2018年7月
Post-injury stretch promotes recovery in a rat model of muscle damage induced by lengthening contractions.
The journal of physiological sciences : JPS
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- 巻
- 68
- 号
- 4
- 開始ページ
- 483
- 終了ページ
- 492
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12576-017-0553-9
- 出版者・発行元
- SPRINGER JAPAN KK
We investigated the cellular mechanisms and therapeutic effect of post-injury stretch on the recovery process from muscle injury induced by lengthening contractions (LC). One day after LC, a single 15-min bout of muscle stretch was applied at an intensity of 3 mNm. The maximal isometric torque was measured before and at 2-21 days after LC. The myofiber size was analyzed at 21 days after LC. Developmental myosin heavy chain-immunoreactive (dMHC-ir) cells, a marker of regenerating myofibers, were observed in the early recovery stage (2-5 days after LC). We observed that LC-induced injury markedly decreased isometric torque and myofiber size, which recovered faster in rats that underwent stretch than in rats that did not. Regenerating myofiber with dMHC-ir cells was observed earlier in rats that underwent stretch. These results indicate that post-injury stretch may facilitate the regeneration and early formation of new myofibers, thereby promoting structural and functional recovery from LC-induced muscle injury.
- リンク情報
- ID情報
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- DOI : 10.1007/s12576-017-0553-9
- ISSN : 1880-6546
- eISSN : 1880-6562
- PubMed ID : 28667588
- Web of Science ID : WOS:000434180700016