2011年
Measles virus hemagglutinin: structural insights into cell entry and measles vaccine
FRONTIERS IN MICROBIOLOGY
- ,
- ,
- 巻
- 2
- 号
- 開始ページ
- 247
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.3389/fmicb.2011.00247
- 出版者・発行元
- FRONTIERS MEDIA SA
Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glycoproteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine.
- リンク情報
- ID情報
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- DOI : 10.3389/fmicb.2011.00247
- ISSN : 1664-302X
- PubMed ID : 22319511
- Web of Science ID : WOS:000208863500255