論文

査読有り
2015年10月

New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death

FREE RADICAL BIOLOGY AND MEDICINE
  • Noriko Noguchi
  • ,
  • Yasuomi Urano
  • ,
  • Wakako Takabe
  • ,
  • Yoshiro Saito

87
開始ページ
366
終了ページ
372
記述言語
英語
掲載種別
DOI
10.1016/j.freeradbiomed.2015.06.036
出版者・発行元
ELSEVIER SCIENCE INC

24(5)-Hydroxycholesterol (24S-OHC), which is enzymatically produced in the brain, has been known to play an important role in maintaining cholesterol homeostasis in the brain and has been proposed as a possible biomarker of neurodegenerative disease. Recent studies have revealed diverse functions of 24SOHC and gained increased attention. For example, 24S-OHC at sublethal concentrations has been found to induce an adaptive response via activation of the liver X receptor signaling pathway, thereby protecting neuronal cells against subsequent oxidative stress. It has also been found that physiological concentrations of 24S-OHC suppress amyloid-beta production via downregulation of amyloid precursor protein trafficking in neuronal cells. On the other hand, high concentrations of 24S-OHC have been found to induce a type of nonapoptotic programmed cell death in neuronal cells expressing little caspase-8. Because neuronal cell death induced by 24S-OHC has been found to proceed by a unique mechanism, which is different from but in some ways similar to necroptosis necroptosis being a type of programmed necrosis induced by tumor necrosis factor alpha neuronal cell death induced by 24S-OHC has been called "necroptosis-like" cell death. 24S-OHC-induced cell death is dependent on the formation of 24S-OHC esters but not on oxidative stress. This review article discusses newly reported aspects of 24S-OHC in neuronal cell death and sheds light on the possible importance of controlling 24S-OHC levels in the brain for preventing neuroclegenerative disease. (C) 2015 Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.freeradbiomed.2015.06.036
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26164631
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000363277100032&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.freeradbiomed.2015.06.036
  • ISSN : 0891-5849
  • eISSN : 1873-4596
  • PubMed ID : 26164631
  • Web of Science ID : WOS:000363277100032

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