Y, Kikuchi M, Sato S, Yokoyama S, Umehara T, Umezawa N, Higuchi T
Bioorganic & Medicinal Chemistry   25(9) 2617-2624   May 2017   [Refereed]
Ehara H, Umehara T, Sekine SI, Yokoyama S
Biochemical and Biophysical Research Communications   487(2) 230-235   May 2017   [Refereed]
Nagano-Shoji M, Hamamoto Y, Mizuno Y, Yamada A, Kikuchi M, Shirouzu M, Umehara T, Yoshida M, Nishiyama M, Kosono S
Molecular Microbiology   104(4) 677-689   Mar 2017   [Refereed]
Amano Y, Umezawa N, Sato S, Watanabe H, Umehara T, Higuchi T
Bioorganic & Medicinal Chemistry   25(3) 1227-1234   Jan 2017   [Refereed]
Fujii Y, Wakamori M, Umehara T, Yokoyama S
FEBS Open Bio   6(6) 498-514   May 2016   [Refereed]
Takemoto Y, Ito A, Niwa H, Okamura M, Fujiwara T, Hirano T, Handa N, Umehara T, Sonoda T, Ogawa K, Tariq M, Nishino N, Dan S, Kagechika H, Yamori T, Yokoyama S, Yoshida M
Journal of Medicinal Chemistry   59(8) 3650-3660   Apr 2016   [Refereed]
Kaimori JY, Maehara K, Hayashi-Takanaka Y, Harada A, Fukuda M, Yamamoto S, Ichimaru N, Umehara T, Yokoyama S, Matsuda R, Ikura T, Nagao K, Obuse C, Nozaki N, Takahara S, Takao T, Ohkawa Y, Kimura H, Isaka Y
Scientific Reports   6 24318   Apr 2016   [Refereed]
Kashiwagi K, Takahashi M, Nishimoto M, Hiyama TB, Higo T, Umehara T, Sakamoto K, Ito T, Yokoyama S
Nature   531(7592) 122-125   Feb 2016   [Refereed]
Wakamori M, Fujii Y, Suka N, Shirouzu M, Sakamoto K, Umehara T, Yokoyama S
Scientific Reports   5 17204   Nov 2015   [Refereed]
Hayashi-Takanaka Y, Maehara K, Harada A, Umehara T, Yokoyama S, Obuse C, Ohkawa Y, Nozaki N, Kimura H
Chromosome Research   23(4) 753-766   Sep 2015   [Refereed]
Tochio N, Umehara T, Nakabayashi K, Yoneyama M, Tsuda K, Shirouzu M, Koshiba S, Watanabe S, Kigawa T, Sasazuki T, Shirasawa S, Yokoyama S
Journal of Structural and Functional Genomics   16(2) 55-65   Jun 2015   [Refereed]
Nagaoka K, Hino S, Sakamoto A, Anan K, Takase R, Umehara T, Yokoyama S, Sasaki Y, Nakao M
Molecular and Cellular Biology   35(7) 1068-1080   Apr 2015   [Refereed]
Higo T, Suka N, Ehara H, Wakamori M, Sato S, Maeda H, Sekine SI, Umehara T, Yokoyama S
Journal of Structural and Functional Genomics   15(4) 191-199   Dec 2014   [Refereed]
Yanagisawa T, Umehara T, Sakamoto K, Yokoyama S
Chembiochem   15(15) 2181-2187   Oct 2014   [Refereed]
Yanagisawa T, Takahashi M, Mukai T, Sato S, Wakamori M, Shirouzu M, Sakamoto K, Umehara T, Yokoyama S
Chembiochem   15(12) 1830-1838   Aug 2014   [Refereed]
Niwa H, Handa N, Tomabechi Y, Honda K, Toyama M, Ohsawa N, Shirouzu M, Kagechika H, Hirano T, Umehara T, Yokoyama S
Acta Crystallographica Section D   69(4) 595-602   Apr 2013   [Refereed]
Umehara T, Shirouzu M, Yokoyama S
Current Medical Imaging Reviews   8(4) 308-313   Nov 2012   [Refereed]
Wakamori M, Umehara T, Yokoyama S
Analytical Biochemistry   423(1) 184-186   Apr 2012   [Refereed]
Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, Umehara T, Yokoyama S, Kosai K, Nakao M
