論文

査読有り
2017年10月

Genetic Factors of Low-responsiveness to Hepatitis B Virus Vaccine Confirms the Importance of Human Leukocyte Antigen Class II Types in a Japanese Young Adult Population

ACTA MEDICA OKAYAMA
  • Nobuyasu Yukimasa
  • ,
  • Shota Kohama
  • ,
  • Wataru Oboshi
  • ,
  • Shoichi Sato
  • ,
  • Takehiro Nakamura

71
5
開始ページ
433
終了ページ
436
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18926/AMO/55442
出版者・発行元
OKAYAMA UNIV MED SCHOOL

We investigated the genetic mechanisms underlying the association between human leukocyte antigen (HLA) types and the immune response to hepatitis B virus (HBV) vaccination in 84 healthy Japanese adults, and found that the HLA-DRB1*04 and HLA-DQB1*03 frequencies were higher in the low responders (< 10 mIU/ml; n=9, 10.7%) compared to the responders (>= 10 mIU/ml, n=75, 89.3%). The combination of DRB1*04 and DQB1*03 was associated with a low response to vaccination. The DRB1*04 and DQB1*03 haplotypes' frequencies were significantly higher in the low responders compared to responders. Novel candidate HLA types may be important in Japanese individuals.


リンク情報
DOI
https://doi.org/10.18926/AMO/55442
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29042702
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418747700010&DestApp=WOS_CPL