2015年3月
The Drosophila lingerer protein cooperates with Orb2 in long-term memory formation
JOURNAL OF NEUROGENETICS
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- 巻
- 29
- 号
- 1
- 開始ページ
- 8
- 終了ページ
- 17
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3109/01677063.2014.917644
- 出版者・発行元
- INFORMA HEALTHCARE
Recently mated Drosophila females were shown to be reluctant to copulate and to exhibit rejecting behavior when courted by a male. Males that experience mate refusal by a mated female subsequently attenuate their courtship effort toward not only mated females but also virgin females. This courtship suppression persists for more than a day, and thus represents long-term memory. The courtship long-term memory has been shown to be impaired in heterozygotes as well as homozygotes of mutants in orb2, a locus encoding a set of CPEB RNA-binding proteins. We show that the impaired courtship long-term memory in orb2-mutant heterozygotes is restored by reducing the activity of lig, another putative RNA-binding protein gene, yet on its own the loss-of-function lig mutation is without effect. We further show that Lig forms a complex with Orb2. We infer that a reduction in the Lig levels compensates the Orb2 deficiency by mitigating the negative feedback for Orb2 expression and thereby alleviating defects in long-term memory.
- リンク情報
- ID情報
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- DOI : 10.3109/01677063.2014.917644
- ISSN : 0167-7063
- eISSN : 1563-5260
- PubMed ID : 24913805
- Web of Science ID : WOS:000350574400003