WAKAI Toshifumi

J-GLOBAL         Last updated: Dec 4, 2018 at 19:04
 
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Name
WAKAI Toshifumi
E-mail
wakaitmed.niigata-u.ac.jp
URL
http://www.med.niigata-u.ac.jp/su1/
Affiliation
Niigata University
Section
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Regenerative and Transplant Medicine
Job title
Professor
Other affiliation
Niigata University
Research funding number
50372470
ORCID ID
0000-0003-2443-3428

Profile

Toshifumi Wakai, MD, PhD, has been appointed to the Professor and Chairman of the Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences on December 16, 2012. I am a surgeon with special experience in hepatobiliary disease, particularly in patients with liver, bile duct, gallbladder or pancreatic cancers. I also have a lot of experience treating patients with colorectal liver metastases.

Research Areas

 
 

Academic & Professional Experience

 
Oct 2003
 - 
Mar 2005
Assistant, University Medical and Dental Hospital Intensive Care Unit, Niigata University
 
Sep 2007
 - 
Mar 2008
Assistant Professor, University Medical and Dental Hospital Surgery II, Niigata University
 
Apr 2009
 - 
Mar 2010
Assistant Professor, University Medical and Dental Hospital Supply Processing and Distribution Center, Niigata University
 
Apr 2010
 - 
Dec 2012
Lecturer, University Medical and Dental Hospital Pediatric Surgery, Niigata University
 
Dec 2012
 - 
Today
Professor, Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Regenerative and Transplant Medicine, Niigata University
 

Education

 
Apr 1986
 - 
Mar 1992
Faculty of Medicine, Yamanashi Medical University
 
Apr 1994
 - 
Mar 1999
Graduate School, Division of Medicine, Niigata University Graduate School of Medical and Dental Sciences
 

