論文

査読有り
2015年4月

Serial 3 T magnetic resonance imaging during cabergoline treatment of macroprolactinomas

NEUROLOGICAL RESEARCH
  • Masamichi Kurosaki
  • ,
  • Atsushi Kambe
  • ,
  • Takashi Watanabe
  • ,
  • Shinya Fujii
  • ,
  • Toshihide Ogawa

37
4
開始ページ
341
終了ページ
346
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1179/1743132814Y.0000000457
出版者・発行元
MANEY PUBLISHING

Objective: Cabergoline is the treatment of choice for prolactin (PRL)-producing pituitary adenomas, because of its efficacy in normalizing PRL levels, and inducing tumor shrinkage. The clinical use of 3 T magnetic resonance imaging (MRI) for neuroimaging has rapidly expanded in recent years. In particular, T2-weighted imaging (T2WI) provides high anatomical and contrast resolution.
Patients and methods: In this study, serial 3 T MRI with T2WI was utilized during cabergoline treatment of 10 patients with macroprolactinomas. Cabergoline was started at a standard weekly dosage and incrementally adjusted on individual posttreatment PRL values.
Results: MRI confirmed tumor shrinkage in all patients during cabergoline treatment. Cabergoline normalized hyperprolactinemia in all but one patient. In six of 10 patients, distinct low-signal-intensity areas were evident throughout the adenomas on T2WI. In four of those six patients, massive low-signal-intensity areas appeared at 1-4 months, after which tumors decreased in size by over 80%. These findings in the early phase of prolactinoma treatment predicted pronounced regression or near-complete disappearance of the tumor. Reduction of T2 intensity possibly reflected dehydration due to diffuse hemorrhage in the adenomas.
Conclusion: T2-weighted 3 T MR images are valuable for assessing and monitoring cabergoline treatment of macroprolactinomas.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1179/1743132814Y.0000000457
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25376133
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000347918400009&DestApp=WOS_CPL