2020年2月
Impact of Wolbachia infection on Drosophila female germline stem cells
CURRENT OPINION IN INSECT SCIENCE
- ,
- 巻
- 37
- 号
- 開始ページ
- 8
- 終了ページ
- 15
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.cois.2019.10.001
- 出版者・発行元
- ELSEVIER
Wolbachia pipientis, one of the most dominant insect-symbiotic bacteria, highjacks the female germline of insects for its own propagation across host generations. Such strict dependence on female gametes in trans-generational propagation has driven Wolbachia to devise ingenious strategies to enhance female fertility. In Drosophila melanogaster females with female-sterile mutant alleles of the master sex-determining gene Sex-lethal (Sxl), Wolbachia colonizing female germline stem cells (GSCs) support the maintenance of GSCs, thereby rescuing the defective ovarian development. In the germ cell cytoplasm, Wolbachia are often found in proximity to ribonucleoprotein-complex processing bodies (P bodies), where the Wolbachia-derived protein TomO interacts with RNAs encoding Nanos and Orb proteins, which support the GSC maintenance and oocyte polarization, respectively. Thus, manipulation of host RNA is the key to successful vertical transmission of Wolbachia.
- リンク情報
- ID情報
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- DOI : 10.1016/j.cois.2019.10.001
- ISSN : 2214-5745
- eISSN : 2214-5753
- PubMed ID : 31726321
- Web of Science ID : WOS:000522789500003