Published Papers

 
Shimada Y, Tajima Y, Nagahashi M, Ichikawa H, Oyanagi H, Okuda S, Takabe K, Wakai T
The Journal of surgical research   232 72-81   Dec 2018   [Refereed]
Yuza K, Nakajima M, Nagahashi M, Tsuchida J, Hirose Y, Miura K, Tajima Y, Abe M, Sakimura K, Takabe K, Wakai T
The Journal of surgical research   232 186-194   Dec 2018   [Refereed]
Sano K, Yamamoto M, Mimura T, Endo I, Nakamori S, Konishi M, Miyazaki M, Wakai T, Nagino M, Kubota K, Unno M, Sata N, Yamamoto J, Yamaue H, Takada T, Japanese Society of Hepato-Biliary-Pancreatic Surgery.
Journal of hepato-biliary-pancreatic sciences   25(11) 465-475   Nov 2018   [Refereed]
Yuza K, Nagahashi M, Shimada Y, Nakano M, Tajima Y, Kameyama H, Nakajima M, Takabe K, Wakai T
The Journal of surgical research   231 323-330   Nov 2018   [Refereed]
Nagahashi M, Shimada Y, Ichikawa H, Kameyama H, Takabe K, Okuda S, Wakai T
Cancer science      Oct 2018   [Refereed]
Nagahashi M, Sato S, Yuza K, Shimada Y, Ichikawa H, Watanabe S, Takada K, Okamoto T, Okuda S, Lyle S, Takabe K, Tsuchida M, Wakai T
The Journal of surgical research   230 181-185   Oct 2018   [Refereed]
Nagahashi M, Abe M, Sakimura K, Takabe K, Wakai T
Cancer science      Sep 2018   [Refereed]
Wakai T, Sakata J, Katada T, Hirose Y, Soma D, Prasoon P, Miura K, Kobayashi T
Annals of gastroenterological surgery   2(5) 359-366   Sep 2018   [Refereed]
Sunami K, Takahashi H, Tsuchihara K, Takeda M, Suzuki T, Naito Y, Sakai K, Dosaka-Akita H, Ishioka C, Kodera Y, Muto M, Wakai T, Yamazaki K, Yasui W, Bando H, Fujimoto Y, Fukuoka S, Harano K, Kawazoe A, Kimura G, Koganemaru S, Kogawa T, Kotani D, Kuboki Y, Matsumoto H, Matsumoto S, Mishima S, Nakamura Y, Sawada K, Shingaki S, Shitara K, Umemoto K, Umemura S, Yasuda K, Yoshino T, Yamamoto N, Nishio K, Japanese Society of Medical Oncology., Japan Society of Clinical Oncology., Japanese Cancer Association.
Cancer science   109(9) 2980-2985   Sep 2018   [Refereed]
[Selection of Chemotherapy Regimen on the Basis of Monitoring NLR and Soluble PD-L1 during CRC Chemotherapy].
Muneoka K, Shirai Y, Sasaki M, Honma S, Sakata J, Kanda J, Wakabayashi H, Wakai T, Miyazaki M
Gan to kagaku ryoho. Cancer & chemotherapy   45(8) 1159-1163   Aug 2018   [Refereed]
Hanyu Takaaki, Matsuki Atsushi, Kosugi Shin-Ichi, Ishikawa Takashi, Nashimoto Atsushi, Yabusaki Hiroshi, Aizawa Masaki, Ichikawa Hiroshi, Shimada Yoshifumi, Hirose Yuki, Wakai Toshifumi
Surgery   157(4) 716-722   Apr 2015
BACKGROUND: The aims of this study were to identify prognostic factors of patients with submucosa-invasive (T1b) gastric cancer and to verify the validity of adjuvant chemotherapy for this disease. METHODS: We retrospectively examined the cases o...
Ichikawa Hiroshi, Yoshida Akihiko, Kanda Tatsuo, Kosugi Shin-ichi, Ishikawa Takashi, Hanyu Takaaki, Taguchi Takahiro, Sakumoto Marimu, Katai Hitoshi, Kawai Akira, Wakai Toshifumi, Kondo Tadashi
Cancer Sci   106(1) 115-124   Jan 2015
Prognostic markers are urgently needed to optimize the postoperative treatment strategies for gastrointestinal stromal tumors (GIST). GIST of the small intestine (I-GIST) show more aggressive behavior than those of the stomach (S-GIST), and the mo...
Yajima Kazuhito, Kanda Tatsuo, Kosugi Shin-Ichi, Kano Yosuke, Ishikawa Takashi, Ichikawa Hiroshi, Hanyu Takaaki, Wakai Toshifumi
World J Gastrointest Surg   6(12) 235-240   Dec 2014
AIM: To demonstrate a new surgical technique of lower mediastinal lymphadenectomy and intrathoracic anastomosis of esophagojejunostomy using OrVil. METHODS: After a total median phrenotomy, the supradiaphragmatic and lower thoracic paraesophageal...
