Kazuki Sasaki - My portal

Profile Information

Affiliation: Sasaki Foundation

Degree: 博士（医学）

J-GLOBAL ID: 202101011452406409
researchmap Member ID: R000031320

Research Areas

Life sciences / Medical biochemistry / peptidomics

Research History

Aug, 2018 - Present

Sasaki Foundation

Papers

Integrin α5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma.

Shingo Miyamoto, Yoshiko Nagano, Makoto Miyazaki, Yuko Nagamura, Kazuki Sasaki, Takeshi Kawamura, Kazuyoshi Yanagihara, Toshio Imai, Rieko Ohki, Masakazu Yashiro, Masato Tanaka, Ryuichi Sakai, Hideki Yamaguchi

Cancer letters, 526 335-345, Feb 1, 2022 Peer-reviewed
Proteomic and microbiota analyses of the oral cavity during psychological stress.

Durga Paudel, Yasuhiro Kuramitsu, Osamu Uehara, Tetsuro Morikawa, Koki Yoshida, Sarita Giri, Syed Taufiqul Islam, Takao Kitagawa, Tadashi Kondo, Kazuki Sasaki, Hirofumi Matsuoka, Hiroko Miura, Yoshihiro Abiko

PloS one, 17(5) e0268155, 2022 Peer-reviewed
PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification.

Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Masako Yuki, Kiyoko Fukami, Kazuyoshi Yanagihara, Kazuki Sasaki, Ryuichi Sakai, Hideki Yamaguchi

Oncogenesis, 10(3) 25-25, Mar 6, 2021 Peer-reviewed
Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion.

Satsuki Miyazaki, Fumi Tashiro, Takashi Tsuchiya, Kazuki Sasaki, Jun-Ichi Miyazaki

Scientific reports, 11(1) 477-477, Jan 12, 2021 Peer-reviewed
Capillary electrophoresis electrospray ionization-mass spectrometry for peptidomics-based processing site determination.

Takashi Tsuchiya, Aya Nakayama, Takeshi Kawamura, Kazuki Sasaki

Biochemical and biophysical research communications, 533(4) 872-878, Dec 17, 2020 Peer-reviewedCorresponding author
Isolation of Endogenous Peptides from Cultured Cell Conditioned Media for Mass Spectrometry.

Kazuki Sasaki, Takashi Tsuchiya, Tsukasa Osaki

Methods in molecular biology (Clifton, N.J.), 1719 51-58, 2018 Peer-reviewedInvitedLead authorCorresponding author
Endogenous peptide profile for elucidating biosynthetic processing of the ghrelin precursor.

Takashi Tsuchiya, Hiroshi Iwakura, Naoto Minamino, Kenji Kangawa, Kazuki Sasaki

Biochemical and biophysical research communications, 490(4) 1142-1146, Sep 2, 2017 Peer-reviewedCorresponding author
NERP-2 regulates gastric acid secretion and gastric emptying via the orexin pathway.

Cherl Namkoong, Koji Toshinai, T M Zaved Waise, Hideyuki Sakoda, Kazuki Sasaki, Yoichi Ueta, Min-Seon Kim, Naoto Minamino, Masamitsu Nakazato

Biochemical and biophysical research communications, 485(2) 409-413, Apr 1, 2017 Peer-reviewed
Characterization of Gonadotrope Secretoproteome Identifies Neurosecretory Protein VGF-derived Peptide Suppression of Follicle-stimulating Hormone Gene Expression.

Soon Gang Choi, Qian Wang, Jingjing Jia, Maria Chikina, Hanna Pincas, Georgia Dolios, Kazuki Sasaki, Rong Wang, Naoto Minamino, Stephen R J Salton, Stuart C Sealfon

The Journal of biological chemistry, 291(40) 21322-21334, Sep 30, 2016 Peer-reviewed
Peptidomics for Studying Limited Proteolysis.

Takashi Tsuchiya, Tsukasa Osaki, Naoto Minamino, Kazuki Sasaki

Journal of proteome research, 14(11) 4921-31, Nov 6, 2015 Peer-reviewedCorresponding author
Chronic effects of neuroendocrine regulatory peptide (NERP-1 and -2) on insulin secretion and gene expression in pancreatic β-cells.

Ji-Won Kim, Marie Rhee, Jae-Hyung Park, Hideki Yamaguchi, Kazuki Sasaki, Naoto Minamino, Masamitsu Nakazato, Dae-Kyu Song, Kun-Ho Yoon

Biochemical and biophysical research communications, 457(2) 148-53, Feb 6, 2015 Peer-reviewed
Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory.

Mio Nonaka, Ryang Kim, Hotaka Fukushima, Kazuki Sasaki, Kanzo Suzuki, Michiko Okamura, Yuichiro Ishii, Takashi Kawashima, Satoshi Kamijo, Sayaka Takemoto-Kimura, Hiroyuki Okuno, Satoshi Kida, Haruhiko Bito

Neuron, 84(1) 92-106, Oct 1, 2014 Peer-reviewed
Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association.

