Yuya Morimoto

J-GLOBAL         Last updated: Dec 3, 2019 at 23:32
Yuya Morimoto
The University of Tokyo
Institute of Industrial Science

Research Areas


Published Papers

Dong Chel Shin, Yuya Morimoto, Jun Sawayama, Shigenori Miura, Shoji Takeuchi
Sensors and Actuators, B: Chemical   301    Dec 2019
© 2019 Monodisperse picoliter droplets have been widely used for biochemical reactors and preparation of functional microbeads for food, cosmetics, and medical industry. Although conventional microfluidic technologies enable the production of mono...
Akiyo Yokomizo, Yuya Morimoto, Keigo Nishimura, Shoji Takeuchi
Micromachines   10    Jun 2019
© 2019 by the authors. In this paper, we propose an anchoring device with pillars to immobilize an adipocyte microfiber that has a fiber-shaped adipocyte tissue covered by an alginate gel shell. Because the device enabled the immobilization of the...
Yuya Morimoto, Hiroaki Onoe, Shoji Takeuchi
Advanced Robotics   33 208-218   Mar 2019
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group and The Robotics Society of Japan. This paper describes a fabrication method and driving property of a biohybrid device with an antagonistic pair of skeletal muscle tissues and...
Nobuhito Mori, Yuya Morimoto, Shoji Takeuchi
Biofabrication   11    Jan 2019
© 2018 IOP Publishing Ltd. This study describes a perfusable and stretchable culture system for a skin-equivalent. The system is comprised of a flexible culture device equipped with connections that fix vascular channels of the skin-equivalent and...
Yusuke Hirata, Yuya Morimoto, Eunryel Nam, Shoji Takeuchi
Lab on a Chip   19 1971-1976   Jan 2019
© 2019 The Royal Society of Chemistry. Biohybrid odorant sensors (BOSs) composed of biological materials and artificial detectors have recently attracted much attention due to their high degree of sensitivity and selectivity. Although portability ...
Yuya Morimoto, Mahiro Kiyosawa, Shoji Takeuchi
Sensors and Actuators, B: Chemical   274 491-500   Nov 2018   [Refereed]
© 2018 Elsevier B.V. Coaxial microfluidic devices have been widely used for the preparation of monodisperse droplets and multi-layered hydrogel fibers. However, in the formation of the coaxial microfluidic devices, as the configurations of the coa...
Shotaro Yoshida, Yuya Morimoto, Lanying Zheng, Hiroaki Onoe, Shoji Takeuchi
Soft robotics      Oct 2018   [Refereed]
Ai Shima, Yuya Morimoto, H. Lee Sweeney, Shoji Takeuchi
Experimental Cell Research   370 168-173   Sep 2018   [Refereed]
© 2018 Elsevier Inc. This paper describes a method to construct three-dimensional (3D) contractile human skeletal muscle tissues from a cell line. The 3D tissue was fabricated as a fiber-based structure and cultured for two weeks under tension by ...
Keigo Nishimura, Yuya Morimoto, Nobuhito Mori,Shoji Takeuchi
Micromachines   9 303   Jun 2018   [Refereed]
© 2018 by the authors. This study proposes a microfluidic spinning method to form alginate microfibers with branched and chained structures by controlling two streams of a sodium alginate solution extruded from a theta-glass capillary (a double-co...
Lorenzo Moroni, Jason A. Burdick, Christopher Highley, Sang Jin Lee, Yuya Morimoto, Shoji Takeuchi, James J. Yoo
Nature Reviews Materials   3 21-37   May 2018   [Refereed]
© 2018 Macmillan Publishers Ltd., part of Springer Nature. Organs are complex systems composed of different cells, proteins and signalling molecules that are arranged in a highly ordered structure to orchestrate a myriad of functions in our body. ...
Yuya Morimoto, Hiroaki Onoe, Shoji Takeuchi
Science Robotics   3(18) eaat4440   May 2018   [Refereed]
Yuya Morimoto, Maiko Onuki, Shoji Takeuchi
Advanced Healthcare Materials   6(13) 1601375   Jul 2017   [Refereed]
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim This paper describes a centrifuge-based device for oil-free and mass production of calcium-alginate (Ca-alginate) particles. The device is composed of four components: a tank with a glass capilla...
Naoko Ueno, Taisuke Banno, Arisa Asami, Yuki Kazayama, Yuya Morimoto, Toshihisa Osaki, Shoji Takeuchi, Hiroyuki Kitahata, Taro Toyota
Langmuir   33 5393-5397   Jun 2017   [Refereed]
© 2017 American Chemical Society. We evaluated the speed profile of self-propelled underwater oil droplets comprising a hydrophobic aldehyde derivative in terms of their diameter and the surrounding surfactant concentration using a microfluidic de...
Nobuhito Mori, Yuya Morimoto, Shoji Takeuchi
Biomaterials   116 48-56   Feb 2017   [Refereed]
© 2016 Elsevier Ltd This paper describes a method for fabricating perfusable vascular channels coated with endothelial cells within a cultured skin-equivalent by fixing it to a culture device connected to an external pump and tubes. A histological...
Satoshi Fujii, Aiko Nobukawa, Toshihisa Osaki, Yuya Morimoto, Koki Kamiya, Nobuo Misawa, Shoji Takeuchi
Lab on a Chip   17 2421-2425   Jan 2017   [Refereed]
© The Royal Society of Chemistry 2017. A pesticide vapor sensor was developed using an agarose gel-based chip containing a nanopore sensing system. Vaporized omethoate was detected by the absorption into the gel, the complex formation with a DNA a...
Nobuhito Mori, Yuya Morimoto, Shoji Takeuchi
