薗部佳史 (Yoshifumi Sonobe) - マイポータル

基本情報

所属: University of Chicago Medical Center Research Professional, Sr. Analyst

学位: 博士（医学）(2008年3月名古屋大学)

研究者番号: 20534845
J-GLOBAL ID: 202201020306780460
researchmap会員ID: R000038755

研究キーワード

神経科学、神経免疫学、分子生物学、細胞生物学

研究分野

ライフサイエンス / 神経科学一般 / 神経科学、神経免疫学、分子生物学、細胞生物学

経歴

2021年8月 - 現在

University of Chicago, Medical Center, Research Professional, Sr. Analyst
2015年6月 - 2021年7月

University of Chicago, Medical Center, Research Professional
2014年6月 - 2015年5月

University of Chicago, Medical Center, Postdoctoral Scholar
2013年8月 - 2014年5月

Thomas Jefferson University, Visiting Researcher
2013年4月 - 2013年7月

名古屋大学環境医学研究所, 客員研究者
2008年11月 - 2013年3月

名古屋大学大学院医学系研究科, GCOE特任助教
2008年4月 - 2008年10月

名古屋大学環境医学研究所, 機関研究員

学歴

2004年4月 - 2008年3月

名古屋大学大学院, 医学系研究科

受賞

論文

Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions

Alec C. Gleason, Ghanashyam Ghadge, Jin Chen, Yoshifumi Sonobe, Raymond P. Roos

PLoS One 17(6) e0256411-e0256411 2022年6月1日査読有り
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.

Yoshifumi Sonobe, Jihad Aburas, Gopinath Krishnan, Andrew C Fleming, Ghanashyam Ghadge, Priota Islam, Eleanor C Warren, Yuanzheng Gu, Mark W Kankel, André E X Brown …

Nature Communications 12(1) 6025 2021年10月15日査読有り筆頭著者
RNA-binding protein altered expression and mislocalization in MS.

Katsuhisa Masaki, Yoshifumi Sonobe, Ghanashyam Ghadge, Peter Pytel, Paula Lépine, Florian Pernin, Qiao-Ling Cui, Jack P Antel, Stephanie Zandee, Alexandre Prat …

Neurology Neuroimmunology & Neuroinflammation 7(3) e704 2020年5月査読有り
Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS.

Ghanashyam D Ghadge, Yoshifumi Sonobe, Adrian Camarena, Claire Drigotas, Frank Rigo, Karen K Ling, Raymond P Roos

Neurobiology of Disease 136 104702 2020年3月査読有り
TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection.

Katsuhisa Masaki, Yoshifumi Sonobe, Ghanashyam Ghadge, Peter Pytel, Raymond P Roos

PLoS Pathogens 15(2) e1007574 2019年2月査読有り
Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress.

Yoshifumi Sonobe, Ghanashyam Ghadge, Katsuhisa Masaki, Ataman Sendoel, Elaine Fuchs, Raymond P Roos

Neurobiology of Disease 116 155-165 2018年8月査読有り筆頭著者
Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway (vol 1322, pg 8, 2010)

Jianfeng Liang, Hideyuki Takeuchi, Shijie Jin, Mariko Noda, Hua Li, Yukiko Doi, Jun Kawanokuchi, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumura

BRAIN RESEARCH 1644 306-307 2016年8月査読有り
Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cϵ-dependent manner.

Sonobe Y, Takeuchi H, Kataoka K, Li H, Jin S, Mimuro M, Hashizume Y, Sano Y, Kanda T, Mizuno T …

The Journal of biological chemistry 291(24) 12573-12573 2016年6月査読有り
FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway.

Mariko Noda, Kento Takii, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura

Journal of Neuroinflammation 11 76 2014年4月16日査読有り
Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes.

Yi Cheng, Hideyuki Takeuchi, Yoshifumi Sonobe, Shijie Jin, Yue Wang, Hiroshi Horiuchi, Bijay Parajuli, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumura

Journal of neuroimmunology 269(1-2) 38-43 2014年4月15日査読有り
Granulocyte-colony stimulating factor attenuates oligomeric amyloid β neurotoxicity by activation of neprilysin.

Yukiko Doi, Hideyuki Takeuchi, Hiroyuki Mizoguchi, Kazuya Fukumoto, Hiroshi Horiuchi, Shijie Jin, Jun Kawanokuchi, Bijay Parajuli, Yoshifumi Sonobe, Tetsuya Mizuno …

PLoS One 9(7) e103458 2014年査読有り
Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes.

Yue Wang, Shijie Jin, Yoshifumi Sonobe, Yi Cheng, Hiroshi Horiuchi, Bijay Parajuli, Jun Kawanokuchi, Tetsuya Mizuno, Hideyuki Takeuchi, Akio Suzumura

PLoS One 9(10) e110024 2014年査読有り
Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells.

Shijie Jin, Yoshifumi Sonobe, Jun Kawanokuchi, Hiroshi Horiuchi, Yi Cheng, Yue Wang, Tetsuya Mizuno, Hideyuki Takeuchi, Akio Suzumura

PLoS One 9(12) e115981 2014年査読有り
Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer's disease.

B Parajuli, Y Sonobe, H Horiuchi, H Takeuchi, T Mizuno, A Suzumura

Cell Death & Disease 4 e975 2013年12月19日査読有り
Interleukin-27 promotes inflammatory and neuroprotective responses in microglia

Jun Kawanokuchi, Hideyuki Takeuchi, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumura

Clinical and Experimental Neuroimmunology 4(1) 36-45 2013年6月査読有り
The neurotoxic effect of astrocytes activated with toll-like receptor ligands.

Di Ma, Shijie Jin, Endong Li, Yukiko Doi, Bijiya Parajuli, Mariko Noda, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumura

Journal of neuroimmunology 254(1-2) 10-18 2013年1月15日査読有り
Fingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons.

