Yoshihiko Kihara - My portal

Profile Information

Affiliation: 博士研究員, 血液内科, 順天堂大学

Researcher number: 70812999
J-GLOBAL ID: 202001008466178460
researchmap Member ID: R000013437

Research Interests

Research Areas

Life sciences / Hematology and oncology / 骨髄増殖性腫瘍

Research History

Apr, 2017 - Present

Juntendo University
Apr, 2015 - Mar, 2017

College of Engineering Department of Chemical Biology and Applied Chemistry, Nihon University

Education

Apr, 2011 - Mar, 2015

Graduate School of Engineering, Nihon University
Apr, 2009 - Mar, 2011

Graduate School of Engineering, Nihon University
Apr, 2005 - Mar, 2009

College of Engineering, Nihon University

Papers

Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia.

Tadaaki Inano, Marito Araki, Soji Morishita, Misa Imai, Yoshihiko Kihara, Maho Okuda, Yinjie Yang, Masafumi Ito, Satoshi Osaga, Hiroyuki Mano …

Scientific reports, 11(1) 17702-17702, Sep 6, 2021
Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface

Nami Masubuchi, Marito Araki, Yinjie Yang, Erina Hayashi, Misa Imai, Yoko Edahiro, Yumi Hironaka, Yoshihisa Mizukami, Yoshihiko Kihara, Hiraku Takei …

Leukemia, 34(2) 499-509, Feb, 2020 Peer-reviewed
癌原性を有する変異CALRの蓄積を支配するメカニズム(Mechanisms Governing the Accumulation of Mutant CALR Harboring Oncogenic Property)

Kihara Yoshihiko, Araki Marito, Yang Yinjie, Imai Misa, Masubuchi Nami, Mizukami Yoshihisa, Morishita Soji, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 65(6) 567-567, Dec, 2019
変異分子シャペロンおよびサイトカイン受容体の関与が細胞形質転換に必要である(Engagement of Mutant Molecular Chaperone and Cytokine Receptor in the Secretary is Required for the Cellular Transformation)

Masubuchi Nami, Araki Marito, Hayashi Erina, Yang Yinjie, Imai Misa, Kihara Yoshihiko, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Edahiro Yoko …

順天堂醫事雑誌, 65(6) 572-573, Dec, 2019
CALRのKDEL配列の喪失およびC末端の陰性荷電から陽性荷電アミノ酸への変化だけでは癌原性は生じない(Loss of KDEL and Conversion from Negatively to Positively Charged Amino Acids at the C-terminus of CALR Was Not Sufficient for the Oncogenicity)

Mizukami Yoshihisa, Araki Marito, Hayashi Erina, Yang Yinjie, Hironaka Yumi, Kihara Yoshihiko, Masubuchi Nami, Imai Misa, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 65(6) 580-581, Dec, 2019
変異calreticulinによるMPN発症の分子メカニズム(The Molecular Mechanism of MPN Development by Mutant Calreticulin)

Edahiro Yoko, Araki Marito, Yang Yinjie, Masubuchi Nami, Mizukami Yoshihisa, Imai Misa, Kihara Yoshihiko, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 65(6) 585-585, Dec, 2019
Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors

Tomomasa Yokomizo, Naoki Watanabe, Terumasa Umemoto, Junichi Matsuo, Ryota Harai, Yoshihiko Kihara, Eri Nakamura, Norihiro Tada, Tomohiko Sato, Tomoiku Takaku …

Journal of Experimental Medicine, 216(7) 1599-1614, Jul 1, 2019 Peer-reviewed
MPN関連 calreticulin変異による骨髄増殖性腫瘍発症の分子メカニズム

荒木真理人, 楊印杰, 増渕菜弥, 林英里奈, 水上喜久, 木原慶彦, 今井美沙, 弘中由美, ぬで島麻衣, 枝廣陽子 …

Cytometry Research, 29(Suppl.) 40-40, May, 2019
分泌経路における変異型分子シャペロンとサイトカイン受容体の会合による細胞の腫瘍化

増渕菜弥, 荒木真理人, 木原慶彦, 楊印杰, 今井美沙, 水上喜久, 林英里奈, 弘中由美, 竹井拓, 枝廣陽子 …

Cytometry Research, 29(Suppl.) 75-75, May, 2019
変異型特異的配列による変異型CALRの細胞内局在の規定

水上喜久, 荒木真理人, 今井美沙, 林絵里奈, 増渕菜弥, 楊印杰, 木原慶彦, 弘中由美, 大坂顯通, 小松則夫

Cytometry Research, 29(Suppl.) 78-78, May, 2019
Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation

Marito Araki, Yinjie Yang, Misa Imai, Yoshihisa Mizukami, Yoshihiko Kihara, Yoshitaka Sunami, Nami Masubuchi, Yoko Edahiro, Yumi Hironaka, Satoshi Osaga …

Leukemia, 33(1) 122-131, Jan, 2019 Peer-reviewed
変異calreticulinの蓄積を支配するメカニズム(Mechanisms Governing the Accumulation of Mutant Calreticulin)

