論文

国際誌
2022年1月6日

Free radical scavenging activities of verbascoside and isoverbascoside from the leaves of Odontonema strictum (Acanthaceae).

Bioorganic & medicinal chemistry letters
  • Lokadi Pierre Luhata
  • ,
  • Toyonobu Usuki

開始ページ
128528
終了ページ
128528
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bmcl.2022.128528

The aqueous extract of the leaves of Odontonema strictum, a plant from tropical regions, is used by traditional physicians in Burkina Faso for its antihypertensive properties. Verbascoside and isoverbascoside, known phenylpropanoid glycosides with high solubility in water, have been isolated from the leaves. We evaluated their antioxidant properties in vitro by radical scavenging using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2). Verbascoside and isoverbascoside demonstrated high levels of DPPH radical scavenging activity, with IC50 values of 0.09±0.03 μg/mL and 0.16±0.07 μg/mL, respectively, compared to 0.05±0.0 μg/mL for ascorbic acid as a control. These two phenylpropanoid glycosides were also more potent (2.6±0.36 μg/mL and 3.0±0.01 μg/mL) in scavenging H2O2 than the ascorbic acid control (4.1±0.97 µg/mL). This is the first time that the antioxidant properties of verbascoside and isoverbascoside from O. strictum have been evaluated. These results can explain the use of this plant for hypertension in folk medicine.

リンク情報
DOI
https://doi.org/10.1016/j.bmcl.2022.128528
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34999211
ID情報
  • DOI : 10.1016/j.bmcl.2022.128528
  • PubMed ID : 34999211

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