論文

査読有り 筆頭著者
2013年8月

Concomitant polypharmacy is associated with irinotecan-related adverse drug reactions in patients with cancer

International Journal of Clinical Oncology
  • Tetsuya Sasaki
  • ,
  • Ken-ichi Fujita
  • ,
  • Yu Sunakawa
  • ,
  • Hiroo Ishida
  • ,
  • Keishi Yamashita
  • ,
  • Keisuke Miwa
  • ,
  • Shigehira Saji
  • ,
  • Yasuhisa Kato
  • ,
  • Yasutsuna Sasaki

18
4
開始ページ
735
終了ページ
742
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10147-012-0425-5
出版者・発行元
SPRINGER JAPAN KK

Patients with cancer often receive chemotherapeutic agents concurrently with other medications to treat comorbidity. The practical effects of concomitant medications, especially polypharmacy, on adverse drug reactions related to irinotecan-based chemotherapy are not well documented.
Associations of adverse drug reactions related to irinotecan monotherapy or a combination of irinotecan, 5-fluorouracil, and l-leucovorin (FOLFIRI) with concomitant medicines used to treat comorbidity were retrospectively investigated in Japanese patients with cancer.
Of the 172 patients, 118 received concomitant medications. Twenty-one patients had grade 4 neutropenia and/or grade 3 or 4 diarrhea. Univariate and multivariate analyses revealed that concomitant medications were significantly associated with irinotecan-related severe neutropenia and/or diarrhea (P = 0.023 and 0.044). Multiple concomitant medications were significantly related to severe irinotecan-related toxicity in patients given monotherapy or FOLFIRI (P = 0.01). The incidence of severe irinotecan-related toxicities increased in parallel with the number of concomitant medications.
We found that multiple concomitant medicines were significantly associated with severe irinotecan-related toxicity, indicating that polypharmacy must be effectively managed to decrease the risk of adverse drug reactions in patients with cancer who received irinotecan-based chemotherapy.

リンク情報
DOI
https://doi.org/10.1007/s10147-012-0425-5
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000323283200027&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s10147-012-0425-5
  • ISSN : 1341-9625
  • Web of Science ID : WOS:000323283200027

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