Toshiyuki Wakimoto

Profile Information

Affiliation: Professor, Faculty of Pharmaceutical Sciences, Hokkaido University

Degree: Ph.D.(University of Tokyo)

J-GLOBAL ID: 201501022605283747
researchmap Member ID: B000246060

External link: https://www.pharm.hokudai.ac.jp/tennen/en/

Research Interests

Research Areas

Research History

2015 - Present

教授, 薬学研究院, 北海道大学大学院
2013 - 2015

准教授, 薬学系研究科, 東京大学大学院
2010 - 2013

講師, 薬学系研究科, 東京大学大学院
2009 - 2010

School of Pharmaceutical Sciences, University of Shizuoka
2007 - 2009

School of Pharmaceutical Sciences, University of Shizuoka
2003 - 2007

School of Pharmaceutical Sciences, University of Shizuoka
2001 - 2003

博士研究員, ピッツバーグ大学化学科, 日本学術振興会海外特別研究員

Education

- 2001

東京大学大学院農学生命科学研究科
- 1996

東京大学農学部

Awards

Papers

124

Chemoenzymatic tandem cyclization for the facile synthesis of bicyclic peptides

Masakazu Kobayashi, Naho Onozawa, Kenichi Matsuda, Toshiyuki Wakimoto

Communications Chemistry, 7(1), Mar 28, 2024
Bacterial hydrazine biosynthetic pathways featuring cupin/methionyl tRNA synthetase-like enzymes.

Kenichi Matsuda, Toshiyuki Wakimoto

Chembiochem : a European journal of chemical biology, e202300874, Mar 8, 2024
Phylogeny‐guided Characterization of Bacterial Hydrazine Biosynthesis Mediated by Cupin/methionyl tRNA Synthetase‐like Enzymes

Kenichi Matsuda, Yuto Nakahara, Atina Rizkiya Choirunnisa, Kuga Arima, Toshiyuki Wakimoto

ChemBioChem, Feb 25, 2024
Animal-associated marine Acidobacteria with a rich natural-product repertoire

Stefan Leopold-Messer, Clara Chepkirui, Mathijs F.J. Mabesoone, Joshua Meyer, Lucas Paoli, Shinichi Sunagawa, Agustinus R. Uria, Toshiyuki Wakimoto, Jörn Piel

Chem, Dec, 2023
Parallel loss of sex in field populations of a brown alga sheds light on the mechanisms underlying the emergence of asexuality

Masakazu Hoshino, Guillaume Cossard, Fabian B. Haas, Emma I. Kane, Kazuhiro Kogame, Takahiro Jomori, Toshiyuki Wakimoto, Susana M. Coelho

Sep 12, 2023
Membrane‐Vesicle‐Mediated Interbacterial Communication Activates Silent Secondary Metabolite Production

Aya Yoshimura, Rio Saeki, Ryusuke Nakada, Shota Tomimoto, Takahiro Jomori, Keisuke Suganuma, Toshiyuki Wakimoto

Angewandte Chemie International Edition, Jul 14, 2023
Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis

Kuga Arima, Satoko Akiyama, Kazuo Shin-ya, Kenichi Matsuda, Toshiyuki Wakimoto

Angewandte Chemie International Edition, May 17, 2023
Streamlined Chemoenzymatic Synthesis of Cyclic Peptides by Non-ribosomal Peptide Cyclases

Masakazu Kobayashi, Kei Fujita, Kenichi Matsuda, Toshiyuki Wakimoto

Journal of the American Chemical Society, Jan 13, 2023 Peer-reviewed
Chemo-Enzymatic Synthesis of Non-ribosomal Macrolactams by a Penicillin-Binding Protein-Type Thioesterase.

