- ELSEVIER SCIENCE BV
A rare G26 Rotavirus A strain RVA/Human-wt/NPL/07N1760/2007/G26P was detected in a child hospitalised for acute diarrhoea in Kathmandu, Nepal. The complete genome of 07N1760was determined in order to explore its evolutionary history as well as examine its relationship to a Vietnamese strain RVA/Human-wt/VNM/30378/2009/G26P, the only G26 strain whose complete genotype constellation is known. The genotype constellation of 07N1760 was G26-P[ 19]-I12-R1-C1-M1-A8-N1-T1-E1-H1, a unique constellation identical to that of the Vietnamese 30378 except the VP6 gene. Phylogenetic analysis revealed that both strains were unrelated at the lineage level despite their similar genotype constellation. The I12 VP6 gene of 07N1760 was highly divergent from the six currently deposited I12 sequences in the GenBank. Except for its NSP2 gene, the remaining genes of 07N1760 shared lineages with porcine and porcine-like human RVA genes. The NSP2 gene belonged to a human RVA N1 lineage which was distinct from typical porcine and porcine-like human lineages. In conclusion, the Nepali G26P strain 07N1760 was a porcine RVA strain which derived an NSP2 gene from a human Walike RVA strain by intra- genotype reassortment probably after transmission to the human host. (C) 2017 Elsevier B.V. All rights reserved.
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