Nature Communications   3 758   Mar 2012   [Refereed]
Mukai T, Yanagisawa T, Ohtake K, Wakamori M, Adachi J, Hino N, Sato A, Kobayashi T, Hayashi A, Shirouzu M, Umehara T, Yokoyama S, Sakamoto K
Biochemical and Biophysical Research Communications   411(4) 757-761   Aug 2011   [Refereed]
Ito T, Umehara T, Sasaki K, Nakamura Y, Nishino N, Terada T, Shirouzu M, Padmanabhan B, Yokoyama S, Ito A, Yoshida M
Chemistry & Biology   18(4) 495-507   Apr 2011   [Refereed]
Sato S, Mimasu S, Sato A, Hino N, Sakamoto K, Umehara T, Yokoyama S
Biochemistry   50(2) 250-257   Jan 2011   [Refereed]
Morishita D, Takami M, Yoshikawa S, Katayama R, Sato S, Kukimoto-Niino M, Umehara T, Shirouzu M, Sekimizu K, Yokoyama S, Fujita N
Journal of Biological Chemistry   286(4) 2681-2688   Jan 2011   [Refereed]
Wakamori M, Umehara T, Yokoyama S
Protein Expression and Purification   74(1) 88-98   Nov 2010   [Refereed]
Umehara T, Nakamura Y, Wakamori M, Ozato K, Yokoyama S, Padmanabhan B
FEBS Letters   584(18) 3901-3908   Sep 2010   [Refereed]
He F, Umehara T, Saito K, Harada T, Watanabe S, Yabuki T, Kigawa T, Takahashi M, Kuwasako K, Tsuda K, Matsuda T, Aoki M, Seki E, Kobayashi N, Güntert P, Yokoyama S, Muto Y
Structure   18(9) 1127-1139   Sep 2010   [Refereed]
Tochio N, Umehara T, Munemasa Y, Suzuki T, Sato S, Tsuda K, Koshiba S, Kigawa T, Nagai R, Yokoyama S
Journal of Molecular Biology   401(1) 97-114   Aug 2010   [Refereed]
Mimasu S, Umezawa N, Sato S, Higuchi T, Umehara T, Yokoyama S
Biochemistry   49(30) 6494-6503   Aug 2010   [Refereed]
Umehara T, Nakamura Y, Jang MK, Nakano K, Tanaka A, Ozato K, Padmanabhan B, Yokoyama S
Journal of Biological Chemistry   285(10) 7610-7618   Mar 2010   [Refereed]
Shimada A, Takano K, Shirouzu M, Hanawa-Suetsugu K, Terada T, Toyooka K, Umehara T, Yamamoto M, Yokoyama S, Suetsugu S
FEBS Letters   584(6) 1111-1118   Mar 2010   [Refereed]
Kumarevel T, Tanaka T, Umehara T, Yokoyama S
Nucleic Acids Research   37(14) 4723-4735   Aug 2009   [Refereed]
Lin YJ, Umehara T, Inoue M, Saito K, Kigawa T, Jang MK, Ozato K, Yokoyama S, Padmanabhan B, Güntert P
Protein Science   17(12) 2174-2179   Dec 2008   [Refereed]
Malay AD, Umehara T, Matsubara-Malay K, Padmanabhan B, Yokoyama S
Journal of Biological Chemistry   283(20) 14022-14031   May 2008   [Refereed]
Mimasu S, Sengoku T, Fukuzawa S, Umehara T, Yokoyama S
Biochemical and Biophysical Research Communications   366(1) 15-22   Feb 2008   [Refereed]
Nakamura Y, Umehara T, Tanaka A, Horikoshi M, Padmanabhan B, Yokoyama S
Biochemical and Biophysical Research Communications   359(3) 503-509   Aug 2007   [Refereed]
He F, Umehara T, Tsuda K, Inoue M, Kigawa T, Matsuda T, Yabuki T, Aoki M, Seki E, Terada T, Shirouzu M, Tanaka A, Sugano S, Muto Y, Yokoyama S
Protein Science   16(8) 1577-1587   Aug 2007   [Refereed]
Umehara T, Wakamori M, Tanaka A, Padmanabhan B, Yokoyama S
