Uyeda Akiko - My portal

Profile Information

Affiliation: National Institute of Neuroscience,Ncnp, National Center of Neurology and Psychiatry

Degree: 博士(理学)(大阪大学)

J-GLOBAL ID: 201901017811616260
researchmap Member ID: B000356279

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Research History

Apr, 2023 - Present

薬理作用研究室長, 神経研究所神経薬理研究部, 国立研究開発法人国立精神・神経医療研究センター
Apr, 2020 - Mar, 2023

Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry
Apr, 2019 - Mar, 2020

Research Fellow, Department of Molecular Pharmacology, National Center of Neurology and Psychiatry

Education

Apr, 2014 - Mar, 2019

Graduate School of Frontier Biosciences, Osaka University
Apr, 2010 - Mar, 2014

Division of Biological Engineering, Department of Systems Science, School of Engineering Science, Osaka University

Awards

Sep, 2018

Cold Spring Harbor Poster Fellowship, Cold Spring Harbor Asia Meeting on "Latest Advances in Development & Function of Neuronal Circuits"

Uyeda Akiko

Papers

Microglia regulate central nervous system myelin growth and integrity.

Niamh B McNamara, David A D Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F J Bogie, Alana Hoffmann, Rebecca K Holloway, Irene Molina-Gonzalez, Katharine E Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W McColl, Marco Prinz, Tara L Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J A Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E Miron

Nature, 613(7942) 120-129, Jan, 2023 Peer-reviewed
Phenotypic and transcriptional characterization of oligodendrocyte precursor cells in a 3D culture

Shizuka Nakano, Akiko Uyeda, Yukiko T. Matsunaga, Rieko Muramatsu

Biomaterials Science, 2023 Peer-reviewed
LPA2 promotes neuronal differentiation and neurite formation in neocortical development.

Mizuki Uenaka, Akiko Uyeda, Tsutomu Nakahara, Rieko Muramatsu

Biochemical and biophysical research communications, 598 89-94, Apr 2, 2022 Peer-reviewedLead author
Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination.

Akiko Uyeda, Lili Quan, Yuki Kato, Nagaaki Muramatsu, Shogo Tanabe, Kazuhisa Sakai, Noritaka Ichinohe, Yukio Kawahara, Tatsunori Suzuki, Rieko Muramatsu

Glia, 69(11) 2591-2604, Jul 16, 2021 Peer-reviewedLead author
Age-dependent decline in remyelination capacity is mediated by apelin–APJ signaling

Masumi Ito, Rieko Muramatsu, Yuki Kato, Bikram Sharma, Akiko Uyeda, Shogo Tanabe, Harutoshi Fujimura, Hiroyasu Kidoya, Nobuyuki Takakura, Yukio Kawahara, Masaki Takao, Hideki Mochizuki, Akiyoshi Fukamizu, Toshihide Yamashita

Nature Aging, 1(3) 284-294, Mar, 2021 Peer-reviewed
Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation is Required for Development of Hippocampal Pyramidal Neurons.

Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo

The Journal of neuroscience, 40(47) 9012-9027, Oct, 2020 Peer-reviewedLead author
Immunocytochemistry and fluorescence imaging efficiently identify individual neurons with CRISPR/Cas9-mediated gene disruption in primary cortical cultures

Hiroto Tsunematsu, Akiko Uyeda, Nobuhiko Yamamoto, Noriyuki Sugo

BMC NEUROSCIENCE, 18(1) 55, Aug, 2017 Peer-reviewed
Genome Stability by DNA Polymerase beta in Neural Progenitors Contributes to Neuronal Differentiation in Cortical Development

Kohei Onishi, Akiko Uyeda, Mitsuhiro Shida, Teruyoshi Hirayama, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo

JOURNAL OF NEUROSCIENCE, 37(35) 8444-8458, Aug, 2017 Peer-reviewed

Misc.

Central nervous system regeneration: the roles of glial cells in the potential molecular mechanism underlying remyelination.

Lili Quan, Akiko Uyeda, Rieko Muramatsu

Inflammation and regeneration, 42(1) 7-7, Mar 2, 2022 Peer-reviewed
Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review.

Akiko Uyeda, Rieko Muramatsu

International journal of molecular sciences, 21(21), Oct 30, 2020 Peer-reviewedLead author
Basic Neuroscience 生化学(分子生物学) 神経回路の修復メカニズム

植田尭子, 村松里衣子

Annual Review神経, 2020 45-50, Apr, 2020
生後発達過程の大脳皮質においてPolβ欠損神経細胞は2本鎖DNA切断を異常に蓄積させる

日本生化学会大会(Web), 88th 3P1312 (WEB ONLY), 2015

Presentations

Genome maintenance by Polβ is required for epigenetic regulation of neuronal differentiation in the hippocampus and cortex

Uyeda Akiko

The 12th Annual Meeting for Japanese Developmental Neuroscientists, Mar 16, 2019
DNA polymerase β is required for postnatal hippocampal development and function

Cold Spring Harbor Asia meeting on Latest Advance in Development & Function of Neuronal Circuit, Sep 26, 2018
Maintenance of genome stability by DNA polymerase β in necessary for postnatal development in cortical and hippocampal neurons

Uyeda Akiko

The 41st Annual meeting of the Japan Neuroscience Society, Jul 27, 2018
Genome stability by DNA polymerase β is required for epigenetic regulation of neuronal differentiation in the postnatal cortex and hippocampus

Uyeda Akiko

S&B International Education Program, Jun 22, 2018
Genome stability by DNA polymerase β is required for neuronal differentiation in the postnatal cortex

Uyeda Akiko

The 22nd biennial meeting of the International Society for Developmental Neuroscience, May 23, 2018
DNA polymerase β is required for active DNA demethylation in postnatal developmentof cortical neurons.

Uyeda Akiko

The 48th NIPS International Symposium, Oct 30, 2017
The role of DNA polymerase β in postnatal cortical neuron development.

Uyeda Akiko

The 40th Annual meeting of the Japan Neuroscience Society, Jul 22, 2017
Involvement of DNA polymerase β in postnatal development of cortical neurons.

Uyeda Akiko

The 39th Annual meeting of the Japan Neuroscience Society, Jul 20, 2016
Polβ deficiency increases DNA double-strand breaks in postnatal cortical neurons

Uyeda Akiko

BMB2015, Dec 3, 2015

Professional Memberships

Committee Memberships

Apr, 2017 - Mar, 2019

代表, 脳科学若手の会関西部会

Research Projects

血中エクソソームを基軸とした自閉症スペクトラム障害の病態理解

科学研究費助成事業若手研究, 日本学術振興会, Apr, 2021 - Mar, 2023

植田尭子
自閉症における臓器連関を介した病態制御機構の解明

科学研究費助成事業研究活動スタート支援, 日本学術振興会, Aug, 2019 - Mar, 2021

植田尭子