Masakazu Kobayashi, Kei Fujita, Kenichi Matsuda, Toshiyuki Wakimoto

Methods in molecular biology (Clifton, N.J.), 2670 127-144, 2023
New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-austerity Agents

Jabal Haedar, Agustinus Uria, Subehan Lallo, Dya Fita Dibwe, Toshiyuki Wakimoto

Marine Drugs, 20(11) 661-661, Oct 25, 2022
New azodyrecins identified by a genome mining-directed reactivity-based screening

Atina Rizkiya Choirunnisa, Kuga Arima, Yo Abe, Noritaka Kagaya, Kei Kudo, Hikaru Suenaga, Junko Hashimoto, Manabu Fujie, Noriyuki Satoh, Kazuo Shin-ya …

Beilstein Journal of Organic Chemistry, 18 1017-1025, Aug 10, 2022
A Natural Dihydropyridazinone Scaffold Generated from a Unique Substrate for a Hydrazine-Forming Enzyme

Kenichi Matsuda, Kuga Arima, Satoko Akiyama, Yuito Yamada, Yo Abe, Hikaru Suenaga, Junko Hashimoto, Kazuo Shin-ya, Makoto Nishiyama, Toshiyuki Wakimoto

Journal of the American Chemical Society, Jun 30, 2022
Insights into Phosphatase-activated Chemical Defense in a Marine Sponge Holobiont

Takahiro Jomori, Kenichi Matsuda, Yoko Egami, Ikuro Abe, Akira Takai, Toshiyuki Wakimoto

RSC Chemical Biology, 2(6) 1600-1607, Oct, 2021 Peer-reviewed
Geographical parthenogenesis in the brown alga Scytosiphon lomentaria (Scytosiphonaceae): Sexuals in warm waters and parthenogens in cold waters

Masakazu Hoshino, Shimpei F. Hiruta, Maria Emilia Croce, Mitsunobu Kamiya, Takahiro Jomori, Toshiyuki Wakimoto, Kazuhiro Kogame

Molecular Ecology, 30(22) 5814-5830, Sep 6, 2021 Peer-reviewed
Argicyclamides A–C Unveil Enzymatic Basis for Guanidine Bis-prenylation

Chin-Soon Phan, Kenichi Matsuda, Nandani Balloo, Kei Fujita, Toshiyuki Wakimoto, Tatsufumi Okino

Journal of the American Chemical Society, Jun 28, 2021 Peer-reviewed
PenA, a penicillin-binding protein-type thioesterase specialized for small peptide cyclization.

Kenichi Matsuda, Kei Fujita, Toshiyuki Wakimoto

Journal of Industrial Microbiology & Biotechnology, 48(3-4), Jun 4, 2021 Peer-reviewed
Ascidian-associated photosymbionts from Manado, Indonesia: secondary metabolites, bioactivity simulation, and biosynthetic insight

Inneke F. M. Rumengan, Vera I. Y. Roring, Jabal R. Haedar, Mayse S. Siby, Aldian H. Luntungan, Beivy J. Kolondam, Agustinus R. Uria, Toshiyuki Wakimoto

Symbiosis, Apr 22, 2021 Peer-reviewed
Total Synthesis and Structural Revision of Kasumigamide, and Identification of a New Analogue

Takefumi Kuranaga, Kenichi Matsuda, Masachika Takaoka, Chisato Tachikawa, Ayae Sano, Kosei Itoh, Ayumu Enomoto, Kei Fujita, Ikuro Abe, Toshiyuki Wakimoto

ChemBioChem, 21(23) 3329-3332, Dec, 2020 Peer-reviewed
Heterochiral coupling in non-ribosomal peptide macrolactamization

Kenichi Matsuda, Rui Zhai, Takahiro Mori, Mazakazu Kobayashi, Ayae Sano, Ikuro Abe, Wakimoto Toshiyuki

Nature Catalysis, 32, May, 2020 Peer-reviewed
Polyketides Biosynthesis in Marine Sponges of the Family Theonellidae

Agustinus Robert Uria, Toshiyuki Wakimoto

Topics in Heterocyclic Chemistry, 389-413, 2020 Peer-reviewed

Misc.