Arata Tomiyama, Takamasa Uekita, Reiko Kamata, Kazuki Sasaki, Junko Takita, Miki Ohira, Akira Nakagawara, Chifumi Kitanaka, Kentaro Mori, Hideki Yamaguchi, Ryuichi Sakai

Cancer research, 74(14) 3790-801, Jul 15, 2014 Peer-reviewed
Neuroendocrine regulatory peptide-1 and -2 (NERPs) inhibit the excitability of magnocellular neurosecretory cells in the hypothalamus.

Koji Toshinai, Takeshi Saito, Hideki Yamaguchi, Kazuki Sasaki, Wakaba Tsuchimochi, Naoto Minamino, Yoichi Ueta, Masamitsu Nakazato

Brain research, 1563 52-60, May 14, 2014 Peer-reviewed
Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine.

Kyohei Tokizane, Hiroyuki Konishi, Masaya Yasui, Tokiko Ogawa, Kazuki Sasaki, Naoto Minamino, Hiroshi Kiyama

Molecular and cellular endocrinology, 372(1-2) 49-56, Jun 15, 2013 Peer-reviewed
Large-scale identification of endogenous secretory peptides using electron transfer dissociation mass spectrometry.

Kazuki Sasaki, Tsukasa Osaki, Naoto Minamino

Molecular & cellular proteomics : MCP, 12(3) 700-9, Mar, 2013 Peer-reviewedLead authorCorresponding author
The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.

Shintaro Shimamura, Kazuki Sasaki, Masamitsu Tanaka

The Journal of biological chemistry, 288(2) 1171-83, Jan 11, 2013 Peer-reviewed
Peptidomics Strategy for Discovering Endogenous Biologically Active Peptides

Kazuki Sasaki, Naoto Minamino

Handbook of Biologically Active Peptides, 1772-1779, 2013 Peer-reviewed
Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro.

Abu Saleh Md Moin, Hideki Yamaguchi, Marie Rhee, Ji-Wom Kim, Koji Toshinai, T M Zaved Waise, Farhana Naznin, Takashi Matsuo, Kazuki Sasaki, Naoto Minamino, Kun-Ho Yoon, Masamitsu Nakazato

Biochemical and biophysical research communications, 428(4) 512-7, Nov 30, 2012 Peer-reviewed
Molecular characterization and biological function of neuroendocrine regulatory peptide-3 in the rat.

Hiroaki Fujihara, Kazuki Sasaki, Emi Mishiro-Sato, Toyoaki Ohbuchi, Govindan Dayanithi, Motoo Yamasaki, Yoichi Ueta, Naoto Minamino

Endocrinology, 153(3) 1377-86, Mar, 2012 Peer-reviewed

Misc.

Peptidomics-based discovery of bioactive peptides: Identification of neuroendocrine regulatory peptides and their precursor processing pathway

Naoto Minamino, Kazuki Sasaki

ENDOCRINE JOURNAL, 57 S232-S232, Mar, 2010

Presentations

生理活性ペプチド探索のためのペプチドミクス

佐々木一樹

日本プロテオーム学会, Aug 10, 2022 Invited
生理活性ペプチド探索への質量分析の応用

佐々木一樹

薬学の未来を考える京都シンポジウム京都大学薬学部, Oct 5, 2013 Invited
ペプチドミクスのための質量分析

佐々木一樹

日本生化学会, Sep 22, 2011 Invited
質量分析を活用する分泌ペプチドーム解析

佐々木一樹

日本内分泌学会内分泌代謝学サマーセミナー, Jul 9, 2010 Invited
分泌顆粒内ペプチドの解析から明らかになる世界

佐々木一樹, 南野直人

日本生化学会, Oct 23, 2009 Invited
生理活性ペプチド探索のためのペプチドミクス

佐々木一樹

日本キャピラリー電気泳動学会シンポジウム, Nov 15, 2007 Invited
ペプチド性腫瘍マーカー探索のためのペプチドミクス

日本プロテオーム学会, May 20, 2005 Invited
質量分析計を用いる腫瘍マーカー探索

佐々木一樹

日本癌学会, Sep 28, 2001 Invited

Industrial Property Rights

特開2012-167017 ペプチドおよびその用途

南祇利実, 尾崎司, 佐々木一樹, 南野直人
特開2012-075408 生理活性ペプチド及びその用途

山▲崎▼ 基生, 高橋憲行, 南野直人, 佐々木一樹
特許第4926114号新規なスクリーニング法によるがんマーカーの探索

佐々木一樹, 佐藤香枝, 山口建
WO2008-090678 新規ペプチド

山▲崎▼ 基生, 高橋憲行, 南野直人, 佐々木一樹, 高尾敏文, 里見佳典, 上田陽一
WO2007-013586 新規ペプチド

山▲崎▼ 基生, 高橋憲行, 南野直人, 佐々木一樹, 高尾敏文, 里見佳典
WO2003-027138 新規なスクリーニング法によるがんマーカーの探索

佐々木一樹, 佐藤香枝, 山口建