2020年12月
Total Synthesis and Structural Revision of Kasumigamide, and Identification of a New Analogue
ChemBioChem
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 21
- 号
- 23
- 開始ページ
- 3329
- 終了ページ
- 3332
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/cbic.202000409
- 出版者・発行元
- Wiley
© 2020 Wiley-VCH GmbH Kasumigamide is an antialgal hybrid peptide–polyketide isolated from the freshwater cyanobacterium Microcystis aeruginosa (NIES-87). The biosynthetic gene cluster was identified from not only the cyanobacterium but also Candidatus “Entotheonella”, associated with the Japanese marine sponge Discodermia calyx. Therefore, kasumigamide is considered to play a key role in microbial ecology, regardless of the terrestrial and marine habitats. We now report synthetic studies on this intriguing natural product that have led to a structural revision and the first total synthesis. During this study, a new analogue, deoxykasumigamide, was also isolated and structurally validated. This study confirmed the presence of the unusual pathway in the biosynthesis of a hybrid peptide–polyketide natural product.
- リンク情報
-
- DOI
- https://doi.org/10.1002/cbic.202000409
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/32696567
- URL
- https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.202000409
- URL
- https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cbic.202000409
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089780731&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85089780731&origin=inward
- ID情報
-
- DOI : 10.1002/cbic.202000409
- ISSN : 1439-4227
- eISSN : 1439-7633
- PubMed ID : 32696567
- SCOPUS ID : 85089780731