Acta Crystallographica Section F   63(7) 613-615   Jul 2007   [Refereed]
Nakamura Y, Umehara T, Hamana H, Hayashizaki Y, Inoue M, Kigawa T, Shirouzu M, Terada T, Tanaka A, Padmanabhan B, Yokoyama S
Journal of Molecular Biology   370(1) 80-92   Jun 2007   [Refereed]
Yoneyama M, Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Watanabe S, Tomo Y, Nishimura Y, Harada T, Terada T, Shirouzu M, Hayashizaki Y, Ohara O, Tanaka A, Kigawa T, Yokoyama S
Journal of Molecular Biology   369(1) 222-238   May 2007   [Refereed]
Nakamura Y, Umehara T, Tanaka A, Horikoshi M, Padmanabhan B, Yokoyama S
Acta Crystallographica Section F   63(3) 190-192   Mar 2007   [Refereed]
Nakamura Y, Umehara T, Nakano K, Jang MK, Shirouzu M, Morita S, Uda-Tochio H, Hamana H, Terada T, Adachi N, Matsumoto T, Tanaka A, Horikoshi M, Ozato K, Padmanabhan B, Yokoyama S
Journal of Biological Chemistry   282(6) 4193-4201   Feb 2007   [Refereed]
Tanaka H, Umehara T, Inaka K, Takahashi S, Shibata R, Bessho Y, Sato M, Sugiyama S, Fusatomi E, Terada T, Shirouzu M, Sano S, Motohara M, Kobayashi T, Tanaka T, Tanaka A, Yokoyama S
Acta Crystallographica Section F   63(2) 69-73   Feb 2007   [Refereed]
Nakamura Y, Nakano K, Umehara T, Kimura M, Hayashizaki Y, Tanaka A, Horikoshi M, Padmanabhan B, Yokoyama S
Structure   15(2) 179-189   Feb 2007   [Refereed]
Matsubara K, Sano N, Umehara T, Horikoshi M
Genes to Cells   12(1) 13-33   Jan 2007   [Refereed]
Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Watanabe S, Tomo Y, Hanada M, Ikari M, Sato M, Terada T, Nagase T, Ohara O, Shirouzu M, Tanaka A, Kigawa T, Yokoyama S
Structure   14(3) 457-468   Mar 2006   [Refereed]
Padmanabhan B, Kataoka K, Umehara T, Adachi N, Yokoyama S, Horikoshi M
Journal of Biochemistry   138(6) 821-829   Dec 2005   [Refereed]
Umehara T, Otta Y, Tsuganezawa K, Matsumoto T, Tanaka A, Horikoshi M, Padmanabhan B, Yokoyama S
Acta Crystallographica Section F   61(11) 971-973   Nov 2005   [Refereed]
Oishi K, Miyazaki K, Kadota K, Kikuno R, Nagase T, Atsumi G, Ohkura N, Azama T, Mesaki M, Yukimasa S, Kobayashi H, Iitaka C, Umehara T, Horikoshi M, Kudo T, Shimizu Y, Yano M, Monden M, Machida K, Matsuda J, Horie S, Todo T, Ishida N
Journal of Biological Chemistry   278(42) 41519-41527   Oct 2003   [Refereed]
Umehara T, Horikoshi M
Journal of Biological Chemistry   278(37) 35660-35667   Sep 2003   [Refereed]
Kimura A, Umehara T, Horikoshi M
Nature Genetics   32(3) 370-377   Nov 2002   [Refereed]
Umehara T, Chimura T, Ichikawa N, Horikoshi M
Genes to Cells   7(1) 59-73   Jan 2002   [Refereed]
Yamaki M, Umehara T, Chimura T, Horikoshi M
Genes to Cells   6(12) 1043-1054   Dec 2001   [Refereed]
Umehara T, Kida S, Hasegawa S, Fujimoto H, Horikoshi M
Journal of Biochemistry   121(3) 598-603   Mar 1997   [Refereed]
Umehara T, Kida S, Yamamoto T, Horikoshi M
Gene   167(1-2) 297-302   Dec 1995   [Refereed]
Kida S, Umehara T, Horikoshi M