Journal of Bioscience and Bioengineering   122 753-757   Dec 2016   [Refereed]
© 2016 The Society for Biotechnology, Japan Vessel-like channels fabricated by embedding sacrificial structures in three-dimensional (3D) cellular constructs and then removing the sacrificial structures have been proposed as a means of providing n...
Yuya Morimoto, Yumi Mukouyama, Shohei Habasaki, Shoji Takeuchi
Micromachines   7 39   Mar 2016   [Refereed]
© 2016 by the authors. In this paper, we propose a balloon pump with floating valves to control the discharge flow rates of sample solutions. Because the floating valves were made from a photoreactive resin, the shapes of the floating valves could...
Yuya Morimoto, Saori Mori, Fusako Sakai, Shoji Takeuchi
Lab on a Chip   16 2295-2301   Jan 2016   [Refereed]
© 2016 The Royal Society of Chemistry. We propose a method for the production of a fiber-shaped three-dimensional (3D) cellular construct of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) for the quantification of the contra...
Yuya Morimoto, Amy Y. Hsiao, Shoji Takeuchi
Advanced Drug Delivery Reviews   95 29-39   Dec 2015   [Refereed]
© 2015 Elsevier B.V. Microsized cellular constructs such as cellular aggregates and cell-laden hydrogel blocks are attractive cellular building blocks to reconstruct 3D macroscopic tissues with spatially ordered cells in bottom-up tissue engineeri...
Yoshinobu Iimura, Hiroaki Onoe, Tetsuhiko Teshima, Yun Jung Heo, Shotaro Yoshida, Yuya Morimoto, Shoji Takeuchi
Journal of Micromechanics and Microengineering   25 035030   Mar 2015   [Refereed]
© 2015 IOP Publishing Ltd. This paper describes a liquid-filled tunable lenticular lens for switching between two-dimensional (2D) and three-dimensional (3D) images in naked-eye 3D displays. Compared with previous 2D/3D switchable displays, this t...
Sachine Yoshida, Yuya Morimoto, Taishi Tonooka, Shoji Takeuchi
Journal of Neuroscience Methods   243 63-67   Mar 2015   [Refereed]
© 2015 Elsevier B.V. Background: Mouse pups are invaluable model animals for understanding the molecular and neural basis underlying behavioral development. Stereotaxic operations with anesthetic control are useful tools in systems neuroscience. H...
Midori Kato-Negishi,Yuya Morimoto, Hiroaki Onoe, Shoji Takeuchi
Advanced Healthcare Materials   2 1564-1570   Dec 2013   [Refereed]
A millimeter-sized neural building block (NBB) shows high versatility to form a 3D heterogeneous neural component. A millimeter-sized 3D neural network between heterogeneous neural tissues is established, and an efficient technique is then develop...
Yuya Morimoto, Midori Kato-Negishi, Hiroaki Onoe, Shoji Takeuchi
Biomaterials   34 9413-9419   Dec 2013   [Refereed]
This paper describes a fabrication method of muscle tissue constructs driven by neurotransmitters released from activated motor neurons. The constructs consist of three-dimensional (3D) free-standing skeletal muscle fibers co-cultured with motor n...
Yuya Morimoto, Shoji Takeuchi
Biomaterials Science   1 257-264   Mar 2013   [Refereed]
This mini-review consists of microfluidic fabrication methods of cellular spheroids and cell-laden hydrogels, and their applications for tissue engineering. Using microfluidic devices, cellular spheroids and cell-laden hydrogels with controllable ...
Yuya Morimoto, Risa Tanaka, Shoji Takeuchi
Advanced Healthcare Materials   2 261-265   Feb 2013   [Refereed]
Yuya Morimoto, Kaori Kuribayashi-Shigetomi, Shoji Takeuchi
Journal of Micromechanics and Microengineering   21 054031   May 2011   [Refereed]
A combination of photolithography and stereolithography was successfully used to fabricate a hybrid axisymmetric flow-focusing device (h-AFFD) that produces monodisperse picoliter droplets. The h-AFFD achieved the same level of hydrodynamic perfor...
*Yukiko T. Matsunaga, *Yuya Morimoto, Shoji Takeuchi (*:equal contribution)
Advanced Materials   23(12) H90-H94   Mar 2011   [Refereed]
A microfluidic system was used to prepare a large number of size-controlled collagen gel beads to form microtissue units, "cell beads", as tissue building blocks. By stacking cell beads into a doll-shaped silicone chamber, millimeter-thick tissue ...
Yukiko Tsuda, Yuya Morimoto, Shoji Takeuchi
Langmuir   26 2645-2649   Feb 2010   [Refereed]
This paper describes a method to produce monodisperse cell-encapsulating microgel beads composed of a selfassembling peptide gel for three-dimensional (3D) cell culture. We used a 3D microfluidic axisymmetric flow-focusing device with an external ...
Seibutsu Butsuri   50(1) 38-41   Jan 2010   [Refereed]
Yuya Morimoto, Wei Heong Tan, Shoji Takeuchi
Biomedical Microdevices   11 369-377   Jan 2009   [Refereed]
This paper describes a three-dimensional microfluidic axisymmetric flow-focusing device (AFFD) fabricated using stereolithography. Using this method, we can fabricate AFFDs rapidly and automatically without cumbersome alignment needed in conventio...
Yuya Morimoto, Wei Heong Tan, Yukiko Tsuda, Shoji Takeuchi
Lab on a Chip   9 2217-2223   Jan 2009   [Refereed]
We present a method for forming monodisperse semi-permeable microcapsules composed of an alginate-poly-l-lysine (PLL) membrane for the observation of encapsulated cells. These microcapsules were prepared with a monolithic three-dimensional microfl...

