論文

国際誌
2024年2月1日

The prognostic values of plasma desmosines, crosslinking molecules of elastic fibers, in the disease progression of Moyamoya disease.

Bioorganic & medicinal chemistry
  • Ryosuke Tashiro
  • Riki Anzawa
  • Tomoo Inoue
  • Ayame Mikagi
  • Dan Ozaki
  • Keita Tominaga
  • Takashi Inoue
  • Tomohisa Ishida
  • Miki Fujimura
  • Toyonobu Usuki
  • Hidenori Endo
  • Kuniyasu Niizuma
  • Teiji Tominaga
  • 全て表示

100
開始ページ
117602
終了ページ
117602
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bmc.2024.117602

Moyamoya disease (MMD) is a cerebrovascular disease which is characterized by the chronic progression of steno-occlusive changes at the terminal portion of internal carotid arteries and the development of "moyamoya vessels." Dysregulation of the extracellular matrix is regarded as a key pathophysiology underlying unique vascular remodeling. Here, we measured the concentration of elastin crosslinkers desmosine and isodesmosine in the plasma of MMD patients. We aimed to reveal its diagnostic values of desmosines in the progression of steno-occlusive lesions. The concentrations of plasma desmosines were determined by liquid chromatography-tandem mass spectrometry. The temporal profiles of steno-occlusive lesions on magnetic resonance angiography were retrospectively evaluated, and the correlation between the progression of steno-occlusive changes in intracranial arteries and plasma desmosines concentrations was further analyzed. Plasma desmosines were significantly higher in MMD patients with disease progression compared to MMD patients without disease progression. Also, the incidence of disease progression was higher in MMD patients with plasma desmosines levels over limit of quantitation (LOQ) than those with plasma desmosines levels below LOQ. In conclusion, plasma desmosines could be potential biomarkers to predict the progression of steno-occlusive changes in MMD patients.

リンク情報
DOI
https://doi.org/10.1016/j.bmc.2024.117602
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/38324946
ID情報
  • DOI : 10.1016/j.bmc.2024.117602
  • PubMed ID : 38324946

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