論文

査読有り 国際誌
2008年3月

Nitric oxide generation directly responds to ultrasound exposure.

Ultrasound in medicine & biology
  • Yoichi Sugita
  • ,
  • Satoko Mizuno
  • ,
  • Naoto Nakayama
  • ,
  • Takamasa Iwaki
  • ,
  • Eiichi Murakami
  • ,
  • Zuojun Wang
  • ,
  • Reiko Endoh
  • ,
  • Hiroshi Furuhata

34
3
開始ページ
487
終了ページ
93
記述言語
英語
掲載種別
研究論文(学術雑誌)

Recently, several reports have been published on ultrasonic vascular dilation produced with relatively low-frequency ultrasound. It has been speculated that nitric oxide (NO) is an important factor for this ultrasonic vascular dilation. However, a quantitative relationship between the ultrasound intensity and NO generation was not clarified in these reports. We investigated the quantity of NO generated by various ultrasonic intensities by means of real-time measurement of NO concentration in the adductor muscles of the thigh of New Zealand white rabbits exposed to a continuous-wave ultrasound (490 kHz). In the quantitative relationship between NO generation and ultrasonic intensity, the percent increase in NO concentration was 1.25% +/- 1.25%, 10.6% +/- 2.9% and 20.1% +/- 3.5%, with the maximum muscle temperature increase 0.5 +/- 0.2 degrees C, 0.7 +/- 0.2 degrees C, and 0.8 +/- 0.3 degrees C at the ultrasonic intensity (SPTA) of 0.21, 0.35 and 0.48 W/cm(2), respectively. The effect of ultrasound on NO generation was intensity-dependent with a progressive increase from 0.21 W/cm(2) to 0.48 W/cm(2) without significant thermal effect. Ultrasonic NO generation was partially reduced by NOS inhibitor of L-NMMA, clarifying that ultrasound can activate both NOS-dependent and NOS-independent NO generation. These new findings provided scientific basis for ultrasonic vasodilatation and support the potentiality of a new ultrasonic technology for the treatment and prevention of the ischemic tissue based on the new concept of NO generated angiogenesis. (E-mail: furuhata@jikei.ac.jp).

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17933454
ID情報
  • ISSN : 0301-5629
  • PubMed ID : 17933454

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