2011年7月
Age-related change in the effect of gentle mechanical cutaneous stimulation on the somato-cardiac sympathetic C-reflex.
The journal of physiological sciences : JPS
- ,
- ,
- 巻
- 61
- 号
- 4
- 開始ページ
- 287
- 終了ページ
- 91
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12576-011-0146-y
This study examined whether aging influences the effect of gentle mechanical cutaneous stimulation (touch) on somato-cardiac sympathetic reflexes in anesthetized rats. A single electrical stimulus (15 V, 0.5 ms) applied to the tibial nerve induced somato-cardiac sympathetic A- and C-reflexes, which originated from the myelinated A- and unmyelinated C-fibers of the tibial nerve, respectively. When touch was applied to the inner thigh ipsilateral to the electrical stimulation, the C-reflex was selectively inhibited in adult rats (4-12 months), and this response was abolished by the opioid receptor antagonist, naloxone. Such an inhibitory effect of touch was impaired in aged rats (26-30 months). In contrast, depression of both A- and C-reflexes during a phenylephrine-induced rise in blood pressure was well maintained in the aged group. This study indicates that activation of the opioidergic system by gentle mechanical cutaneous stimulation attenuates with aging.
- リンク情報
- ID情報
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- DOI : 10.1007/s12576-011-0146-y
- PubMed ID : 21476123