論文

査読有り
2019年2月1日

The Relationship of Dietary Cholesterol with Serum Low-Density Lipoprotein Cholesterol and Confounding by Reverse Causality: The INTERLIPID Study.

Journal of atherosclerosis and thrombosis
  • Yukiko Okami
  • ,
  • Hirotsugu Ueshima
  • ,
  • Yasuyuki Nakamura
  • ,
  • Nagako Okuda
  • ,
  • Hideaki Nakagawa
  • ,
  • Kiyomi Sakata
  • ,
  • Shigeyuki Saitoh
  • ,
  • Akira Okayama
  • ,
  • Katsushi Yoshita
  • ,
  • Sohel R Choudhury
  • ,
  • Queenie Chan
  • ,
  • Paul Elliott
  • ,
  • Jeremiah Stamler
  • ,
  • Katsuyuki Miura

26
2
開始ページ
170
終了ページ
182
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.5551/jat.43075

AIM: The positive relationship between dietary cholesterol and serum cholesterol has been questioned by a set of recent cohort studies. This study aimed to investigate how employment status and education years relate to the association between dietary cholesterol and serum low-density lipoprotein cholesterol (LDL-C) in a Japanese population. METHODS: A population-based, random sample, cross-sectional study (INTERLIPID) was performed. Among 1,145 Japanese individuals aged 40-59 years, 106 were excluded because of special diets, use of lipid-lowering drugs, hormone replacement, and missing data, leaving 1,039 individuals (533 men and 506 women). Dietary cholesterol was assessed from four 24-h dietary recalls, and LDL-C was measured enzymatically with an auto-analyzer. A standard questionnaire inquired about employment status and education years. RESULTS: In men, a 1 standard deviation (SD) higher dietary cholesterol was associated with 3.16 mg/dL lower serum LDL-C (P=0.009; unadjusted model). After adjustment for covariates, higher serum LDL-C was estimated per 1 SD higher intake of dietary cholesterol in nonemployed men [self-employed, homemakers, farmers, fishermen, and retired employees; β=+9.08, 95% confidence interval (CI)=+0.90-+17.27] and less educated men (β=+4.46, 95% CI=-0.97-+9.90), whereas an inverse association was observed in employed men (β=-3.02, 95% CI=-5.49--0.54) and more educated men (β=-3.66, 95% CI=-6.25--1.07). CONCLUSIONS: In men who were nonemployed and less educated, a higher intake of dietary cholesterol was associated with elevated concentrations of serum LDL-C, whereas an inverse association was observed in men who were employed and more educated.

リンク情報
DOI
https://doi.org/10.5551/jat.43075
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29887537
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365148

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