バクテリアが有する新たな非リボソームペプチド環化酵素

松田研一, 脇本敏幸

バイオサイエンスとインダストリー, 77(4) 306‐307, Jul 10, 2019 Peer-reviewed
MyPR 未開拓天然物資源を求めて

脇本敏幸

有機合成化学協会誌, 77 72-74, 2019 Peer-reviewedInvited
ペニシリン結合タンパク質によるペプチド環化

松田研一, 倉永健史, 脇本敏幸

ファルマシア, 55 650-654, 2019 Peer-reviewed
クリルオイルに含まれる抗肥満成分の探索と作用機序解析

海野雄加, 山本宙奈, 矢澤一良, 脇本敏幸, 斧康雄

肥満研究, 23(Suppl.) 177-177, Sep, 2017
クリルオイル由来脂溶性成分による抗肥満効果の解明

海野雄加, 山本宙奈, 高槻修人, 矢澤一良, 脇本敏幸, 斧康雄

日本薬学会年会要旨集, 137年会(3) 194-194, Mar, 2017
Genome Mining of Amino Group-Carrier Protein-Mediated Machinery: Insights into Biosynthesis of Unique Hydrazone Unit

松田研一, 松田研一, 富田武郎, 志波優, 兼崎友, 吉川博文, 新家一男, 脇本敏幸, 葛山智久, 西山真

天然有機化合物討論会講演要旨集(Web), 59th, 2017
Biosynthesis of Bioactive Compounds by Marine Sponge Symbiont Bacteria

33(3) 11-17, 2016 Peer-reviewed
複合培養を用いたStreptomyces属放線菌由来新規二次代謝産物の探索

星野翔太郎, 張驪駻, 淡川孝義, 脇本敏幸, 尾仲宏康, 阿部郁朗

日本薬学会年会要旨集(CD-ROM), 135th, 2015
複合培養法によるStreptomyces属放線菌由来新規二次代謝産物の探索

星野翔太郎, ZHANG Lihan, 淡川孝義, 脇本敏幸, 尾仲宏康, 阿部郁朗

日本放線菌学会大会講演要旨集, 30th, 2015
複合培養法によりStreptomyces属放線菌から単離された新規macrolactam類の構造決定

星野翔太郎, 張恵平, 林文晶, 岡田正弘, 脇本敏幸, 尾仲宏康, 阿部郁朗

日本生薬学会年会講演要旨集, 62nd, 2015
複合培養法を利用したStreptomyces属放線菌からの新規薬用資源探索

星野翔太郎, 岡田正弘, ZHANG Huiping, 林文晶, 脇本敏幸, 尾仲宏康, 阿部郁朗

食品薬学シンポジウム講演要旨集, 6th, 2015
2S-Ep03 Chemical defense system of sponge-microbe association

Wakimoto Toshiyuki

67 266-266, 2015
カイメンー共生バクテリア系の化学防御機構

脇本敏幸, 阿部郁朗

バイオサイエンスとインダストリー, 73 49-51, 2015
海綿－共生微生物系の化学防御機構

脇本敏幸, 江上蓉子, 阿部郁朗

化学と生物, 53(8) 497-499, 2015
海綿動物の化学防御を担う共生菌

江上蓉子, 脇本敏幸, 阿部郁朗

細胞工学, 34 412-416, 2015
メディオマイシン生合成遺伝子の同定

ZHANG L., 伊藤卓也, 脇本敏幸, 淡川孝義, 浅川義範, 阿部郁朗

日本放線菌学会大会講演要旨集, 29th, 2014
メディオマイシン生合成遺伝子の同定

張驪駻, 伊藤卓也, 脇本敏幸, 淡川孝義, 浅川義範, 阿部郁朗

日本薬学会年会要旨集(CD-ROM), 134th, 2014
ミコール酸含有微生物Tsukamurella pulmonisとの複合培養による,放線菌Streptomyces属由来新規生物活性物質の探索