Yukiko Doi, Hideyuki Takeuchi, Hiroshi Horiuchi, Taketo Hanyu, Jun Kawanokuchi, Shijie Jin, Bijay Parajuli, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumura

PLoS One 8(4) e61988 2013年査読有り
GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia.

Bijay Parajuli, Yoshifumi Sonobe, Jun Kawanokuchi, Yukiko Doi, Mariko Noda, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura

Journal of Neuroinflammation 9 268 2012年12月13日査読有り責任著者
The neuroprotective role of microglia treated with milk fat globule-EGF factor 8

Tetsuya Mizuno, Mariko Noda, Endong Li, Yukiko Doi, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Hideyuki Takeuchi, Akio Suzumura

JOURNAL OF NEUROIMMUNOLOGY 253(1-2) 152-153 2012年12月査読有り
TGF-β induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid β neurotoxicity.

Di Ma, Yukiko Doi, Shijie Jin, Endong Li, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura

Neuroscience Letters 529(1) 86-91 2012年10月31日査読有り

もっとみる

MISC

FTY720 has the effects of anti-inflammation and neuroprotection on microglia

Hiromi Noda, Jun Kawanokuchi, Yukiko Doi, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura

JOURNAL OF NEUROIMMUNOLOGY 253(1-2) 109-109 2012年12月
GM-CSF induces dendritic-cell like microglia through classical PKC/AP-1-dependent pathway

Yoshifumi Sonobe, Bijay Parajuli, Hiromitsu Tabata, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura

JOURNAL OF NEUROIMMUNOLOGY 253(1-2) 44-44 2012年12月
Midkine exacerbates experimental autoimmune encephalomyelitis through suppressing expansion of regulatory dendritic cells

Yoshifumi Sonobe, Hua Li, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura

JOURNAL OF NEUROIMMUNOLOGY 228(1-2) 110-111 2010年11月
多発性硬化症とIL-25

薗部佳史, 錫村明生

Current Insights in Neurological Sciences 18(2) 10-11 2010年
IL-25 expressed by brain capillary endothelial cells rescues blood-brain barrier dysfunction

Yoshifumi Sonobe, Hideyuki Takeuchi, Kunio Kataoka, Hua Li, Shijie Jin, Maya Mimuro, Yoshio Hashizume, Yasuteru Sano, Takashi Kanda, Tetsuya Mizuno …

NEUROSCIENCE RESEARCH 65 S150-S150 2009年
GM-CSF-stimulated microglia differentiate into dendritic-like antigen-presenting cells

Hua Li, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura

NEUROSCIENCE RESEARCH 65 S249-S249 2009年
Microglia/macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors

Yohei Harada, Izumi Yawata, Hideyuki Takeuchi, Yoshifumi Sonobe, Shijie Jin, Yukiko Doi, Jianfeng Liang, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumura

JOURNAL OF NEUROIMMUNOLOGY 203(2) 249-249 2008年10月
Interleukin-25 improves tumor necrosis factor-alpha- induced disruption of blood brain barrier properties in mouse brain capillary enclothelial cells

Yoshifumi Sonobe, Hideyuki Takeuchi, Kunio Kataoka, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumura

JOURNAL OF NEUROIMMUNOLOGY 203(2) 145-145 2008年10月
The function of interleukin-33 (IL-33) in the central nervous system

Satoko Yasuoka, Jun Kawanokuchi, Yoshifumi Sonobe, Yukiko Doi, Jianfeng Liang, Tetsuya Mizuno, Hideyuki Takeuchi, Akio Suzumura

NEUROSCIENCE RESEARCH 61 S110-S110 2008年
Comparison research on excitatory amino acid transporters between astrocyte and microglia

Jianfeng Liang, Hideyuki Takeuchi, Jun Kawanokuchi, Yoshifumi Sonobe, Yukiko Doi, Izumi Yawata, Shijie Jin, Jinyan Wang, Tetsuya Mizuno, Akio Suzumura

NEUROSCIENCE RESEARCH 58 S236-S236 2007年
Chronological changes of CD4(+) and CD8(+) T cell subsets in the periphery and CNS during the course of EAE

Yoshifumi Sonobe, Shijie Jin, Jinyan Wang, Jun Kawanokuchi, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura

NEUROSCIENCE RESEARCH 58 S106-S106 2007年
多発性硬化症の病態とIL-27

薗部佳史, 錫村明生

Current Insights in Neurological Sciences 15(2) 10-11 2007年
Expansion of CD4(+)CD25(+)Foxp3(+) regulatory T cells in midkine-deficiency mice results in partial resistance to experimental autoimmune encephalomyelitis: A novel immunomodulation by midkine

Jinyan Wang, Hideyuki Takeuchi, Shijie Jin, Jun Kawanokuchi, Reiko Kuno, Yoshifumi Sonobe, Izumi Yawata, Yukiko Doi, Jianfeng Liang, Guiqin Zhang …

JOURNAL OF NEUROIMMUNOLOGY 178 169-169 2006年9月
MSにおけるCD8陽性細胞とそのサブセットの役割

薗部佳史, 錫村明生

Current Insights in Neurological Sciences 13(2) 10-11 2005年

書籍等出版物

Microglia in Health and Disease

(担当:分担執筆)

Springer New York 2014年 (ISBN: 9781493914296)

所属学協会

日本神経科学学会

共同研究・競争的資金等の研究課題

抗ミッドカインRNAアプタマーによる実験的自己免疫性脳脊髄炎抑制機序の解明

日本学術振興会科学研究費助成事業若手研究(B) 若手研究(B) 2010年 - 2011年

薗部佳史