Shimada Yoshifumi, Kido Tomoki, Kameyama Hitoshi, Nakano Mae, Yagi Ryoma, Tajima Yosuke, Okamura Takuma, Nakano Masato, Nagahashi Masayuki, Kobayashi Takashi, Minagawa Masahiro, Kosugi Shin-Ichi, Wakai Toshifumi, Ajioka Yoichi
Surg Today      Dec 2014
PURPOSE: Perineural invasion (PN) diagnosed by hematoxylin-eosin (HE) staining is an important prognostic factor after curative-intent surgery in patients with colorectal cancer. However, the clinical significance of PN diagnosed by immunohistoche...
Kakuta Tomoyuki, Kosugi Shin-Ichi, Kanda Tatsuo, Ishikawa Takashi, Hanyu Takaaki, Suzuki Tsutomu, Wakai Toshifumi
Ann Surg Oncol   21(5) 1749-1755   May 2014
BACKGROUND: The number of patients cured of esophageal cancer after esophagectomy is gradually increasing owing to advances in surgical techniques, perioperative management, and adjuvant therapies. This study assessed the clinical course and sough...
Manba Naoko, Koyama Yu, Kosugi Shin-Ichi, Ishikawa Takashi, Ichikawa Hiroshi, Minagawa Masahiro, Kobayashi Takashi, Wakai Toshifumi
J Clin Med Res   6(1) 53-58   Feb 2014
BACKGROUND: Early enteral nutrition within 24 h after surgery has become a recommended procedure. In the present study, we retrospectively examined whether initiating EN within 24 h after esophagectomy improves the postoperative course. METHODS:...
Valproic acid overcomes transforming growth factor-beta-mediated sorafenib resistance in hepatocellular carcinoma.
Matsuda Yasunobu, Wakai Toshifumi, Kubota Masayuki, Osawa Mami, Hirose Yuki, Sakata Jun, Kobayashi Takashi, Fujimaki Shun, Takamura Masaaki, Yamagiwa Satoshi, Aoyagi Yutaka
Int J Clin Exp Pathol   7(4) 1299-1313   2014
Sorafenib is a multi-kinase inhibitor approved for hepatocellular carcinoma, but rarely causes tumor regression in patients with chronic liver diseases. To investigate whether growth factor-mediated signaling is involved in sorafenib resistance, ...
Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase.
Matsuda Yasunobu, Sanpei Ayumi, Wakai Toshifumi, Kubota Masayuki, Osawa Mami, Hirose Yuki, Sakata Jun, Kobayashi Takashi, Fujimaki Shun, Takamura Masaaki, Yamagiwa Satoshi, Yano Masahiko, Ohkoshi Shogo, Aoyagi Yutaka
Int J Clin Exp Pathol   7(5) 2032-2043   2014
Hepatitis B virus X (HBX) protein plays a crucial role in carcinogenesis, but its mechanism is unclear. The involvement of ataxia telangiectasia mutated (ATM) kinase in the enhanced redox system was investigated by examining the phosphorylation le...
Nagahashi Masayuki, Takabe Kazuaki, Terracina Krista P, Soma Daiki, Hirose Yuki, Kobayashi Takashi, Matsuda Yasunobu, Wakai Toshifumi
Biomed Res Int   2014 651727-651727   2014
Sphingosine-1-phosphate (S1P) is a pleiotropic lipid mediator that regulates cell survival, migration, the recruitment of immune cells, angiogenesis, and lymphangiogenesis, all of which are involved in cancer progression. S1P is generated inside c...
Matsuda Yasunobu, Wakai Toshifumi, Kubota Masayuki, Takamura Masaaki, Yamagiwa Satoshi, Aoyagi Yutaka, Osawa Mami, Fujimaki Shun, Sanpei Ayumi, Genda Takuya, Ichida Takafumi
Med Mol Morphol   46(4) 185-192   Dec 2013
It is well accepted that cell cycle regulators are strongly implicated in the progression of cancer development. p16 and p27 are potent cyclin-dependent kinase (CDK) inhibitors involved in G1 phase progression, and are regarded as adverse prognost...

