論文

査読有り
2018年12月25日

Time-Related Changes in Relationships Between the Keys Score, Dietary Lipids, and Serum Total Cholesterol in Japan - NIPPON DATA80/90/2010.

Circulation journal : official journal of the Japanese Circulation Society
  • Yukiko Okami
  • ,
  • Hirotsugu Ueshima
  • ,
  • Yasuyuki Nakamura
  • ,
  • Keiko Kondo
  • ,
  • Aya Kadota
  • ,
  • Nagako Okuda
  • ,
  • Tomonori Okamura
  • ,
  • Katsuyuki Miura

83
1
開始ページ
147
終了ページ
155
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1253/circj.CJ-18-0628

BACKGROUND: In recent years, individuals with high serum total cholesterol (TC) have been more likely to modify their diet by reducing their intake of dietary lipids. The aim of this study was to investigate time-related changes in the relationships between the Keys score, dietary lipids, and TC between 1980 and 2010 in representative Japanese populations. Methods and Results: We used 3 cross-sectional cohort studies conducted among Japanese representative populations in 1980, 1990, and 2010 (NIPPON DATA80/90/2010) for the analyses. We analyzed data for 10,365, 7,714, and 2,657 participants, respectively, in each dataset. The relationships between TC and the Keys score (calculated by dietary lipids, cholesterol, and energy intake)/dietary lipids were examined. In men, a 1-unit higher Keys score correlated with 0.92 mg/dL and 0.64 mg/dL TC in 1980 and 1990, respectively, but not in 2010. In women, a 1-unit higher Keys score correlated with 0.70 mg/dL and 0.74 mg/dL TC in 1980 and 1990, respectively, but with 0.33 mg/dL in 2010. In men and women, dietary cholesterol, saturated fatty acid (SFA), and trans fatty acid (TFA) levels were positively associated with TC concentrations in 1980 and 1990, but not in 2010. CONCLUSIONS: In these representative Japanese populations, a higher Keys score as well as dietary cholesterol, SFA, and TFA levels correlated with higher TC concentrations in 1980/1990, but the relationships were weaker or not observed in 2010.

リンク情報
DOI
https://doi.org/10.1253/circj.CJ-18-0628
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30333434

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