2017年
Search for Novel Antibacterial Compounds and Targets.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- ,
- 巻
- 137
- 号
- 4
- 開始ページ
- 383
- 終了ページ
- 388
- 記述言語
- 日本語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1248/yakushi.16-00235-3
- 出版者・発行元
- PHARMACEUTICAL SOC JAPAN
Drug-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Pseudomonas aeruginosa, and vancomycin-resistant enterococci (VRE) have been spreading; however, the development of new antibacterial drugs has not progressed accordingly. Novel antibacterial drugs or their candidate seeds need to be developed for effective antibiotic therapy. Under these conditions, the search for novel compounds and novel targets is important. In Okayama University, as a part of the Drug Discovery for Intractable Infectious Diseases project, we are proceeding with the development of antibacterial drugs for the treatment of drug-resistant bacterial infections. We found that riccardin C (a natural product of liverwort) and 6,6'-dihydroxythiobinupharidine (from the crude drug Senkotsu) exhibited strong antibacterial activities, particularly against Gram-positive bacteria. We showed that riccardin C induced cell membrane leakage and that 6,6'-dihydroxythiobinupharidine inhibited DNA topoisomerase IV. Moreover, 6,6'-dihydroxythiobinupharidine exerted synergistic effects with already known anti-MRSA drugs as well as with vancomycin for VRE.
- リンク情報
- ID情報
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- DOI : 10.1248/yakushi.16-00235-3
- ISSN : 0031-6903
- PubMed ID : 28381710
- Web of Science ID : WOS:000398140000004