SHIWAKU Yukari

J-GLOBAL         Last updated: Aug 2, 2019 at 15:42
 
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Name
SHIWAKU Yukari
Affiliation
Tohoku University
Section
Graduate School of Dentistry

Published Papers

 
Yukari Shiwaku, Kaori Tsuchiya, Linghao Xiao, Osamu Suzuki
Journal of Biomedical Materials Research - Part A   107(5) 1001-1013   May 2019   [Refereed]
© 2019 Wiley Periodicals, Inc. Previous studies have reported that octacalcium phosphate (OCP) enhances osteoblast differentiation and osteoclast formation during the hydrolysis process to hydroxyapatite (HA). However, the crystal phases that affe...
Tomoya Sato, Takahisa Anada, Ryo Hamai, Yukari Shiwaku, Kaori Tsuchiya, Susumu Sakai, Kazuyoshi Baba, Keiichi Sasaki, Osamu Suzuki
Acta Biomaterialia   88 477-490   Apr 2019   [Refereed]
© 2019 Acta Materialia Inc. Three-dimensional (3-D) cell culture can better mimic physiological conditions in which cells interact with adjacent cells and the extracellular matrix than monolayer culture. We have developed a 3-D cell culture device...
Tsuyoshi Kurobane, Yukari Shiwaku, Takahisa Anada, Ryo Hamai, Kaori Tsuchiya, Kazuyoshi Baba, Masahiro Iikubo, Tetsu Takahashi, Osamu Suzuki
Acta Biomaterialia   88 514-526   Apr 2019   [Refereed]
© 2019 Acta Materialia Inc. Effect of octacalcium phosphate/gelatin composite (OCP/Gel) on angiogenesis was studied by its implantation in rat calvaria critical-sized defect in relation to bone regeneration for 2 and 4 weeks. The implantation of O...
Sei Tsutsui, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Hajime Yamazaki, Osamu Suzuki
Journal of Biomedical Materials Research - Part B Applied Biomaterials   106(6) 2235-2244   Aug 2018   [Refereed]
© 2017 Wiley Periodicals, Inc. The present study was designed to characterize co-precipitated fluoridated apatitic materials from octacalcium phosphate (OCP) precursor and to investigate their surface reactions with polyols including glycerol in t...
Ryosuke Iwama, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Tetsu Takahashi, Osamu Suzuki
Journal of Biomedical Materials Research - Part A   106(5) 1322-1333   May 2018   [Refereed]
© 2018 Wiley Periodicals, Inc. The activity and the distribution of osteogenic cells around octacalcium phosphate (OCP) granules combined with gelatin matrix (OCP/Gel) onlaid on rat calvaria were analyzed histomorphometrically and immunohistochemi...
Yuko Sai, Yukari Shiwaku, Takahisa Anada, Kaori Tsuchiya, Tetsu Takahashi, Osamu Suzuki
Acta Biomaterialia   69 362-371   Mar 2018   [Refereed]
© 2018 Acta Materialia Inc. Octacalcium phosphate (OCP) has been shown to act as a nucleus for initial bone deposition and enhancing the early stages of osteoblastic differentiation. However, the effect on differentiation at the late stage into os...
Sei Tsutsui, Takahisa Anada, Yukari Shiwaku, Atsushi Yamagishi, Osamu Suzuki
Journal of Hard Tissue Biology   27(1) 34-38   Jan 2018   [Refereed]
© 2018 The Hard Tissue Biology Network Association Printed in Japan, All rights reserved. The present study investigated how polyols (sugar alcohols) affect the formation of calcium fluoride (CaF2) in the presence of fluoride on synthetic hydroxya...
Shinpei Chiba, Takahisa Anada, Kentaro Suzuki, Keisuke Saito, Yukari Shiwaku, Naohisa Miyatake, Kazuyoshi Baba, Hideki Imaizumi, Masami Hosaka, Eiji Itoi, Osamu Suzuki
Journal of Biomedical Materials Research - Part A   104(11) 2833-2842   Nov 2016   [Refereed]
© 2016 Wiley Periodicals, Inc. The purpose of this study was to compare the biodegradation rate and quality of regenerated bone among four materials. A short time period of 8 weeks was chosen to examine early bone healing. The rod-shaped implants ...
Takuo Kamoya, Takahisa Anada, Yukari Shiwaku, Teruko Takano-Yamamoto, Osamu Suzuki
Sensors and Actuators, B: Chemical   232 75-83   Sep 2016   [Refereed]
© 2016 Elsevier B.V. All rights reserved. Mesenchymal stem cells (MSCs) are being clinically used for bone and cartilage regeneration. However, the preparation of MSCs for implantation is still costly and time consuming, and controlling the differ...
Takahisa Anada, Tomoya Sato, Takuo Kamoya, Yukari Shiwaku, Kaori Tsuchiya, Teruko Takano-Yamamoto, Keiichi Sasaki, Osamu Suzuki
Regenerative Therapy   3 58-62   Mar 2016   [Refereed]
© 2016 The Japanese Society for Regenerative Medicine. Much attention has been paid to three-dimensional cell culture systems in the field of regenerative medicine, since three-dimensional cellular aggregates, or spheroids, are thought to better m...