Gene   161(2) 303-304   Sep 1995   [Refereed]
Umehara T, Kida S, Horikoshi M
Gene   161(2) 301-302   Aug 1995   [Refereed]

Books etc

 
Academic drug discovery by platforms of structure analysis and in silico design
Mikako Shirouzu, Teruki Honma, Takashi Umehara
J. Clin. Exp. Med. 254(8) 566-570   2015   
New frontiers of epigenetics researches in pharmaceutical sciences
Takashi Umehara, Yuichiro Hori
J. Pharm. Soc. Jpn. 135(1) 1-2   2015   
Analysis of gene expression regulation through precise reconstitution of ‘epi-nucleosome’
Takashi Umehara
Seitai No Kagaku (Igaku Shoin Ltd.) 65(5) 462-463   2014   
Epigenetics-targeted drug development
Takashi Umehara
SAR Newsletter (Pharmaceutical Society of Japan) No. 25, pp. 9-16   2013   
Molecular structures of Krüppel-like factors
Toshio Nagashima, Fumiaki Hayashi, Takashi Umehara, Shigeyuki Yokoyama
The Biology of Krüppel-like Factors (Springer) pp. 21-31   2009   
Crystal structure analysis for in silico drug development
Takashi Umehara, Shigeyuki Yokoyama
Idenshi Igaku Mook (Medical Do Ltd.) pp. 28-33   2009   
SWIRM, a newly identified domain involved in the regulation of chromatin
Takashi Umehara
Gene Engineering (Yodosha Ltd.) pp.134-135   2006   
New theory on gene regulation: mechanism of formation of chromosome functional and boundary regions
Masami Horikoshi, Toru Yamamoto, Takashi Umehara, Toru Suzuki, Naruhiko Adachi, Akatsuki Kimura
Protein, Nucleic Acid and Enzyme 48(3) 205-222   2003   
Understanding of regulatory mechanisms of RNA polymerase III transcription
Takashi Umehara, Masami Horikoshi
Gene Expression (Chugai Med. Ltd.) pp.187-203   2001   
Arolla workshop 1997: expression, maintenance and propagation of the genome
Takashi Umehara, Masaki Bando, Masami Horikoshi
Protein, Nucleic Acid and Enzyme 43(3) 287-290   1998   

Research Grants & Projects

 
Japan Society for the Promotion of Science (JSPS): Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2020    Investigator(s): Takashi Umehara
Japan Science and Technology Agency (JST): Precursory Research for Embryonic Science and Technology (PRESTO) program
Project Year: Oct 2012 - Mar 2016    Investigator(s): Takashi Umehara
Japan Society for the Promotion of Science (JSPS): Grant-in-Aid for Scientific Research
Project Year: Apr 2012 - Mar 2015    Investigator(s): Takashi Umehara
Ministry of Education, Culture, Sports, Science and Technology (MEXT): Grant-in-Aid for Scientific Research
Project Year: Apr 2010 - Mar 2012    Investigator(s): Takashi Umehara
National Institute of Biomedical Innovation (NIBIO): Grant-in-Aid of the Program for Promotion of Fundamental Studies in Health Sciences
Project Year: Aug 2008 - Mar 2011    Investigator(s): Takashi Umehara
Ministry of Education, Culture, Sports, Science and Technology (MEXT): Grant-in-Aid for Scientific Research
Project Year: Apr 2007 - Mar 2009    Investigator(s): Takashi Umehara