木村泰久 (Yasuhisa Kimura) - 論文

ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs.

Atsushi Kodan, Ryota Futamata, Yasuhisa Kimura, Noriyuki Kioka, Toru Nakatsu, Hiroaki Kato, Kazumitsu Ueda

FEBS letters 595(6) 707-716 2021年3月

ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking

Mitsuhiro Nakato, Naoko Shiranaga, Maiko Tomioka, Hitomi Watanabe, Junko Kurisu, Mineko Kengaku, Naoko Komura, Hiromune Ando, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda

Journal of Biological Chemistry 296 100166-100166 2021年

Stiffness of the extracellular matrix regulates differentiation into beige adipocytes.

Kyoko Takata, Tsuyoshi Goto, Mito Kuroda, Yasuhisa Kimura, Ichiro Harada, Kazumitsu Ueda, Teruo Kawada, Noriyuki Kioka

Biochemical and biophysical research communications 532(2) 205-210 2020年11月5日

In vivo FRET analyses reveal a role of ATP hydrolysis–associated conformational changes in human P-glycoprotein

Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Atsushi Kodan, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda

Journal of Biological Chemistry 295(15) 5002-5011 2020年4月10日査読有り

Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1

Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Matsuoka, Yasuhisa Kimura, Kazumitsu Ueda, Hiroaki Kato

Nature Communications 10(1) 88-88 2019年12月1日

Changes in the asymmetric distribution of cholesterol in the plasma membrane influence streptolysin O pore formation

Fumihiko Ogasawara, Fumi Kano, Masayuki Murata, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda

Scientific Reports 9 2019年12月1日

C-terminal of ABCA1 separately regulates cholesterol floppase activity and cholesterol efflux activity.

Okamoto Y, Tomioka M, Ogasawara F, Nagaiwa K, Kimura Y, Kioka N, Ueda K

Bioscience, biotechnology, and biochemistry 1-10 2019年12月査読有り

The role of ATP hydrolysis in conformational changes of human P-glycoprotein in living cells

Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Atsushi Kodan, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda

bioRxiv 2019年11月

How ATP is used by P-glycoprotein to export multiple hydrophobic compounds

Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda

2019年5月

An amphipathic helix of vinexin α is necessary for a substrate stiffness-dependent conformational change in vinculin

Naoya Hino, Takafumi Ichikawa, Yasuhisa Kimura, Michiyuki Matsuda, Kazumitsu Ueda, Noriyuki Kioka

Journal of Cell Science 132(2) 2019年1月1日

Apolipoprotein A-I directly interacts with extracellular domain 1 of human ABCA1

Takaaki Kawanobe, Naoko Shiranaga, Noriyuki Kioka, Yasuhisa Kimura, Kazumitsu Ueda

Bioscience, Biotechnology and Biochemistry 83 490-497 2019年1月1日

Estimation of ABCB1 concentration in plasma membrane

Petr Mlejnek, Petr Kosztyu, Petr Dolezel, Yasuhisa Kimura, Katerina Cizkova, Eliska Ruzickova

Journal of Cellular Biochemistry 120 18406-18414 2019年1月1日

Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation

Masato Ishigami, Fumihiko Ogasawara, Kohjiro Nagao, Hidehiko Hashimoto, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda

Scientific Reports 8(1) 2018年12月1日

Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols

Ana Perea, José Ignacio Manzano, Yasuhisa Kimura, Kazumitsu Ueda, Santiago Castanys, Francisco Gamarro

Biochemical Journal 475(1) 87-97 2018年1月15日

Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation

Takafumi Ichikawa, Masahiro Kita, Tsubasa S. Matsui, Ayaka Ichikawa Nagasato, Tomohiko Araki, Shian-Huey Chiang, Takuhito Sezaki, Yasuhisa Kimura, Kazumitsu Ueda, Shinji Deguchi, Alan R. Saltiel, Noriyuki Kioka

JOURNAL OF CELL SCIENCE 130(20) 3517-3531 2017年10月

Vinculin association with actin cytoskeleton is necessary for stiffness-dependent regulation of vinculin behaviore

Tomohiro Omachi, Takafumi Ichikawa, Yasuhisa Kimura, Kazumitsu Ueda, Noriyuki Kioka

PLOS ONE 12(4) 2017年4月

Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes

Mito Kuroda, Hiroki Wada, Yasuhisa Kimura, Kazumitsu Ueda, Noriyuki Kioka

JOURNAL OF CELL SCIENCE 130(5) 989-1002 2017年3月

Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport

Ken-ichi Miyata, Yoshiaki Nakagawa, Yasuhisa Kimura, Kazumitsu Ueda, Miki Akamatsu

BIOORGANIC & MEDICINAL CHEMISTRY 24(14) 3184-3191 2016年7月

In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines

Ken-ichi Miyata, Yoshiaki Nakagawa, Yasuhisa Kimura, Kazumitsu Ueda, Miki Akamatsu

TOXICOLOGY AND APPLIED PHARMACOLOGY 298 40-47 2016年5月

Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1

Shimpei Itoh, Kohjiro Nagao, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 79(5) 775-781 2015年5月

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