Keisuke Saito, Takahisa Anada, Yukari Shiwaku, Shinpei Chiba, Naohisa Miyatake, Kentaro Suzuki, Kaori Tsuchiya, Osamu Suzuki
RSC Advances   6(69) 64165-64174   Jan 2016   [Refereed]
© 2016 The Royal Society of Chemistry. The present study was designed to investigate how the dose of granular octacalcium phosphate (OCP) in a gelatin (Gel) matrix affects its bone regenerative and biodegradable properties in a rabbit tibia defect...
Mayu Tadaki, Takahisa Anada, Yukari Shiwaku, Takashi Nakamura, Masanori Nakamura, Masaru Kojima, Tatsuo Arai, Satoshi Fukumoto, Osamu Suzuki
RSC Advances   6(67) 62109-62118   Jan 2016   [Refereed]
© 2016 The Royal Society of Chemistry. The present study was designed to investigate whether a three dimensional (3D) culture of the rat incisor-derived dental epithelial cell line SF2 enhances its differentiation into ameloblast-like cells. SF2 c...
Bunichi Hirayama, Takahisa Anada, Yukari Shiwaku, Naohisa Miyatake, Kaori Tsuchiya, Masanori Nakamura, Tetsu Takahashi, Osamu Suzuki
RSC Advances   6(62) 57475-57484   Jan 2016   [Refereed]
© The Royal Society of Chemistry 2016. The present study was designed to investigate how octacalcium phosphate (OCP) induces an immune response and whether the response is involved in the biodegradation and subsequent bone formation by OCP implant...
Yukari Shiwaku, Lynn Neff, Kenichi Nagano, Ken Ichi Takeyama, Joost De Bruijn, Michel Dard, Francesca Gori, Roland Baron
PLoS ONE   10(7)    Jul 2015   [Refereed]
© 2015 Shiwaku et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are...
Kei Ichiro Miura, Takahisa Anada, Yoshitomo Honda, Yukari Shiwaku, Tadashi Kawai, Seishi Echigo, Tetsu Takahashi, Osamu Suzuki
Applied Surface Science   282 138-145   Oct 2013   [Refereed]
The present study was designed to investigate the physicochemical and bioactive properties of a nano-submicro sized octacalcium phosphate (OCP)-dispersed gelatin (Gel) composite (nano-submicro OCP/Gel) used as a bone substitute material in various...
Y. Shiwaku, T. Anada, H. Yamazaki, Y. Honda, S. Morimoto, K. Sasaki, O. Suzuki
Acta Biomaterialia   8 4417-4425   Dec 2012
Octacalcium phosphate (OCP) has been reported to stimulate bone regeneration during hydrolysis into hydroxyapatite (HA). The present study was designed to characterize structural, morphological and surface properties of fluoride-containing apatiti...
Yoshitomo Honda, Takahisa Anada, Shinji Morimoto, Yukari Shiwaku, Osamu Suzuki
Crystal Growth and Design   11(5) 1462-1468   May 2011   [Refereed]
Zinc (Zn) ions and OCP crystals have both been reported to be stimulants for bone formation. The present study was designed to investigate how Zn ion affects the precipitation of octacalcium phosphate (OCP) and its hydrolysis process into apatitic...
Yukari Shiwaku, Yoshitomo Honda, Takahisa Anada, Shinji Morimoto, Taisuke Masuda, Keiichi Sasaki, Osamu Suzuki
Journal of the Ceramic Society of Japan   118(1378) 402-405   Jan 2010   [Refereed]
The present study was designed to determine the physicochemical properties of octacalcium phosphate (OCP) and its products obtained by different preparations in the presence of fluoride ions (F-) through hydrolysis of the synthesized OCP and copre...
Takeshi Fuji, Takahisa Anada, Yoshitomo Honda, Yukari Shiwaku, Hiroko Koike, Shinji Kamakura, Keiichi Sasaki, Osamu Suzuki
Tissue Engineering - Part A   15(11) 3525-3535   Nov 2009   [Refereed]
The present study was designed to investigate whether octacalcium phosphate (OCP)-precipitated alginate (Alg) promotes osteoblastic cell proliferation and bone regeneration in comparison with Alg itself. Alg, known to lack mammal cell attachment c...

Conference Activities & Talks

 
Kazuyoshi Baba, Yukari Shiwaku, Takahisa Anada, Yu Mori, Kaori Tsuchiya, Eiji Itoi, Osamu Suzuki
Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium   1 Jan 2019   
© 2019 Omnipress - All rights reserved. Statement of Purpose: We have reported that octacalcium phosphate (OCP) exhibits direct bone bonding property 1 and has in vitro stimulatory capacities on osteoblastic cell differentiation from bone marrow ...
Takahisa Anada, Mayu Tadaki, Yukari Shiwaku, Takashi Nakamura, Masanori Nakamura, Masaru Kojima, Tatsuo Arai, Satoshi Fukumoto, Osamu Suzuki
2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016   18 Jan 2017   
© 2016 IEEE. We have developed three-dimensional (3D) cell culture devices. The present study investigated that the effect of 3D culture of rat incisor-derived dental epithelial cells on their differentiation into ameloblast-like cells.