Microstructral evolution of electron-irradiated F82H and Fe-8%Cr at 77 K was studied using positron annihilation lifetime measurements. Irradiation-induced vacancies started to migrate at 300 K and 180 K in F82H and Fe-8%Cr, respectively. Solute Cr atoms did not suppress vacancy migration, but they made di-vacancies more stable. Microvoids were not formed by annealing. In F82H, solute atoms acted as trapping site of irradiation-induced defects and annihilation of vacancies and interstitials was facilitated. Pre-existing dislocations and precipitates were also their sinks. These lead to the suppression of microvoids formation. In Fe-8%Cr, small vacancy-type dislocation loops were formed by isochronal annealing test.