論文

査読有り 国際誌
2018年11月30日

Longitudinal changes in the mismatch field evoked by an empathic voice reflect changes in the empathy quotient in autism spectrum disorder.

Psychiatry research. Neuroimaging
  • Yuko Yoshimura
  • ,
  • Mitsuru Kikuchi
  • ,
  • Hirotoshi Hiraishi
  • ,
  • Chiaki Hasegawa
  • ,
  • Tetsu Hirosawa
  • ,
  • Tetsuya Takahashi
  • ,
  • Toshio Munesue
  • ,
  • Hirotaka Kosaka
  • ,
  • Haruhiro Hiagashida
  • ,
  • Yoshio Minabe

281
281
開始ページ
117
終了ページ
122
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.pscychresns.2018.05.003

Autism spectrum disorders (ASDs) are neurodevelopmental conditions with impairments in social communication and interaction. Empathy is the ability to understand and share another person's inner life, and it is an essential process in social cognition, which is deficient in ASD. The mismatch field (MMF) has been used as a neurophysiological marker for the automatic detection of changes in auditory stimuli. In the present study, we focused on long-term changes in MMF evoked by an empathic voice and changes in the empathy quotient (EQ) in ASD during an 8-week clinical trial using oxytocin (OT). Ten males with ASD without intellectual disability participated in this pilot study. The results demonstrated a significant positive correlation between the change in the MMF amplitude in the auditory cortex (i.e., right banks of the superior sulcus) and the change in the EQ score during the 8-week clinical trial, whereas no significant change was observed in the MMF amplitude or EQ score after the administration period of OT. Although we cannot conclude that the observed relationships were caused by OT's effect or by natural changes, our results suggest that MMF evoked by social voice can be a state-dependent marker of empathic abilities in male adults with ASD.

リンク情報
DOI
https://doi.org/10.1016/j.pscychresns.2018.05.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30292077
ID情報
  • DOI : 10.1016/j.pscychresns.2018.05.003
  • ISSN : 0925-4927
  • PubMed ID : 30292077

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