Yoshinobu Uno

Profile Information

Affiliation: 助教, 大学院総合文化研究科, 東京大学

Researcher number: 60609717
ORCID ID: https://orcid.org/0000-0001-9609-1186
J-GLOBAL ID: 201401094712641927
researchmap Member ID: B000236296

これまで両生類の初代培養細胞からFISHなどの染色体解析を行っており、2016年に発表されたアフリカツメガエルの全ゲノム解読に大きく貢献した実績をもつ（Session, Uno et al. 2016 Nature 538:336）。
現在では両生類だけでなく、無顎類から軟骨魚類、哺乳類に至る幅広い脊椎動物種を用いた染色体解析を展開している。また、上記のツメガエルゲノム解読にて大規模データの処理のためのバイオインフォマティクスの重要性と面白さを再認識し、軟骨魚類を対象動物とした次世代シーケンサーデータを用いたオミクス解析にも従事している。

Research Interests

Research Areas

Research History

Oct, 2020 - Present

Assistant Professor, Graduate School of Arts and Sciences, The University of Tokyo
Oct, 2017 - Sep, 2020

研究員, 生命機能科学研究センター, 国立研究開発法人理化学研究所
Apr, 2011 - Sep, 2017

Graduate School of Bioagricultural Sciences, Nagoya University

Education

Apr, 2006 - Mar, 2011

Division of Life Sciences, Graduate School of Life Science, Hokkaido University
Apr, 2002 - Mar, 2006

Biological Sciences, School of Science, Hokkaido University

Awards

Sep, 2019

SCR Prize, Studies on genomic and chromosomal evolution in amphibians, The Society of Chromosome Research

Yoshinobu Uno

Major Papers

Diversity and Evolution of Highly Repetitive DNA Sequences Constituting Chromosome Site-Specific Heterochromatin in Two Gerbillinae Species

Yoshinobu Uno, Kazumi Matsubara, Jun Inoue, Johji Inazawa, Akio Shinohara, Chihiro Koshimoto, Kenji Ichiyanagi, Yoichi Matsuda

Cytogenetic and Genome Research, 1-10, Sep 14, 2023
Molecular Cytogenetic Characterization of C-Band-Positive Heterochromatin of the Greater Long-Tailed Hamster (Tscherskia triton, Cricetinae)

Eikichi Kamimura, Yoshinobu Uno, Kazuhiko Yamada, Chizuko Nishida, Yoichi Matsuda

Cytogenetic and Genome Research, 162(6) 323-333, Dec 19, 2022
Inference of evolution of vertebrate genomes and chromosomes from genomic and cytogenetic analyses using amphibians

Yoshinobu Uno

2021 Peer-reviewedCorresponding author
Cell culture-based karyotyping of orectolobiform sharks for chromosome-scale genome analysis.

Yoshinobu Uno, Ryo Nozu, Itsuki Kiyatake, Nobuyuki Higashiguchi, Shuji Sodeyama, Kiyomi Murakumo, Keiichi Sato, Shigehiro Kuraku

Communications biology, 3(1) 652-652, Nov 6, 2020 Peer-reviewedLead authorCorresponding author
Molecular cytogenetic characterization of repetitive sequences comprising centromeric heterochromatin in three Anseriformes species.

Uno Y, Nishida C, Hata A, Ishishita S, Matsuda Y

PloS one, 14(3) e0214028-e0214028, 2019 Peer-reviewedLead authorCorresponding author
Genome evolution in the allotetraploid frog Xenopus laevis.

Session Adam M, Uno Yoshinobu, Kwon Taejoon, Chapman Jarrod A, Toyoda Atsushi, Takahashi Shuji, Fukui Akimasa, Hikosaka Akira, Suzuki Atsushi, Kondo Mariko …

Nature, 538(7625) 336-343, 2016 Peer-reviewedLead author
Homoeologous chromosomes of Xenopus laevis are highly conserved after whole-genome duplication

Y. Uno, C. Nishida, C. Takagi, N. Ueno, Y. Matsuda

Heredity, 111(5) 430-436, Nov, 2013 Peer-reviewedLead author

Misc.

Xenopus laevis全ゲノム解析アフリカツメガエルnodal5とnodal6遺伝子クラスターについての解析

高橋秀治, 豊田敦, 宇野好宣, 黒木陽子, 彦坂暁, 原本悦和, 田中利明, 西城智仁, 野口英樹, 松田洋一 …

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [1P0565]-[1P0565], Dec, 2015
Xenopus laevis全ゲノム解析:モデル両生類のゲノム進化におけるTGF-betaシグナル伝達経路のユニークな変化とその生物学的意義

鈴木厚, 高橋秀治, 宇野好宣, 回渕修治, GRIMWOOD Jane, 松田洋一, 伊藤道彦, ROKHSAR Daniel, 平良眞規

日本生化学会大会(Web), 88th, 2015

Professional Memberships

Research Projects

Elucidation of evolutionary significance of vertebrate microchromosomes conserved for 400 million years

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Investigation of the origins of microchromosomes from chromosomes of lungfish, shark, and hagfish

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020
Process of genomic and chromosomal evolution in vertebrates inferred from comparative gene mapping for archaic-looking fishes

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Uno Yoshinobu
Investigation of the evolutionary process of genome and chromosomes using lungfish

Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (A)), Fund for the Promotion of Joint International Research (Fostering Joint International Research (A)), Japan Society for the Promotion of Science, 2018 - 2018
Genomic and chromosomal evolution of vertebrates inferred from comparative gene mapping

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

UNO Yoshinobu
エゾサンショウウオにおける温度依存的な性決定・性分化機構の解析

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2009 - 2010

宇野好宣

Media Coverage

東大など、アフリカツメガエルのゲノムを解読 - 「全ゲノム重複」解明の鍵