2017年2月
Training at non-damaging intensities facilitates recovery from muscle atrophy.
Muscle & nerve
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- 巻
- 55
- 号
- 2
- 開始ページ
- 243
- 終了ページ
- 253
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/mus.25218
- 出版者・発行元
- WILEY
INTRODUCTION: Resistance training promotes recovery from muscle atrophy, but optimum training programs have not been established. We aimed to determine the optimum training intensity for muscle atrophy. METHODS: Mice recovering from atrophied muscles after 2 weeks of tail suspension underwent repeated isometric training with varying joint torques 50 times per day. RESULTS: Muscle recovery assessed by maximal isometric contraction and myofiber cross-sectional areas (CSAs) were facilitated at 40% and 60% maximum contraction strength (MC), but at not at 10% and 90% MC. At 60% and 90% MC, damaged and contained smaller diameter fibers were observed. Activation of myogenic satellite cells and a marked increase in myonuclei were observed at 40%, 60%, and 90% MC. CONCLUSIONS: The increases in myofiber CSAs were likely caused by increased myonuclei formed through fusion of resistance-induced myofibers with myogenic satellite cells. These data indicate that resistance training without muscle damage facilitates efficient recovery from atrophy. Muscle Nerve 55: 243-253, 2017.
- リンク情報
- ID情報
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- DOI : 10.1002/mus.25218
- ISSN : 0148-639X
- eISSN : 1097-4598
- PubMed ID : 27301985
- Web of Science ID : WOS:000395424700016