浦野泰臣 (Yasuomi Urano) - マイポータル

基本情報

所属: 同志社大学生命医科学部医生命システム学科准教授

学位: 博士（工学）(東京大学)
修士（薬学）(千葉大学)

研究者番号: 00546674
ORCID ID: https://orcid.org/0000-0002-4901-1937
J-GLOBAL ID: 201301068714571138
researchmap会員ID: B000233827

研究キーワード

研究分野

ライフサイエンス / 細胞生物学 /

経歴

2018年 - 現在

同志社大学生命医科学部准教授
2009年 - 2018年

同志社大学生命医科学部助教
2005年 - 2009年

Dartmouth Medical School Research Associate
2004年 - 2005年

東京大学先端科学技術研究センター特任研究員

学歴

論文

Enzymatically Formed Oxysterols and Cell Death.

Yasuomi Urano, Noriko Noguchi

Advances in experimental medicine and biology 1440 193-211 2024年査読有り筆頭著者責任著者
α-Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of endoplasmic reticulum membrane disruption.

Ren Chiba, Yasuomi Urano, Noriko Noguchi

Steroids 189 109136-109136 2023年1月査読有り責任著者
Suppression of Amyloid-β Adsorption on Endoplasmic Reticulum Stress-Mimicking Membranes by α-Tocopherol and α-Tocotrienol

Yusuke Nakatani, Naofumi Shimokawa, Yasuomi Urano, Noriko Noguchi, Masahiro Takagi

The Journal of Physical Chemistry Letters 11955-11960 2022年12月19日査読有り
Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism

Yasuomi Urano, Shoya Osaki, Ren Chiba, Noriko Noguchi

Cell Death Discovery 2022年10月4日査読有り筆頭著者責任著者
Redox-sensitive DJ-1 protein: an insight into physiological roles, secretion, and therapeutic target

Biplab Kumar Dash, Yasuomi Urano, Yoshiro Saito, Noriko Noguchi

Redox Experimental Medicine 2022年7月1日査読有り
Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis.

Hajime Kato, Hiroyasu Sato, Michiaki Okuda, Jun Wu, Shingo Koyama, Yasuhiko Izumi, Tomonori Waku, Mitsuyoshi Iino, Masashi Aoki, Shigeki Arawaka …

Amyotrophic lateral sclerosis & frontotemporal degeneration 23(7-8) 1-7 2021年12月11日査読有り
NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition.

Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi …

iScience 24(10) 103180-103180 2021年10月22日査読有り
Different functions of vitamin E homologues in the various types of cell death induced by oxysterols.

Atsuki Suzuki, Yasuomi Urano, Tomohisa Ishida, Noriko Noguchi

Free radical biology & medicine 176 356-365 2021年10月12日査読有り
Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation.

Yuichiro Mita, Risa Uchida, Sayuri Yasuhara, Kohei Kishi, Takayuki Hoshi, Yoshitaka Matsuo, Tadashi Yokooji, Yoshino Shirakawa, Takashi Toyama, Yasuomi Urano …

Nucleic acids research 49(12) 6893-6907 2021年7月9日査読有り
Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis.

Miku Kazama, Yoichiro Kato, Akiyoshi Kakita, Noriko Noguchi, Yasuomi Urano, Kenta Masui, Motoko Niida-Kawaguchi, Tomoko Yamamoto, Kazuhiko Watabe, Kazuo Kitagawa …

Neuropathology : official journal of the Japanese Society of Neuropathology 40(6) 587-598 2020年12月査読有り
Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.

Yasuomi Urano, Mina Takahachi, Ryo Higashiura, Hitomi Fujiwara, Satoru Funamoto, So Imai, Eugene Futai, Michiaki Okuda, Hachiro Sugimoto, Noriko Noguchi

Cells 9(2) 2020年2月3日査読有り筆頭著者責任著者
Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.

Kimiyuki Shibuya, Shigeru Morikawa, Masayoshi Miyamoto, Shin-Ichiro Ogawa, Yoshihiko Tsunenari, Yasuomi Urano, Noriko Noguchi

ACS omega 4(16) 16943-16955 2019年10月15日査読有り
24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventional cell death

Urano, Y., Ho Vo, D.-K., Hirofumi, A., Noguchi, N.

Cell Death Discovery 5(1) 113 2019年査読有り筆頭著者責任著者
Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.

Kimura Y, Asa M, Urano Y, Saito Y, Nishikawa K, Noguchi N

Biochimie 153 203-209 2018年10月査読有り
6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway

Urano, Y., Mori, C., Fuji, A., Konno, K., Yamamoto, T., Yashirogi, S., Ando, M., Saito, Y., Noguchi, N.

Autophagy 14(11) 1-16 2018年8月査読有り筆頭著者責任著者
Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis

Takaya Nakazawa, Yuta Miyanoki, Yasuomi Urano, Madoka Uehara, Yoshiro Saito, Noriko Noguchi

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 169 69-76 2017年5月査読有り
Decrease of Amyloid-β Levels by Curcumin Derivative via Modulation of Amyloid-β Protein Precursor Trafficking.

Kotani R, Urano Y, Sugimoto H, Noguchi N

Journal of Alzheimer's disease : JAD 56(2) 529-542 2017年査読有り責任著者
Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death

Wakako Takabe, Yasuomi Urano, Diep-Khanh Ho Vo, Kimiyuki Shibuya, Masaki Tanno, Hiroaki Kitagishi, Toyoshi Fujimoto, Noriko Noguchi

JOURNAL OF LIPID RESEARCH 57(11) 2005-2014 2016年11月査読有り責任著者
Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death

Kimiyuki Shibuya, Toshiaki Watanabe, Yasuomi Urano, Wakako Takabe, Noriko Noguchi, Hiroaki Kitagishi

BIOORGANIC & MEDICINAL CHEMISTRY 24(11) 2559-2566 2016年6月査読有り
Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells

Mayuko Morita, Azusa Sekine, Yasuomi Urano, Taki Nishimura, Wakako Takabe, Hiroyuki Arai, Takao Hamakubo, Tatsuhiko Kodama, Noriko Noguchi

JOURNAL OF BIOCHEMISTRY 158(4) 331-338 2015年10月査読有り