Books etc

Applications of Microfluidic Systems in Biology and Medicine
Yuya Morimoto, Nobuhito Mori and Shoji Takeuchi (Part:Contributor, pp. 247-274「In vitro tissue construction for organ-on-a-chip application」)
Springer   2019   


Dong Chel Shin, Yuya Morimoto, Shoji Takeuchi
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)   2019-January 404-405   Jan 2019
© 2019 IEEE. We propose a centrifuge-based microfluidic device housed in a standard microtube for generation of monodisperse microdroplets from tens of \mu \mathrm{l} sample volume. Centrifugation drives overpressure of a dispersed phase, thus inf...
Yuya Morimoto, Jun Sawayama, Shoji Takeuchi
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)   2019-January 584-585   Jan 2019
© 2019 IEEE. We propose a method for in situ continuous and dynamic glucose monitoring in cultured skeletal muscle tissue using a glucose responsive hydrogel fiber. In the skeletal muscle tissue, the fiber emits fluorescence according to glucose c...
Yusuke Hirata, Yuya Morimoto, Shoji Takeuchi
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)   2018-January 304-307   Apr 2018
© 2018 IEEE. We propose a gaseous odorant detection system by combination of a collagen pedestal and micro collagen pillars containing cells expressing olfactory receptor. The collagen pedestal allowed to bring cells close air-liquid surface witho...
Nobuhito Mori, Yuya Morimoto, Shoji Takeuchi
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)   2018-January 322-325   Apr 2018
© 2018 IEEE. This conference proceeding reports a system for measuring transendothelial electrical resistance (TEER) of 3D tubular vascular channel as an index of endothelial barrier integrity. We introduced an electrodes-pair into the channel ins...
Kaori Furuike, Ai Shima, Yuya Morimoto, Shoji Takeuchi
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)   2018-January 336-339   Apr 2018
© 2018 IEEE. We propose pneumatically driven PDMS micropillars (PDMS actuator) for the investigation of intercellular communication at a single-cell level. Cells usually organize large and complex networks. For detailed investigation of intercellu...