星野翔太郎, LIHAN Z., 淡川孝義, 脇本敏幸, 尾仲宏康, 阿部郁朗

日本放線菌学会大会講演要旨集, 29th, 2014
ミコール酸含有微生物との複合培養による,Streptomyces属放線菌由来新規生物活性物質の探索

星野翔太郎, ZHANG Lihan, 淡川孝義, 脇本敏幸, 尾仲宏康, 阿部郁朗

天然薬物の開発と応用シンポジウム講演要旨集, 20th, 2014
ミコール酸含有微生物との複合培養を用いた,放線菌Streptomyces属由来新規生物活性物質の探索

星野翔太郎, 張驪駻, 淡川孝義, 脇本敏幸, 尾仲宏康, 阿部郁朗

日本生薬学会年会講演要旨集, 61st, 2014

Books and Other Publications

天然物の化学 : 魅力と展望

上村, 大輔

東京化学同人, Jun, 2016 (ISBN: 9784807915019)

Teaching Experience

Research Projects

予知生合成科学・研究総括班

科学研究費助成事業, 学術変革領域研究(A), 日本学術振興会, Jun, 2022 - Mar, 2027

葛山智久, 内山真伸, 丸山千登勢, 寺田透, 渡辺賢二, 勝山陽平, 山崎真巳, 脇本敏幸, 大栗博毅, 淡川孝義, 荘司長三
新規ペプチド修飾酵素の機能拡張による大環状複雑骨格の創出

Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A), Grant-in-Aid for Transformative Research Areas (A), Japan Society for the Promotion of Science, Jun, 2022 - Mar, 2027
希少微生物株のゲノムマイニングによる天然医薬品資源の探索

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024

脇本敏幸
Redesigning Biosynthetic Machineries (International Activity Support Team)

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2016 - Mar, 2022

Abe Ikuro
Biosynthetic gene cluster of bioactive natural products from marine invertebrates

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

WAKIMOTO Toshiyuki
Production of rare bioactive natural products originating from uncultured bacteria

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2016 - Mar, 2021

WAKIMOTO Toshiyuki
Redesigning Biosynthetic Machineries (Project Team)

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2016 - Mar, 2021

Abe Ikuro
Biosynthetic study on bioactive compounds from marine sponges

Grants-in-Aid for Scientific Research, Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Jul, 2017 - Mar, 2019
Bioactive secondary metabolites produced by sponge symbiont Entotheonella

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

WAKIMOTO Toshiyuki, KURANAGA Takefumi, EGAMI Yoko
Collection and survey of biosynthetic genes of spore-derived biologically active substances and clarification of biosynthetic machinery

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Abe Ikuro
The mechanism regulating the function of a natural cytotoxin

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

WAKIMOTO Toshiyuki, EGAMI Yoko
Calyculin A生合成機構の解析

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015

脇本敏幸
Identification and genome analysis of bacterial symbiont producing sponge-derived secondary metabolites

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

WAKIMOTO Toshiyuki
Enzyme engineering for natural product biosynthesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

ABE IKURO, WAKIMOTO Toshiyuki, AWAKAWA Takayoshi, MATSUDA Yudai, MORITA Hiroyuki, SUGIO Shigetoshi, NOGUCHI Hiroshi, KUSHIRO Testuo
Studies on biosynthetic assembly line of meroterpenoids

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2015

ABE IKURO, MATSUDA Yudai, WAKIMOTO Toshiyuki, AWAKAWA Takayoshi, MORITA Hiroyuki
Development of selective phosphatase inhibitor based on calyculin A

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

TOSHIYUKI Wakimoto
Research for useful marineorganisms in Asia and Pacific regions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

NAKAO Yoichi, HORI Kanji, SAKAI Ryuichi, FUSETANI Nobuhiro, MATSUOKA Shunji, FUKUZAWA Seketsu, WAKIMOTO Toshiyuki, FUJITA Masaki, TAKADA Kentarou
Studies on the biological activity of furan fatty acids

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2007 - 2009

WAKIMOTO Toshiyuki

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