Kihara Yoshihiko, Araki Marito, Yang Yinjie, Imai Misa, Masubuchi Nami, Mizukami Yoshihisa, Hironaka Yumi, Morishita Soji, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 64(6) 479-480, Dec, 2018
変異calreticulinの腫瘍形成能には分泌経路の構築が必要である(Boarding the Secretory Pathway Is Required for the Oncogenic Capacity of Mutant Calreticulin)

Masubuchi Nami, Araki Marito, Hayashi Erina, Yang Yinjie, Imai Misa, Kihara Yoshihiko, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Edahiro Yoko …

順天堂醫事雑誌, 64(6) 480-480, Dec, 2018
変異分子シャペロンはサイトカイン受容体の構成的活性化を介して細胞形質転換を誘導する(A Mutant Molecular Chaperone Induces Cellular Transformation by Constitutive Activation of a Cytokine Receptor)

Araki Marito, Yang Yinjie, Masubuchi Nami, Imai Misa, Hironaka Yumi, Takei Hiraku, Kihara Yoshihiko, Mizukami Yoshihisa, Edahiro Yoko, Ohsaka Akimichi …

順天堂醫事雑誌, 64(6) 486-487, Dec, 2018
ヒト巨核球系UT-7/TPO細胞における癌原性変異calreticulinをモニタリングする生細胞イメージングシステムの開発(Establishment of a Live-Imaging System Monitoring the Oncogenic Mutant Calreticulin in Human Megakaryocytic UT-7/TPO Cells)

Mizukami Yoshihisa, Araki Marito, Hayashi Erina, Yang Yinjie, Hironaka Yumi, Kihara Yoshihiko, Masubuchi Nami, Imai Misa, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 64(6) 494-495, Dec, 2018
変異型CALRの多量体化はMPLとの結合と活性化に必須である(Homomultimerization of mutant calreticulin is required for MPL-binding and -activation)

荒木真理人, 楊印杰, 今井美沙, 水上喜久, 木原慶彦, 角南義孝, 増渕菜弥, 枝廣陽子, 弘中由美, 大佐賀智 …

臨床血液, 59(9) 1613-1613, Sep, 2018
Localization of Mutant Calreticulin in the Golgi Apparatus Is Required for Its Oncogenic Capacity

Masubuchi Nami, Araki Marito, Hayashi Erina, Yang Yinjie, Imai Misa, Kihara Yoshihiko, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Edahiro Yoko …

BLOOD, 130, Dec 7, 2017 Peer-reviewed
骨髄増殖性腫瘍に見出される変異型CALR蛋白質の細胞内局在

林英里奈, 荒木真理人, 増渕菜弥, 水上喜久, 楊印杰, 今井美沙, 弘中由美, 竹井拓, 木原慶彦, 枝廣陽子 …

臨床血液, 58(9) 1657-1657, Sep, 2017
MPLの活性化は変異型のCALRとMPLの細胞内のおける相互作用を必要とする(Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation)

Masubuchi Nami, Araki Marito, Hayashi Erina, Yang Yinjie, Imai Misa, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Morishita Soji, Kihara Yoshihiko …

臨床血液, 58(9) 1521-1521, Sep, 2017
変異型CALRタンパク質の発現を制御するメカニズム(Mechanisms governing the accumulation of mutant calreticulin)

Kihara Yoshihiko, Araki Marito, Yang Yinjie, Imai Misa, Masubuchi Nami, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Edahiro Yoko, Ohsaka Akimichi …

臨床血液, 58(9) 1658-1658, Sep, 2017

Major Presentations

Therapeutic potential of an antibody targeting the cleaved form of mutant calreticulin in myeloproliferative neoplasms

Kihara Y, Araki M, Imai M, Mori Y, Horino M, Ogata S, Yoshikawa S, Taguchi T, Masubuchi N, Mabuchi Y, Yang Y, Fukuda Y, Morishita S, Suzuki T, Domae N, Shimonaka M, Akazawa C, Ohsaka A, Komatsu N

62nd ASH Annual Meeting, Dec 7, 2020
Therapeutic potential of myeloproliferative neoplasms by antibody targeting mutant calreticulin

Kihara Y, Araki M, Imai M, Fukuda Y, Mori Y, Taguchi T, Masubuchi N, Mabuchi Y, Yang Y, Mizukami Y, Morishita S, Akazawa C, Ohsaka A, Komatsu N

The 82nd Annual Meeting of the Japanese Society of Hematology, Oct 11, 2020

Professional Memberships

Oct, 2017 - Present

日本血液学会

Research Projects

変異型CALR蛋白質の切断による骨髄増殖性腫瘍発症の抑止

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2021 - Mar, 2024

木原慶彦
Mechanisms governing intracellular accumulation of mutant CALR proteins

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Yoshihiko Kihara

Major Industrial Property Rights

特許PCT/JP2020/008434 切断型の変異型Calreticulinに結合する抗体、及び骨髄増殖性腫瘍の診断、予防又は治療薬

荒木真理人, 小松則夫, 木原慶彦