Misc

 
【外科医が知っておくべき最新のゲノム医療】 大腸癌のゲノム医療
永橋 昌幸, 島田 能史, 市川 寛, 廣瀬 雄己, 田島 陽介, 坂田 純, 亀山 仁史, 若井 俊文
外科   80(12) 1218-1222   Nov 2018
<文献概要>次世代シークエンサーを用いた癌遺伝子パネル検査によって,RAS/RAF遺伝子をはじめとする薬剤耐性関連の遺伝子変異や,HER2遺伝子増幅などの治療標的の候補となる遺伝子変異の網羅的検索が大腸癌において可能となる.今後の遺伝子解析に備え,手術や生検組織検体の適切な保存について熟知しておくことが重要である.Lynch症候群の大腸癌はマイクロサテライト不安定性を呈し,免疫チェックポイント阻害薬が有効である可能性が示唆され注目を集めている.癌遺伝子パネル検査の普及によって,Lynch症...
【炎症性腸疾患アップデート-いま外科医に求められる知識と技術】周術期管理 炎症性腸疾患の周術期管理
亀山 仁史, 田島 陽介, 島田 能史, 山田 沙季, 阿部 馨, 田中 花菜, 小柳 英人, 中野 麻恵, 中野 雅人, 若井 俊文
臨床外科   73(12) 1394-1398   Nov 2018
<文献概要>ポイント ◆内科,外科が緊密な連携をとり,ステロイド・免疫調節薬・生物学的製剤などの薬剤管理を行う.◆炎症性腸疾患に特徴的な,日和見感染,血栓症などの合併症も考慮に入れた適切な周術期管理が重要である.◆分割手術,ストーマ管理,合併症について,適切な対応と十分なインフォームド・コンセントが必要である.
【胆道疾患診療の最前線】 胆嚢ポリープ・胆嚢癌
坂田 純, 廣瀬 雄己, 油座 築, 安藤 拓也, 相馬 大輝, 峠 弘治, 堅田 朋大, 三浦 宏平, 滝沢 一泰, 永橋 昌幸, 小林 隆, 若井 俊文
消化器外科   41(10) 1403-1410   Sep 2018
当院における外傷性脾損傷に対する治療
滝沢 一泰, 坂田 純, 若井 俊文
Japanese Journal of Acute Care Surgery   8(1) 103-103   Sep 2018
当院におけるBlumgart変法による膵空腸吻合術後膵液瘻の検討
滝沢 一泰, 坂田 純, 安藤 拓也, 油座 築, 廣瀬 雄己, 堅田 朋大, 石川 博補, 三浦 宏平, 小林 隆, 若井 俊文
日本消化器外科学会総会   73回 1000-1000   Jul 2018
直腸S状部癌は左側結腸癌として取扱うべきか、直腸癌として取扱うべきか 術後成績及び再発形式からみて
中野 雅人, 島田 能史, 田島 陽介, 亀山 仁史, 市川 寛, 永橋 昌幸, 坂田 純, 小林 隆, 瀧井 康公, 若井 俊文
日本消化器外科学会総会   73回 946-946   Jul 2018
再発膵癌に対する治療戦略 再発巣切除の意義
安藤 拓也, 滝沢 一泰, 油座 築, 廣瀬 雄己, 堅田 朋大, 石川 博補, 三浦 宏平, 坂田 純, 小林 隆, 若井 俊文
日本消化器外科学会総会   73回 927-927   Jul 2018
胆嚢癌における根治切除後再発 再発率、再発形式、危険因子、再発治療
坂田 純, 小林 隆, 滝沢 一泰, 三浦 宏平, 堅田 朋大, 石川 博補, 廣瀬 雄己, 油座 築, 安藤 拓也, 若井 俊文
日本消化器外科学会総会   73回 926-926   Jul 2018
Stage IV大腸癌における「新規病変の出現」と遺伝子変異の関連についての検討
田島 陽介, 島田 能史, 山田 沙季, 堀田 真之介, 中野 雅人, 亀山 仁史, 永橋 昌幸, 坂田 純, 小林 隆, 若井 俊文
日本消化器外科学会総会   73回 890-890   Jul 2018
Stage IV大腸癌のPrecision medicineにおけるR0切除の意義
島田 能史, 宗岡 悠介, 市川 寛, 永橋 昌幸, 田島 陽介, 中野 雅人, 坂田 純, 小林 隆, 亀山 仁史, 若井 俊文
日本消化器外科学会総会   73回 890-890   Jul 2018

Research Grants & Projects

 
Colorectal Carcinoma liver Metastases : Immunohistochemical Detection of Hepatic Micrometastases Using Monoclonal Anticytokeratin Antibody
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2003 - Mar 2004
BACKGROUND : Hepatic metastases from colorectal carcinoma frequently recur after resection and hepatic micrometastases most likely are important in the development of such recurrences. The objectives of the current study were to assess the feasibi...
Clinical significance of lymph node micrometastasis in ampullary carcinoma
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2004 - Mar 2005
This study aimed to clarify the clinical significance of lymph node micrometastasis in ampullary carcinoma. Pancreaticoduodenectomy with regional lymphadenectomy was performed for 50 consecutive patients with ampullary carcinoma. A total of 1283 r...
The mechanism and clinical significance of loss of CEACAM1 expression in hepatocellular carcinoma
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2006 - Mar 2007
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), an adhesion molecule of the immunoglobulin superfamily, has been characterized as a putative tumor suppressor because it is frequently down-regulated in aggressive types of cance...
Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2009 - Mar 2011
This study aimed to clarify the early DNA damage response mediated by 53BP1 in tumor specimens of ductal resection margins and to elucidate its predictive value for clinically evident local recurrence at ductal stumps in 110 patients undergoing re...
Mode of Hepatic Spread from Gallbladder Carcinoma : An Immunohistochemical Analysis of 42 Hepatectomized Specimens
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2009 - Mar 2011
In the current study, we analyzed the mode of hepatic spread from gallbladder carcinoma by examining immunohistochemically the resected specimens taken from 52 patients with hepatic spread. In summary, direct liver invasion and portal tract invasi...